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G6PC
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15316959 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 15918042 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18008183 |
analysis of mutation spectrum of glycogen storage disease type Ia in Tunisia |
| 14718531 |
Glc-6-Pase-alpha and Glc-6-Pase-beta share a similar active site structure, topology, and mechanism of action |
| 12560945 |
Five mutants lack microsomal G6P uptake activity and one retains residual activity, suggesting that in G6PT the signature motif is a functional element required for microsomal glucose-6-phosphate transport. |
| 12373566 |
homozygosity for one G6PC mutation, G188R, seems to be associated with a glycogen storage disease type I non-a phenotype and homozygosity for the 727G>T mutation may be associated with a milder phenotype but an increased risk for hepatocellular carcinoma |
| 12444104 |
The amino-terminal domain of G6PT is required for optimal glucose-6-phosphate uptake activity. |
| 16893891 |
HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine |
| 14759518 |
G6pc expression was functionally silenced by adenovirus-mediated delivery of short hairpin RNA. |
| 12093795 |
active site of G6Pase: role of HIS176 as the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis | →View more information from publications. |
Recent Publications on G6PC: |  |
G6PC mutations in two patients with glycogen storage disease type Ia in Thailand.
We describe gene targeting experiments involving a human cell line (RAN10)... | 17th October, 2009
| .Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand.
| Acta Paediatr. 2009 Oct 13.
DOI Direct Link |
Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism.
Metformin is widely used as a hypoglycemic agent for the treatment of type... | 22nd September, 2009
| Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana, Osaka
| Biochem Biophys Res Commun. 2009 Oct 16;388(2):311-6. Epub 2009 Aug 5.
DOI Direct Link |
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Fasting hyperglycemia in patients with type 2 diabetes mellitus (T2DM) is... | 26th August, 2009
| Department of Internal Medicine, Yale University School of Medicine, New
| Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12121-6. Epub 2009 Jul 8.
DOI Direct Link |
Glucose-6-phosphatase catalytic subunit gene family.
Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate... | 25th August, 2009
| Barbara Davis Center for Childhood Diabetes, University of Colorado at
| J Biol Chem. 2009 Oct 23;284(43):29241-5. Epub 2009 Aug 20.
DOI Direct Link |
Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice.
Obesity and obesity-related illnesses are global epidemics impacting the... | 12th August, 2009
| Laboratory of Pharmacology, National Institutes of Health, National
| Endocrine. 2009 Oct;36(2):311-25. Epub 2009 Aug 11.
DOI Direct Link |
→View more research publications. |
G6PC results (if any) from reagent suppliers | 
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G6Pase-α (H-60) Antibody sc-25840
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, G6PC, 2538, 17q21.31, NM_000151 ...
http://www.scbt.com/datasheet-25840-g6pase-alpha-h-60-antibo...
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C3878 Chlorogenic acid ≥95% (titration)
assay, ≥95% (titration). mp, 210 °C (dec.)(lit.) Gene Information, rat ... G6pc (25634). Safety. Personal Protective Equipment, Eyeshields, Gloves, ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C387...
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G6Pase-α (C-14) Antibody sc-27198
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, G6PC, 2538, 17q21
.31 ...
http://www.scbt.com/it/datasheet-27198-g6pase-alpha-c-14-ant...
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G6Pase-α (C-14) Antibody sc-27198
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, G6PC, 2538, 17q21.31, NM_000151 ...
http://www.scbt.com/ja/datasheet-27198-g6pase-alpha-c-14-ant...
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G6Pase-α (N-19) Antibody sc-27196
Humano, G6PC, 2538, 17q21.31, NM_000151 · P35575 · 232200. camundongo, G6pc, 14377, 11 D, P35576, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-27196-g6pase-alpha-n-19-ant...
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G6Pase-α siRNA (m) sc-145294
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, G6pc, 14377, 11 D, P35576 ...
http://www.scbt.com/ko/datasheet-145294-g6pase-alpha-sirna-m...
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