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GABRR1


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Symbol:GABRR1
Name(s):gamma-aminobutyric acid (GABA) receptor, rho 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC163216
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18227272 Results imply that the M3M4 loop is not essential for GABA rho1 receptor assembly and function and suggest that the cytoplasmic domain may fold as an independent module from the transmembrane and extracellular domains.
18079559 Charge selectivity of the anionic rho1 GABA receptor can be influenced by the introduction of glutamates, one at a time, over an 8-amino acid stretch (-2' to 5') in the proposed intracellular end of TM2 and the TM1-TM2 intracellular linker.
15548535 a complete model of the GABA(C) receptor binding pocket was proposed and discussed in comparison with the GABA(A) receptor binding pocket
12226075 Tyr-102 is a component of the GABA binding domain and it might be important for coupling agonist binding to channel opening
15163459 a single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism
16198491 GABA receptor subunit rho-1 effectively altered gene expression through its interaction with the cellular retinoic acid binding protein pathway
11862606 examination of receptor modulation by divalent cations

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDGamma aminobutyric acid receptor, rho 1microtubule-associated protein 1B isoform 1--Pubmed
HPRDGamma aminobutyric acid receptor, rho 1purinergic receptor P2X2 isoform D--Pubmed
HPRDgamma-aminobutyric acid receptor, rho 1Microtubule associated protein 1B--Pubmed
HPRDgamma-aminobutyric acid receptor, rho 1Solute carrier family 6 member 9--Pubmed
HPRDgamma-aminobutyric acid receptor, rho 1Solute carrier family 39, member 3--Pubmed
HPRDgamma-aminobutyric acid receptor, rho 1Purinergic receptor P2X ligand gated ion channel 2--Pubmed
HPRDgamma-aminobutyric acid receptor, rho 1gamma-aminobutyric acid receptor, rho 2 precursor--Pubmed
HPRDgamma-aminobutyric acid receptor, rho 1gamma-aminobutyric acid receptor, rho 2 precursor--Pubmed

Recent Publications on GABRR1:

Pubmed Logo
GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.
The genes encoding several GABA-A receptor subunits, including GABRA2,...
19th June, 2009
Department of Biochemistry and Molecular Biology, Indiana University Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 17.
DOI Direct Link
Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype.
Despite compelling evidence for a major genetic contribution to risk of...
17th December, 2008
1Department of Psychological Medicine, School of Medicine, Cardiff Mol Psychiatry. 2008 Jul 1.
DOI Direct Link
Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors.
GABA receptor (GABAR) types C (GABACR) and A (GABAAR) are both GABA-gated...
28th October, 2008
Division of Neurobiology, Barrow Neurological Institute, 350 West Thomas Mol Pharmacol. 2008 Oct;74(4):941-51. Epub 2008 Jul 3.
DOI Direct Link
GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220.
In our previous study, anti-apoptotic effects of GABA(C)-receptor...
25th July, 2008
Department of Pharmacology, Kansai Medical University, Moriguchi, Osaka, J Pharmacol Sci. 2008 Apr;106(4):578-84. Epub 2008 Apr 3.
Expression of GABArho subunits during rat cerebellum development.
In the present study, we provide evidence for the expression of all three...
25th April, 2008
Instituto de Neurobiologia, Departamento de Neurobiologia Molecular y Neurosci Lett. 2008 Feb 13;432(1):1-6. Epub 2007 Dec 14.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6586582 Human GABA receptor proteins and polynucleotides encoding the same

GABRR1 results (if any) from reagent suppliers

Google CSE Logo
GABAA Rρ1 (V-17) Antibody sc-22960
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GABRR1, 2569, 6q15, NM_002042 ...
http://www.scbt.com/datasheet-22960-gabaa-rrho1-v-17-antibod...

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Anti-GABAA Receptor (γ2 subunit), Cytosolic Loop Developed in ...
2 (GABRR2) and rho-1 (GABRR1) to human and mouse chromosome 4. Genomics, 12, 801 -806. (1992). 4. Jones, A., et al., Ligand-gated ion channel subunit ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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GABA Receptor Antibody / GABA Receptor Antibodies
GABA Receptor Antibody / GABA Receptor Antibodies.
http://www.scbt.com/table-gaba_receptor.html...

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GABAA Rρ1 (H-70) Antibody sc-25707
Humano, GABRR1, 2569, 6q15, NM_002042 · P24046 · 137161. camundongo, Gabrr1, 14408, 4 A5, P56475, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-25707-gabaa-rrho1-h-70-anti...

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GABAA Rρ1 (N-19) Antibody sc-21336
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, GABRR1, 2569,
6q15 ...
http://www.scbt.com/it/datasheet-21336-gabaa-rrho1-n-19-anti...

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GABAA Rρ1 (H-70) Antibody sc-25707
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, GABRR1, 2569, 6q15, NM_002042 · P24046
...
http://www.scbt.com/ja/datasheet-25707-gabaa-rrho1-h-70-anti...

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