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TINF2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18252230 |
TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. |
| 12835755 |
TIN2 alters the conformation of TRF1, which favours a tertiary telomeric structure that hinders telomerase from gaining access to telomeres |
| 11938440 |
Co-localises with the interstitial TTAGGG repeats in interstitial telomeres. |
| 15741234 |
a novel extra-telomeric organization of TIN2 is associated with the control of cell proliferation; TIN2 is an important regulator of mammary epithelial differentiation |
| 15292264 |
TIN2 mutants defective in binding of TRF1 or TRF2 induce a DNA damage response and destabilize TRF1 and TRF2 at telomeres in human cells. |
| 15316005 |
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres |
| 12530079 |
Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. |
| 15632001 |
May be involved in multistep hepatocarcinogenesis by playing crucial role in telomere shortening. |
| 16880378 |
coordinated interactions among TPP1, TIN2, TRF1, and TRF2 may ensure robust assembly of the telosome, telomere targeting of its subunits, and, ultimately, regulated telomere maintenance |
| 15133513 |
Partial knockdown of TIN2 by small hairpin RNA in a telomerase-positive cell line resulted in telomere elongation, which is typical of reduced TRF1 function. | →View more information from publications. |
Recent Publications on TINF2: |  |
TRFH domain is critical for TRF1-mediated telomere stabilization.
The telomeres are nucleoprotein complexes essential for maintaining the... | 9th October, 2009
| Experimental Research Center for Infectious Diseases, Institute for Virus
| Cell Struct Funct. 2009;34(2):71-6. Epub 2009 Jun 11.
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GNL3L stabilizes the TRF1 complex and promotes mitotic transition.
Telomeric repeat binding factor 1 (TRF1) is a component of the... | 14th July, 2009
| Center for Cancer and Stem Cell Biology, Alkek Institute of Biosciences
| J Cell Biol. 2009 Jun 1;185(5):827-39.
DOI Direct Link |
Dyskeratosis congenita, stem cells and telomeres.
Dyskeratosis congenita (DC) is a multi-system disorder which in its... | 8th July, 2009
| Barts and the London School of Medicine and Dentistry, Queen Mary
| Biochim Biophys Acta. 2009 Apr;1792(4):371-9. Epub 2009 Feb 7.
DOI Direct Link |
Advances in the understanding of dyskeratosis congenita.
Dyskeratosis congenita (DC) is a rare inherited syndrome exhibiting marked... | 7th July, 2009
| Centre for Paediatrics, Institute of Cell and Molecular Science, Barts and
| Br J Haematol. 2009 Apr;145(2):164-72. Epub 2009 Feb 4.
DOI Direct Link |
Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients.
Dyskeratosis congenita (DC) is an inherited multi-system disorder... | 15th May, 2009
| Centre for Paediatrics, Institute of Cell and Molecular Science, Barts and
| Br J Haematol. 2009 Mar;144(5):771-81. Epub 2008 Nov 20.
DOI Direct Link |
→View more research publications. |
TINF2 results (if any) from reagent suppliers | 
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TIN2 (L-15) Antibody sc-13645
Humain, TINF2, 26277, 14q12, NM_012461 · Q9BSI4 · 604319. Souris, Tinf2, 28113, 14 C3, Q9QXG9, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-13645-tin2-l-15-antibody.ht...
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TIN2 (L-15) Antibody sc-13645
Humano, TINF2, 26277, 14q12, NM_012461 · Q9BSI4 · 604319. Ratón, Tinf2, 28113, 14 C3, Q9QXG9, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-13645-tin2-l-15-antibody.ht...
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TIN2 (L-15) Antibody sc-13645
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, TINF2, 26277,
14q12 ...
http://www.scbt.com/it/datasheet-13645-tin2-l-15-antibody.ht...
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TIN2 (59B388) Antibody sc-52960
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TINF2, 26277, 14q12, NM_012461 ...
http://www.scbt.com/ko/datasheet-52960-tin2-59b388-antibody....
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