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GATA2


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Gene DB Home
Symbol:GATA2
Name(s):GATA binding protein 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC2306, NFE1B
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18250304 data strongly suggest that GATA-2 mutations may play a role in acute myeloid transformation in a subset of CML patients
16934006 Observational study of gene-disease association. (HuGE Navigator)
17654061 GATA-2 expression in bone marrow stromal cells from chronic aplastic anemia was significantly lower than controls. Expression levels of GATA genes may influence hematopoiesis in BM microenvironment & relate to the pathogenesis/development of AA.
12145700 GATA-1 and GATA-2 gene expression is related to the severity of dysplasia in myelodysplastic syndrome.
12065419 role in the development and differentiation of hematopoietic progenitors; conditional activation of a GATA-2/ER chimera produced opposite effects to those observed with conditional GATA-2 expression
16672344 Gata2 can operate independently of neuronal differentiation
16607277 Altered histone modification of the promoter loci is one mechanism responsible for the silencing of GATA transcription factors.
12432220 REVIEW: Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage
16153155 GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (ADH1A) gene.
15254248 there is functional cross talk between RA and GATA-2-dependent pathways

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDGATA binding protein 2promyelocytic leukemia protein isoform 1--Pubmed
HPRDGATA binding protein 2PIT 1--Pubmed
HPRDGATA binding protein 2PML--Pubmed
HPRDGATA binding protein 2retinoic acid receptor, alpha isoform a--Pubmed
HPRDGATA binding protein 2retinoic acid receptor, alpha isoform a--Pubmed
HPRDGATA binding protein 2jun oncogene--Pubmed
HPRDGATA binding protein 2jun oncogene--Pubmed
HPRDGATA binding protein 2spleen focus forming virus proviral integration oncogene spi1--Pubmed
HPRDGATA binding protein 2spleen focus forming virus proviral integration oncogene spi1--Pubmed
HPRDGATA binding protein 2histone deacetylase 3--Pubmed

Recent Publications on GATA2:

Pubmed Logo
Association study of GATA-2 transcription factor gene (GATA2) polymorphism and Parkinson's disease.
It was shown that high levels of alpha-synuclein in substantia nigra are...
30th October, 2009
Department of Experimental and Clinical Pharmacology, Pomeranian Medical Parkinsonism Relat Disord. 2009 Oct 26.
DOI Direct Link
Genetic evidence for a role of IL33 in nasal polyposis.
Background: Little is known about the genetic factors that contribute to...
29th October, 2009
Vesalius Research Center (VRC), VIB, Leuven, Belgium. Allergy. 2009 Oct 26.
DOI Direct Link
GATA factors in human neuroblastoma: distinctive expression patterns in clinical subtypes.
BACKGROUND: The aim of this study is to elucidate the expression patterns...
29th October, 2009
Department of Neonatology, Charite-Universitatsmedizin Berlin, Berlin, Br J Cancer. 2009 Oct 20;101(8):1481-9. Epub 2009 Aug 25.
DOI Direct Link
The spatial repositioning of adipogenesis genes is correlated with their expression status in a porcine mesenchymal stem cell adipogenesis model system.
Alterations in the nuclear positioning of chromosomes and specific genes...
17th October, 2009
Department of Genetics and Animal Breeding, Poznan University of Life Chromosoma. 2009 Oct;118(5):647-63. Epub 2009 Jul 8.
DOI Direct Link
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
Monoaminergic neurons include the physiologically important central...
25th September, 2009
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, Development. 2009 Jul;136(14):2477-85.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6313280 SMAD-interacting polypeptides and their use
6936417 Gene expression in bladder tumors
7015037 Multiponent adult stem cells and methods for isolation
7023058 Semiconductor integrated circuit device
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

GATA2 results (if any) from reagent suppliers

Google CSE Logo
GATA2 antibody - ChIP Grade (ab22849) | Abcam
Rabbit polyclonal to GATA2 - ChIP Grade. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes,
...
http://www.abcam.com/GATA2-antibody-ChIP-Grade-ab22849.html...

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GATA-2 Antibody #4595
Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) derived from the sequence of human GATA-2. ...
http://www.cellsignal.com/products/4595.html...

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GATA-2 (H-116) Antibody sc-9008
See how others have used GATA-2 (H-116): sc-9008 antibody and or GATA-2 (H-116) ... Western blot analysis of GATA-2 expression in MCP-5 whole cell lysate. ...
http://www.scbt.com/datasheet-9008-gata-2-h-116-antibody.htm...

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GATA2 antibody (ab55079) | Abcam
Mouse monoclonal to GATA2. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, ...
http://www.abcam.com/GATA2-antibody-ab55079.html...

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GATA-2/3 (C-20) Antibody sc-1235
See how others have used GATA-2/3 (C-20): sc-1235 antibody and or ... Expression and domain-specific function of GATA-2 during differentiation of the ...
http://www.scbt.com/datasheet-1235-gata-2-3-c-20-antibody.ht...

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GATA2 monoclonal antibody (M01)
Immunofluorescence of monoclonal antibody to GATA2 (AT2157a) on HeLa cell . ... Western blot analysis of GATA2 over-expressed 293 cell line, ...
http://www.abgent.com/products/catalog_no/AT2157a_GATA2_mono...

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GATA2 antibodies: Chromatin and Nuclear Signaling > Transcription ...
GATA2 antibodies. ... GATA2 antibody - ChIP Grade. IHC-P, WB, ChIP. Images · Customer Abreviews: 4 stars (out of 5) · Specific publication references ...
http://www.abcam.com/index.html?t=116009&pt=1&c=914&ei=&mu=r...

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