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AMBP


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Symbol:AMBP
Name(s):alpha-1-microglobulin/bikunin precursor
Type:protein-coding
Organism:Homo sapiens
Synonyms:HCP, ITI, ITIL, UTI
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18046670 in multiple myeloma patients without renal failure, elevated Alpha-1-microglobulin excretion might be an early marker of renal tubular involvement
17766242 AMBP has radical scavenging activity.
17146627 Bikunin was found to localize on the cell membrane, while tryptase was in the secretary granules of the mast cells from psoriatic lesions.
17115277 Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma.
17584166 small angle X-ray scanning study of the monomer and dimer forms of alpha1-microglobulin; monomer is characterised by a radius of gyration R(G)= 2.20 nm and D(max)=6.3 nm and the dimer by R(G)=2.99 nm and D(max)=9.5 nm
16140784 the second processed protein from AMBP, bikunin, strongly interacted with the full-length hepatitis E virus ORF3 protein
11877257 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.
17087727 Identification of the protein bikunin as an endogenous, competitive inhibitor of a dynorphin-converting enzyme in human cerebrospinal fluid.
15452109 alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores
15037615 Data show that alpha(1) -microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-2-macroglobulin precursoralpha-1-microglobulin/bikunin precursor--Pubmed
HPRDalbumin precursoralpha-1-microglobulin/bikunin precursor--Pubmed
HPRDalpha-1-microglobulin/bikunin precursorfibronectin 1 isoform 3 preproprotein--Pubmed

Recent Publications on AMBP:

Pubmed Logo
The treatment of hypertension with telmisartan in the sphere of circadian rhythm in metabolic syndrome in the elderly.
This study compares the efficacy of telmisartan with that of valsartan and...
27th October, 2009
Dipartimento di Scienze dell'Invecchiamento, Sapienza Universita di Roma, Arch Gerontol Geriatr. 2009;49 Suppl 1:95-101.
DOI Direct Link
Circulating hormone adrenomedullin and its binding protein protect neural cells from hypoxia-induced apoptosis.
BACKGROUND: Brain ischemia is the underlying cause of neuron death during...
16th July, 2009
The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA. Biochim Biophys Acta. 2009 May;1790(5):361-7. Epub 2009 Mar 21.
DOI Direct Link
Night/day ratio as predictor of preeclampsia in normoalbuminuric, diabetic women: early signs of blood pressure disorders.
PURPOSE: Day/night ratio from diurnal ambulatory blood pressure (AMBP) in...
16th July, 2009
Department of Obstetrics/Gynecology, Herning Hospital, Aarhus University Arch Gynecol Obstet. 2009 Jun;279(6):829-34. Epub 2008 Nov 19.
DOI Direct Link
Cardiac output and associated left ventricular hypertrophy in pediatric chronic kidney disease.
A significant number of children with chronic kidney disease (CKD) have...
19th June, 2009
Division of Nephrology and Hypertension, Cincinnati Children's Medical Pediatr Nephrol. 2009 Mar;24(3):565-70. Epub 2008 Dec 2.
DOI Direct Link
Biomarker discovery in subclinical mycobacterial infections of cattle.
BACKGROUND: Bovine tuberculosis is a highly prevalent infectious disease...
18th June, 2009
Department of Veterinary Population Medicine, University of Minnesota, St PLoS One. 2009;4(5):e5478. Epub 2009 May 8.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR)

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
6989369 Kunitz domain peptides
6908740 Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
6884781 Treatment of shock using adrenomedullin binding protein-1
6864237 Treatment of shock using adrenomedullin and adrenomedullin binding protein-1

View more patents.

AMBP results (if any) from reagent suppliers

Google CSE Logo
AMBP (α-1-microglobulin/bikunin precursor) Antibody / AMBP (α-1 ...
AMBP (α-1-microglobulin/bikunin precursor) Antibody / AMBP (α-1-microglobulin/ bikunin precursor) Antibodies.
http://www.scbt.com/table-ambp_alpha_1_microglobulin_bikunin...

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Ambp native protein, UTI Human native protein
Buy quality Ambp native protein (hu urine.), Ambp, UTI Human native protein, (n/ an/a). Urinary Trypsin Inhibitor-Ulinastatin Human; N/A; Protein AMBP, ...
http://www.genwaybio.com/product_info.php?products_id=46067...

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AMBP (532) Antibody sc-81948
Additional AMBP (α-1-microglobulin/bikunin precursor) Antibodies . ... Western blot analysis of AMBP expression in A-549 whole cell lysate. ...
http://www.scbt.com/datasheet-81948-AMBP-532-antibody.html...

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Abgent - Cell and Function Antibodies
AT1129a, AMBP monoclonal antibody (M01), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H. AT1130a, AMBP monoclonal antibody (M12), ELISA,WB, H ...
http://www.abgent.com/products/category/cell_function...

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AMBP siRNA (m) sc-39553
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: AMBP (m)-PR: sc-39553-PR, 20 µl ...
http://www.scbt.com/datasheet-39553-ambp-sirna-m.html...

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Evaluation of Methods for Removal of Highly Abundant Human Plasma ...
Alpha-1-microglobulin (AMBP protein). * inter-alpha (globulin) inhibitor H4. *. Plasminogen precursor. *. Examples of "SuperMix" depletion results ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General_...

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AMBP (α-1-microglobulin/bikunin precursor) Antibody / AMBP (α-1 ...
AMBP (532) Antibody, sc-81948, mouse IgG1, FL (h), WB, IP, IF, ELISA, human ... AMBP (α-1-microglobulin/bikunin precursor) specific siRNA, sHRNA Plasmid과 ...
http://www.scbt.com/ko/table-ambp_alpha_1_microglobulin_biku...

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