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L3MBTL
| Symbol: | L3MBTL | | Name(s): | l(3)mbt-like (Drosophila) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DKFZp586P1522, FLJ41181, H-L(3)MBT, KIAA0681, L3MBTL1, dJ138B7.3 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18042461 |
The structural and binding studies of the two modules provide insights into the molecular principles governing the decoding of lysine methylation states, thereby highlighting a methylation state-specific layer of histone mark readout. |
| 18026117 |
An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1 |
| 15334543 |
L3MBTL may have a role in myeloid leukemia |
| 15123827 |
represents a previously undescribed imprinted locus, a vertebrate Polycomb group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions |
| 12588862 |
The ability of TEL to repress TEL-responsive promoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL interacting domains, which are mapped to their respective SPM/SAM domains. |
| 17540172 |
The MBT domain is related to protein domains that directly bind methylated histone residues and study found that L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26. |
Recent Publications on L3MBTL: |  |
Putative imprinted gene expression in uniparental bovine embryo models.
Altered patterns of gene expression and the imprinted status of genes have... | 1st October, 2008
| Monash Institute of Medical Research, Monash University, Clayton, Vic.
| Reprod Fertil Dev. 2008;20(5):589-97.
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Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1.
Lethal 3 malignant brain tumor 1 (L3MBTL1), a homolog of the Drosophila... | 31st July, 2008
| Laboratory of Molecular Aspects of Hematopoiesis, Sloan-Kettering
| Oncogene. 2008 Jul 17;27(31):4293-304. Epub 2008 Apr 14.
DOI Direct Link |
PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation.
Posttranslational modifications of the DNA-associated histone proteins... | 17th July, 2008
| Department of Biochemistry and Molecular Biology, University of Southern
| Mol Cell Biol. 2008 Jul;28(14):4459-68. Epub 2008 May 12.
DOI Direct Link |
Beyond histone methyl-lysine binding: how malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure.
Alterations in gene expression are commonly accompanied by changes in... | 25th April, 2008
| Howard Hughes Medical Institute, Department of Biochemistry, NYU-Medical
| Cell Cycle. 2008 Mar 1;7(5):578-85. Epub 2008 Jan 3.
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Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.
Human L3MBTL1, which contains three malignant brain tumor (MBT) repeats,... | 24th January, 2008
| Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New
| Mol Cell. 2007 Nov 30;28(4):677-91.
DOI Direct Link |
→View more research publications. |
L3MBTL results (if any) from reagent suppliers | 
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