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AATF


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Gene DB Home
Symbol:AATF
Name(s):apoptosis antagonizing transcription factor
Type:protein-coding
Organism:Homo sapiens
Synonyms:CHE-1, CHE1, DED
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17468107 Che-1 as a new Pin1 and HDM2 target and confirm its important role in the cellular response to DNA damage.
17488777 Che-1 interacts with NRAGE and NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation.
12847090 Che-1 can be considered a general HDAC1 competitor and its down-regulation is involved in colon carcinoma cell proliferation
17006618 AATF gene may be of crucial importance in maintaining the leukemic state of a cell compartment through its ability to initiate cell proliferation coupled with repression of cellular apoptosis.
14761944 apoptosis-antagonizing transcription factor binds to TSG101 in a process that enhances androgen receptor-mediated transcription by promoting its monoubiquitination
12450794 Che-1 affects cell growth by interfering with the recruitment of HDAC1 by retinoblastoma protein. Che-1 overexpression activates DNA synthesis in quiescent NIH-3T3 cells through HFDAC1 displacement.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDDeath associated protein kinase 3apoptosis antagonizing transcription factor--Pubmed
HPRDmicrotubule-associated protein tau isoform 1apoptosis antagonizing transcription factor--Pubmed
HPRDmicrotubule-associated protein tau isoform 1apoptosis antagonizing transcription factor--Pubmed
HPRDapoptosis response proteinapoptosis antagonizing transcription factor--Pubmed
BINDDNA directed RNA polymerase II polypeptide JHomo sapiens Che-1 mRNA, complete cds.Che-1 interacts with hRPB11.-Pubmed
HPRDDNA directed RNA polymerase II polypeptide Japoptosis antagonizing transcription factor--Pubmed
HPRDDNA directed RNA polymerase II polypeptide Japoptosis antagonizing transcription factor--Pubmed
BINDretinoblastoma 1Homo sapiens Che-1 mRNA, complete cds.Che-1 interacts with Rb.-Pubmed
HPRDretinoblastoma 1apoptosis antagonizing transcription factor--Pubmed
HPRDRBBP8 proteinapoptosis antagonizing transcription factor--Pubmed

Recent Publications on AATF:

Pubmed Logo
A Novel Approach to Predict Protein-Protein Interactions Related to Alzheimer's disease Based on Complex Network.
A protein domain interaction prediction program was complied using C(++)...
11th June, 2009
State key laboratory of pharmaceutical biotechnology, Nanjing University, Protein Pept Lett. 2009 Sep 10.
Novel activation domain derived from Che-1 cofactor coupled with the artificial protein Jazz drives utrophin upregulation.
Our aim is to upregulate the expression level of the dystrophin related...
5th May, 2009
Istituto di Biologia e Patologia Molecolari, CNR, c/o Regina Elena Cancer Neuromuscul Disord. 2009 Feb;19(2):158-62. Epub 2009 Jan 21.
DOI Direct Link
HIV-1 genome-encoded hiv1-mir-H1 impairs cellular responses to infection.
The recent discovery of HIV-1 genome-encoded novel microRNA (miRNA;...
17th December, 2008
Molecular Biology Unit, Department of Experimental Medicine & Mol Cell Biochem. 2009 Mar;323(1-2):143-8. Epub 2008 Dec 11.
DOI Direct Link
Delivery of agricultural technology to resource-poor farmers in Africa.
Recent developments in agricultural science and technology have the...
15th August, 2008
African Agricultural Technology Foundation, P.O. Box 30709, Nairobi, Ann N Y Acad Sci. 2008;1136:369-76. Epub 2007 Oct 22.
DOI Direct Link
ZIP kinase plays a crucial role in androgen receptor-mediated transcription.
The androgen receptor (AR) is a ligand-dependent transcription factor that...
25th June, 2008
Institute of Genetics, University of Bonn, Bonn, Germany. Oncogene. 2008 May 22;27(23):3292-300. Epub 2007 Dec 17.
DOI Direct Link

View more research publications.

BioNews Results for AATF

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BioPortfolio Logo
AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1
Cell Death and Differentiation:  Nov 13 2009 12:01PM Matching: aatf
Food Crisis Forces Changes on GM Crops
Checkbiotech:  Oct 30 2009 5:34PM Matching: aatf
Food Crisis Forces Changes on GM Crops [interview]
Individual.com:  Oct 29 2009 7:32PM Matching: aatf
Africa: Food Crisis Forces Changes on GM Crops [interview]
AllAfrica.com:  Oct 29 2009 5:35PM Matching: aatf

Patents:

Patents logo
US Patent No.Title
6966852 Modular all sports net assembly
6579196 Modular all sports net assembly

AATF results (if any) from reagent suppliers

Google CSE Logo
AATF Antibody An anti-apoptotic transcription factor
AATF antibody can be used for the detection of AATF by Western blot at 0.5 – 1 ug/ml. (Optimal dilution should be determined by user).
http://www.prosci-inc.com/shop/catalog1/AATF-Antibody-p-6151...

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AATF antibody (ab39631) | Abcam
Rabbit polyclonal to AATF. AATF (Apoptosis-antagonizing transcription factor), also termed Che-1, was identified as interacting protein of Dlk/ZIP kinase ...
http://www.abcam.com/AATF-antibody-ab39631.html...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1; Apoptosis antagonizing transcription factor; Protein AATF, IgG Polyclonal ...
http://www.genwaybio.com/all_polyclonal_antibodies.php...

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NEW PRODUCTS:
AATF antibody. 3039. H M. WB. $250/100μg. Apaf-1 (2E10) Monoclonal antibody PM2015. H. WB, IHC. $295/100μg. Apaf-1 (5E11) Monoclonal antibody PM2016 ...
http://www.prosci-inc.com/pdf/posters/newsletters/May%202006...

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CHEK1 peptide, Chk1 (Ab-280) Antibody Blocking Peptide peptide
Chk1 (Ab-280) Antibody Blocking Peptide interacts with AATF (apoptosis antagonizing transcription factor), IgG (GenWay Catalog #: 06-785-213317). ...
http://www.genwaybio.com/product_info.php?products_id=213317...

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Apoptosis Antibodies :: Page 1
AATF Antibody, 3039, H, M, E, WB, IHC, An anti-apoptotic transcription factor. Acinus Antibody, 2215, H, E, WB, ICC, (CP) Inducer of chromatin condensation ...
http://www.prosci-inc.com/shop/catalog1/Apoptosis-Antibodies...

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Abgent - Cell and Function Antibodies
AT1003a, AATF monoclonal antibody (M04), ELISA,IF,WB-Ce,WB-Re, H. AT1004a, AATF monoclonal antibody (M09), ELISA,IF,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

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