Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12750264 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15958648 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17389609 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17768380 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17952468 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17971348 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18000863 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18208821 |
Autoantibodies against Ku are elicited by macromolecular protein complexes containing Ku and the associated DNA damage proteins may be involved of autoimmunity in rheumatic diseases. |
| 17982634 |
Expression of Ku70 in breast cancer tissue and normal breast tissue with immunohistochemistry are largely equal. |
| 17885668 |
These results indicate that Bax and Ku70 acetylation play important roles in Q79C-induced cell death, and that BIP may be useful in the development of therapeutics for polyQ diseases. |
| 17617666 |
TrkA signaling appears to be proapoptotic in the absence of Ku70. |
| 17714764 |
Genes encoding KU70, MGST1 and BIK show age-related mRNA expression levels in hematopoietic stem cells. |
| 17671430 |
potential relevance of Bin1-Ku interaction to cancer are discussed in light of these findings |
| 17768380 |
The Ku70 promoter T-991C, but not the Ku70 promoter C-57G polymorphism, is correlated with pterygium. |
| 15075319 |
activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP. |
| 14991539 |
Expression of both genes was down-regulated as melanoma progressed. In situ hybridization demonstrated more Ku70- and Ku80-positive cells than immunohistochemical methods, but the correlation between the two methods was highly significant (P <0.01). |
| 16857680 |
Ku-mediated assembly of DNA-PK on DNA ends is responsible for a dissociation of the DNA-PKcs.Artemis complex. |
| 16440001 |
Ku70 has other antiapoptotic functions in Granzyme A (GzmA)-induced cell death, which are blocked when GzmA proteolyses Ku70 |
| 12324457 |
role of expression in NF-kappaB activation and COX-2 expression |
| 11821378 |
binding with inositol hexakisphosphate |
| 15123719 |
Results show that Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) modulate RAG-mediated cleavage during V(D)J recombination. |
| 16360032 |
Ku70 is a receptor for the rickettsial protein rOmpB. Bacterial internalization is dependent on the presence of cholesterol-enriched microdomains containing Ku70. |
| 12145306 |
regulates osteocalcin gene expression |
| 16713581 |
Dimeric particles are observed in which two DNA-PKcs/Ku70/Ku80 holoenzymes interact through the N-terminal HEAT repeats. |
| 17479409 |
Ku70 protein plays an important role in repair of DNA DSB (double-strand breaks) damage and for maintainance of genome stability. |
| 15019772 |
cell-surface Ku functions as an adhesion receptor for fibronectin; both Ku70 and Ku80 present a structural relationship with integrin I (or A) domains and the A1 and A3 domains of von Willebrand factor, domains known to be involved in Fn binding |
| 12518983 |
The mechanism that regulates for nuclear localization of Ku70 and Ku80 appears to play, at least in part, a key role in regulating the physiological function of Ku in vivo. |
| 17187679 |
poly(ADP-ribose)polymerase-1 and Ku70/Ku80 are transcriptional regulators of S100A9 gene expression |
| 17496833 |
These data support a new role for Ku in the migration of monocytes into tissues, which depends on a tightly regulated pathway of intracellular redistribution. |
| 12547193 |
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment |
| 15827325 |
Ku70 has a role in human cancer cell sensitization to radiation and etoposide treatments |
| 11796732 |
Studies on the mode of Ku interaction with DNA |
| 15613478 |
Histone gamma-H2AX promotes binding of nuclear DNA helicase II to transcriptionally stalled sites on chromosomal DNA. |
| 12177300 |
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus |
| 15905197 |
The level of Ku70 in the cytoplasm was decreased, but that of Bax in mitochondria was increased by justicidin A in colorectal cancer cells. |
| 16448389 |
The present study suggests that Ku binds IRES -(internal ribosomal entry site)elements within RNA molecules, and that Ku plays a role in the modulation of IRES- mediated mRNA translation. |
| 12867423 |
DNA repair proteins Ku70 and Ku80 expression is lost in cell nucleus after oxidative stress |
| 15220460 |
DNA-binding component of human OF-1 (which binds Herpes simplex virus type 1 origin of replication) contains Ku70 and Ku80 proteins |
| 17124166 |
Functions in nonhomologous DNA end joining. |
| 17202845 |
maintenance of higher expression of Ku70 and Mre11 may be responsible for keeping longer life span observed in the longevity group |
| 12664628 |
This antigen acts as the transcription factor induced by interleukins (IL)-13 and -4 leading to induction of 15-lipoxygenase (15-LO) in human cells. |
| 12664629 |
This autoantigen is induced by a divergence in intracellular signaling between IL-4 and IL-13. |
| 14734561 |
(ADP-ribosyl)ation of Ku70/80 reduces the ability of this factor to stimulate WRN exonuclease, suggesting that covalent modification of Ku70/80 by PARP-1 may play a role in the regulation of the exonucleolytic activity of WRN. |
| 14627815 |
DNA-PK can be activated by nucleosomes through the ability of Ku to bind to the ends of nucleosomal DNA, and that the activated DNA-PK is capable of phosphorylating H2AX within the nucleosomes |
| 12467650 |
Transcripts of Ku70 and Ku86 genes were detected by RT-PCR and Ku protein was localized in the nucleus of neutrophils as a heterodimer |
| 15824061 |
Ku70/80 interacts directly with the RNA component of human telomerase, independent of the human telomerase reverse transcriptase protein. |
| 14570916 |
Ku antigen interacts with RBP-Jkappa and NF-kappaB p50 may act as a positive regulator of p50 expression in gastric cancer AGS cells. |
| 17159921 |
The three-dimensional structure of the human full-length Ku70-Ku80 dimer at 25 A resolution, alone and in complex with DNA, by using single-particle electron microscopy was reconstructed. |
| 17334224 |
SIRT1 modulates DNA repair activity, which could be regulated by the acetylation status of repair protein Ku70 following DNA damage |
| 12377759 |
Ku associates with hTERT, and this interaction may function to regulate the access of telomerase to telomeric DNA ends |
| 12494870 |
In naevus cell naevi, significant correlations were found between Ku70/80 gene expression and some ploidy-related parameters. |
