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BACE2
| Symbol: | BACE2 | | Name(s): | beta-site APP-cleaving enzyme 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12707937 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16023140 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17113083 |
These results indicate that increased V(max) for beta-secretase is a feature of AD pathogenesis and this increase does not correlate directly with levels of BACE1, the principal beta-secretase in brain. |
| 12611455 |
A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer. ALP56 may be a useful target molecule in breast cancer treatment. |
| 16816112 |
BACE2is not involved in the Alzheimer dissease(AD)pathogenesis of Down syndrome (DS) patients; instead, therapeutic interventions that potentiate BACE2 may prevent AD pathogenesis. |
| 12618121 |
BACE1 and BACE2 (a) are expressed in normal adult muscle at the postsynaptic domain of neuromuscular junctions, and in cultured human muscle; (b) accumulate in the form of plaque-like inclusions in myositis vacuolated and necrotic muscle fibers |
| 12093293 |
Specificity and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity |
| 16757812 |
Data characterize the human beta-secretase 2 (BACE2) 5'-flanking region. |
| 17307738 |
BACE1 and BACE2 may act as alternative alpha-secretase-like proteases in proteolytic processing of IL-1R2 and APP |
| 11741910 |
BACE has a loose substrate specificity and that the substrate recognition site in BACE extends over several amino acids | →View more information from publications. |
Recent Publications on BACE2: |  |
Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.
BACE2 is homologous to BACE1, a beta-secretase that is involved in the... | 21st October, 2009
| Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona
| Genes Brain Behav. 2009 Sep 22.
DOI Direct Link |
Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors.
The identification of small molecule aminoimidazoles as potent and... | 18th September, 2009
| Department of Chemical Sciences, Wyeth Research, CN 8000, Princeton, New
| J Med Chem. 2009 Oct 22;52(20):6314-23.
DOI Direct Link |
Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli.
Evidence for a key role of beta-amyloid (Abeta) in Alzheimer's disease has... | 11th August, 2009
| Global Research and Development, St. Louis Laboratories, Pfizer Inc., 700
| Protein Pept Lett. 2009;16(2):121-31.
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Regulation of secretases by all-trans-retinoic acid.
One of the emerging approaches for the treatment of Alzheimer's disease... | 31st July, 2009
| Institute of Pharmaceutical Biology, University of Basel, Switzerland.
| FEBS J. 2009 May;276(9):2645-55. Epub 2009 Mar 25.
DOI Direct Link |
Lack of association between the polymorphisms of beta-site APP-cleaving enzyme 2 (BACE2) 5'-flanking region and sporadic Alzheimer's disease.
Amyloid beta-peptide (A beta) plays a central role in the pathogenesis of... | 2nd April, 2009
| Department of Neurology, Xuan Wu Hospital of the Capital Medical
| Brain Res. 2009 Feb 27;1257:10-5. Epub 2008 Dec 24.
DOI Direct Link |
→View more research publications. |
BACE2 results (if any) from reagent suppliers | 
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