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FYN


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Gene DB Home
Symbol:FYN
Name(s):FYN oncogene related to SRC, FGR, YES
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC45350, SLK, SYN
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18056706 engagement of the SH2 domain on PAG renders FynT insensitive to Csk negative regulation
17701175 Fyn is weakly phosphorylated in normal B cells, but strongly phosphorylated in myeloma B cells.
18267011 NS5A binds to the Fyn SH3 domain with what can be considered a high affinity SH3 domain-ligand interaction (629 nM), and this binding did not require the presence of domain I of NS5A (amino acid residues 32-250).
11121167 Observational study of gene-disease association. (HuGE Navigator)
14675807 Observational study of gene-disease association. (HuGE Navigator)
15082191 Observational study of gene-disease association. (HuGE Navigator)
15098360 Observational study of gene-disease association. (HuGE Navigator)
17334644 Observational study of gene-disease association. (HuGE Navigator)
17417065 Observational study of gene-disease association. (HuGE Navigator)
17703099 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAdducin 2protein-tyrosine kinase fyn isoform a--Pubmed
HPRDadducin 2 isoform aFyn--Pubmed
HPRDFas receptorprotein-tyrosine kinase fyn isoform a--Pubmed
HPRDtumor necrosis factor receptor superfamily, member 6 isoform 1 precursorFyn--Pubmed
HPRDFAS ligandprotein-tyrosine kinase fyn isoform a--Pubmed
HPRDfas ligandFyn--Pubmed
HPRDB-cell CLL/lymphoma 3protein-tyrosine kinase fyn isoform a--Pubmed
HPRDB-cell CLL/lymphoma 3protein-tyrosine kinase fyn isoform a--Pubmed
HPRDCas-Br-M ecotropic retroviral transforming sequenceprotein-tyrosine kinase fyn isoform a--Pubmed
HPRDHuman T-cell surface antigen CD2 mRNA, and translated productsprotein-tyrosine kinase fyn isoform a--Pubmed

Recent Publications on FYN:

Pubmed Logo
Phosphorylation of Nephrin Triggers Its Internalization by Raft-Mediated Endocytosis.
Proper localization of nephrin determines integrity of the glomerular slit...
24th October, 2009
*Department of Clinical Biology and Medicine, University of Tokushima J Am Soc Nephrol. 2009 Oct 22.
DOI Direct Link
alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy.
Adducins are cytoskeletal actin-binding proteins (alpha, beta, gamma) that...
20th October, 2009
Prassis sigma-tau Research Institute, Settimo Milanese, Milan, Italy. J Mol Med. 2009 Oct 17.
DOI Direct Link
Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.
Multiple Src family kinases (SFKs) are present in murine embryonic stem...
15th October, 2009
University of Pittsburgh School of Medicine, Department of Microbiology Sci Signal. 2009 Oct 13;2(92):ra64.
DOI Direct Link
Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.
The receptor-type protein tyrosine phosphatases (RPTPs) have been linked...
10th October, 2009
[1] Brain Research Center, Korea Research Institute of Bioscience and EMBO J. 2009 Oct 8.
DOI Direct Link
Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development.
Mutations in LAMA2, the gene for the extracellular matrix protein...
10th October, 2009
Department of Pharmacology, Stony Brook University, New York 11794, USA. J Neurosci. 2009 Sep 23;29(38):11794-806.
DOI Direct Link

View more research publications.

BioNews Results for FYN

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Nano-size capsule that boosts the body's uptake of curcumin being developed
News-Medical.Net:  Nov 5 2009 12:20PM Matching: fyn

Clinical Trials:

Clinical Trials Logo
Nurse Tele-Consultations With Discharged COPD Patients Reduce the Numbers of Readmissions

Patents:

Patents logo
US Patent No.Title
7560568 Thiazole compounds
7582461 Kinase and phosphatase assays
7582635 Therapeutic agents useful for treating pain
7582637 Pyrrolo-pyridine kinase modulators
7582655 Antineoplastic compounds

View more patents.

FYN results (if any) from reagent suppliers

Google CSE Logo
Fyn Antibody #4023
Fyn Antibody detects endogenous levels of total Fyn proteins. This antibody does not cross-react with Src and Hck family members. ...
http://www.cellsignal.com/products/4023.html...

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Fyn Antibody / Fyn Antibodies
Fyn Antibody / Fyn Antibodies. ... Fyn specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-fyn.html...

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Fyn antibody [FYN-01] (ab1881) | Abcam
Mouse monoclonal [FYN-01] to Fyn. Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59kDa, which belongs to the Src family of
...
http://www.abcam.com/Fyn-antibody-FYN-01-ab1881.html...

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Purified Anti-Fyn Antibody - BioLegend
Purified Anti-Fyn Antibody - Fyn is a 59 kD protein tyrosine kinase and a member of the src subfamily.
http://www.biolegend.com/purified-anti-fyn-antibody-2871.htm...

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Fyn (15) Antibody sc-434
See how others have used Fyn (15): sc-434 antibody and or Fyn (15) antibody conjugates. ... Fyn (15) PE: sc-434 PE. Intracellular FCM analysis of fixed and
...
http://www.scbt.com/datasheet-434-fyn-15-antibody.html...

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Fyn (phospho Y530) antibody (ab53690) | Abcam
Rabbit polyclonal to Fyn (phospho Y530). Fyn is a membrane-associated, non- receptor protein tyrosine kinase approximately 59kDa, which belongs to the Src
...
http://www.abcam.com/Fyn-phospho-Y530-antibody-ab53690.html...

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p-Fyn (Thr 12) Antibody sc-16848
See how others have used p-Fyn (Thr 12): sc-16848 antibody and or p-Fyn ... Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn.
...
http://www.scbt.com/datasheet-16848-p-fyn-thr-12-antibody.ht...

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