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GAB1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17211494 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 18003605 |
These results suggest that coupling of Grb2 to Gab1 mediates the hepatocyte growth factor-induced strong activation of the ERK pathway, which is required for the inhibition of HepG2 cell proliferation. |
| 17625596 |
HGF signaling process from Gab1 to PI3K is negatively regulated by PKC-betaII, and its loss is critical for melanoma cells to gain invasive potential. |
| 15379552 |
extracellular signal-regulated kinases 1/2 modulate insulin action via Gab1 by targeting serine and threonine residues beside YXXM motifs |
| 12766170 |
Gab1 and the Met receptor interact in a novel manner, such that the activated kinase domain of Met and the negative charge of phosphotyrosine 1349 engage the Gab1 MBD as an extended peptide ligand |
| 17145761 |
Bisindolylmaleimide I abolishes the FGF2-mediated association of Shp2 tyrosine phosphatase with Frs2 and Gab1. |
| 15940252 |
RAI associates with the Grb 2-associated binder 1 (GAB 1) adapter. This association is constitutive, but, in the presence of RET oncoproteins, both RAI and GAB 1 are tyrosine-phosphorylated, and the stoichiometry of this interaction remarkably increases |
| 12808090 |
Gab1 is an integrator of cell death versus cell survival signals in oxidative stress |
| 16687399 |
By amplifying positive interactions between survival and mitogenic pathways, GAB1 plays the critical role in cell proliferation and tumorigenesis. |
| 11896055 |
ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase | →View more information from publications. |
Recent Publications on GAB1: |  |
Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions.
The docking protein Grb2-associated binder1 (Gab1) has a central role in... | 3rd November, 2009
| Department of Life Science, National Chung Hsing University, Taichung,
| Oncogene. 2009 Nov 2.
DOI Direct Link |
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Interleukin-6 (IL-6) is a key mediator of inflammation. Inhibitors of IL-6... | 30th October, 2009
| Department of Physiology and Medical Physics, Division of Physiology,
| J Neurosci. 2009 Oct 28;29(43):13473-83.
DOI Direct Link |
RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling.
Aberrant activity of the phosphatidylinositol 3-kinase (PI3K) pathway... | 29th September, 2009
| Molecular Signal Transduction Section, Laboratory of Allergic Diseases,
| J Biol Chem. 2009 Aug 7;284(32):21719-27. Epub 2009 Jun 9.
DOI Direct Link |
GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.
Adaptor proteins for the various growth factor receptors play a crucial... | 29th September, 2009
| Division of Disease Proteomics, Institute for Enzyme Research, the
| J Biol Chem. 2009 Jul 24;284(30):20206-14. Epub 2009 Jun 9.
DOI Direct Link |
Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway.
The precise mechanism whereby epidermal growth factor (EGF) activates the... | 26th September, 2009
| Department of Molecular Microbiology and Immunology, Brown University,
| Sci Signal. 2009 Apr 28;2(68):ra17.
DOI Direct Link |
→View more research publications. |
GAB1 results (if any) from reagent suppliers | 
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