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GCG


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Gene DB Home
Symbol:GCG
Name(s):glucagon
Type:protein-coding
Organism:Homo sapiens
Synonyms:GLP1, GLP2, GRPP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17164779 regeneration of insulin-producing cells by GLP-1 gene therapy may be a potential method for prolonged control of type 1 diabetes in humans
17944883 Since hepatic glycogen synthesis, a GLP-1 action, was impaired, the altered expressions of GLP-1 and DPPIV may be involved in the development of HCV-associated glucose intolerance.
11961492 Observational study of gene-disease association. (HuGE Navigator)
17846745 Insulin resistance is independently associated with raised fasting plasma glucagon and proinsulin concentrations.
17901057 Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene
18180317 observations suggest that Glucagon-like peptide-1 (GLP-1) inhibits tumour necrosis factor-alpha (TNF-alpha)-mediated plasmogen activator inhibitor-1 (PAI-1)induction in vascular endothelial cells
17724330 secretion of glucagon-like peptide-1 is regualted by gustducin and sweet taste receptors.
17609256 An inverse relationship between insulin concentrations and insulin clearance suggests that the secretion of insulin itself determines the rate of hepatic insulin clearance.
17160672 Amino acid-enhanced secretion of glucagon in response to hypoglycaemia remains under physiological control since it is regulated primarily by the ambient plasma glucose concentration.
12436337 There are interactions between this protein, specific NEFA and insulin secretion

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCarboxypeptidase Eglucagon preproprotein--Pubmed
HPRDcarboxypeptidase E preproproteinGlucagon--Pubmed
HPRDGlucagonglucagon receptor--Pubmed
HPRDGlucagonglucagon-like peptide 1 receptor--Pubmed
HPRDGlucagonglucagon-like peptide 2 receptor precursor--Pubmed
HPRDglucagon preproproteinGlucagon receptor--Pubmed
HPRDglucagon preproproteinGlucagon like peptide 1 receptor--Pubmed
HPRDglucagon preproproteinGlucagon like peptide 2 receptor--Pubmed

Recent Publications on GCG:

Pubmed Logo
Specific detection of benzimidazole resistance in Colletotrichum gloeosporioides from fruit crops by PCR-RFLP.
Anthracnose diseases, caused by Colletotrichum gloeosporioides, are a...
27th October, 2009
Department of Plant Pathology, National Chung Hsing University, 250, Kuo N Biotechnol. 2009 Oct 22.
DOI Direct Link
High-level rifampin resistance correlates with multiple mutations in the rpoB gene of pulmonary tuberculosis isolates from the Afghanistan border of Iran.
The aim of this study was to investigate the significance of multiple...
27th October, 2009
Department of Pathology, The Methodist Hospital Research Institute, 6565 J Clin Microbiol. 2009 Sep;47(9):2744-50.
DOI Direct Link
Borate complexation-assisted field-enhanced sample injection for on-line preconcentration of cis-diol-containing compounds in capillary electrophoresis.
A new on-line preconcentration technique called borate...
20th October, 2009
Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Talanta. 2009 Dec 15;80(2):544-50. Epub 2009 Jul 21.
DOI Direct Link
Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia and Hyperplasia of Islet {alpha}-Cells But Not of Intestinal L-Cells.
Multiple bioactive peptides, including glucagon, glucagon-like peptide-1...
13th October, 2009
Department of Genetics, Division of Stress Adaptation and Recognition Mol Endocrinol. 2009 Oct 9.
DOI Direct Link
Cost and clinical consequence of antibiotic non-adherence in acute exacerbations of chronic bronchitis.
OBJECTIVE: To quantify the impact of non-adherence on the clinical...
2nd October, 2009
United BioSource Corporation, Bethesda, Maryland, USA. Int J Tuberc Lung Dis. 2009 Aug;13(8):945-54.

View more research publications.

Press Releases on GCG:

BioPortfolio Logo
Fort Worth Surgeon Chosen as Investigator in Clinical Trial for Weight-Loss Device 20th February, 2009 Fort Worth LAP-BAND

FORT WORTH, Texas, Feb. 20 /PRNewswire/ -- Adam B. Smith, D.O., FACOS, of Fort Worth LAP-BAND(R) is one of two surgeons in the Dallas/Fort Worth metroplex chosen by Allergan Medical for "A

BIOWISDOM APPOINTS INDUSTRY VETERAN AS DIRECTOR OF SALES AND BUSINESS 1st September, 2000 Biowisdom

BioNews Results for GCG

: RSS Logo
BioPortfolio Logo
GCG Marketing Receives Second National Healthcare Award for Childrens Cancer Awareness Campaign
Genetic Engineering News:  Nov 9 2009 1:49PM Matching: gcg
Best Corporate Advertising/Campaign
Medical Marketing And Media:  Nov 6 2009 9:59AM Matching: gcg

Clinical Trials:

Clinical Trials Logo
Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mayne Glucagon for Injection Compared With Glucagen® (Novo Nordisk) in Healthy Volunteers

Patents:

Patents logo
US Patent No.Title
7608452 Polynucleotides encoding cytokine receptor zcytor19
7608759 Scarecrow-like stress-related polypeptides and methods of use in plants
7611699 Methods of using cytokine zalpha11 ligand
7611703 Kidney disease targets and uses thereof
7611704 Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids

View more patents.

GCG results (if any) from reagent suppliers

Google CSE Logo
About Accelrys Software - Scientific Business Intelligence
... Oxford Molecular, the Genetics Computer Group (GCG®), and Synomics Ltd. In 2004, Accelrys acquired SciTegic Inc. These companies, in turn, had combined ...
http://accelrys.com/company/...

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G2654 Monoclonal Anti-Glucagon antibody produced in mouse clone ...
isotype, IgG1. Gene Information, human ... GCG(2641). rat ... Gcg(24952). mouse ... Gcg(14526). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=G265...

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Interview case study Using GCG SeqLab within a Commercial ...
how Accelrys' GCG SeqLab is used in GSK's discovery processes, by allowing easy ... aligned sequences into the GCG SeqLab editor, annotate them with text, ...
http://accelrys.com/references/case-studies/archive/studies/...

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Antibodies to Other Protein/Peptide Hormones
Gcg(14526), rat, pig, guinea pig, feline, mouse, human, canine, rabbit, DB, IHC (p), RIA, pricing. I2018, Monoclonal Anti-Insulin antibody produced in mouse ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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Development of Heterogeneous and Homogeneous Platforms for Rapid ...
3` - GCG AAC TAC TGA GTC GGC CTT 5`. 4. Fluorescein-c-Fos-1 bp mutant ... 3` GCG AAC TAC GGA GTC GCG AAC G 5`. Fluorescein-c-Fos-2 bp mutant ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General_...

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GLP-1 (F-15) Antibody sc-26637
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GCG, 2641, 2q24.2, NM_002054 ...
http://www.scbt.com/datasheet-26637-glp-1-f-15-antibody.html...

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pFLAG-CMV™-1 Expression Vector (E7273) - Datasheet
GAC TAC AAA GAC GAT GAC GAC AAG CTT GCG GCC GCG AAT TCA TCG ATA. ← Multiple Cloning Region →. ← FLAG Coding Sequence → ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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