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GFRA1
| Symbol: | GFRA1 | | Name(s): | GDNF family receptor alpha 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | GDNFR, GDNFRA, GFR-ALPHA-1, MGC23045, RET1L, RETL1, TRNR1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12490080 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12624147 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16175604 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16813162 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18089803 |
GDNF can act as an important component of the inflammatory response in breast cancers and its effects aare mediated by GFR alpha 1 receptors. |
| 17825269 |
GFRalpha-1 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate. |
| 16644101 |
Loss of dopaminergic neurons in the substantia nigra may induce changes in the expression of GDNF but not its receptor snd Parkinson disease. |
| 12490080 |
GFRA1-193C > G and 537T > C could be in linkage disequilibrium with other loci responsible for medullary thyroid cancer |
| 12065680 |
The expression of GFRA1 in normal infants and normoganglionic colon of patients with Hirschsprung's disease was restricted to receptor tyrosine kinase(RET)-negative glial cells and RET-positive neurons of the ganglionic plexus. |
| 17298301 |
The role of heparin and heparan sulfate in GDNF signalling remains unclear, but the present study indicates that it does not occur in the first step of the pathway, namely GDNF-GFRalpha1 engagement. | →View more information from publications. |
Recent Publications on GFRA1: |  |
Isolation, Characterization, and Culture of Human Spermatogonia.
This study was designed to isolate, characterize, and culture human... | 23rd October, 2009
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| Biol Reprod. 2009 Oct 21.
DOI Direct Link |
Efficient enrichment of undifferentiated GFR alpha 1+ spermatogonia from immature rat testis by magnetic activated cell sorting.
Spermatogonial stem cells (SSCs) are a documented source for adult... | 3rd October, 2009
| Department of Obstetrics, Gynecology, and Reproductive Sciences,
| Cell Tissue Res. 2009 Jul;337(1):177-83. Epub 2009 May 12.
DOI Direct Link |
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells.
Stem cells give rise to differentiated cell types but also preserve their... | 24th September, 2009
| Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411-8540,
| Science. 2009 Sep 11;325(5946):1394-8.
DOI Direct Link |
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.
Inhibitory interneurons are crucially important for cerebral cortex... | 11th September, 2009
| Department of Neuroscience, Division of Molecular Neurobiology, Karolinska
| J Neurosci. 2009 Aug 26;29(34):10695-705.
DOI Direct Link |
Functional RET G691S polymorphism in cutaneous malignant melanoma.
RET proto-oncogene encodes a receptor tyrosine kinase whose ligand is... | 9th September, 2009
| Department of Molecular Oncology, John Wayne Cancer Institute at Saint
| Oncogene. 2009 Aug 27;28(34):3058-68. Epub 2009 Jun 29.
DOI Direct Link |
→View more research publications. |
GFRA1 results (if any) from reagent suppliers | 
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GFRa-1 (IN ) (GDNFRa) (GDNF receptor). Rabbit Polyclonal Antibody ...
30 Aug 2007 ... GFRa-1 (IN ) (GDNFRa) (GDNF receptor). Rabbit Polyclonal Antibody , Human,. Mouse, Rat. Legend: Western blot analysis using GFRa-1 antibody ...
http://www.exalpha.com/pdfs/X1138P.pdf...
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Antibodies to Neurotrophic Factors
Gfra1(14585) rat ... Gfra1(25454) human ... GFRA1(2674), rat, human, mouse, IHC, WB, pricing. G9415, Anti-GFRα-2 antibody produced in rabbit, (polyclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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GFRα-1 (H-70) Antibody sc-10716
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GFRA1, 2674, 10q25.3, NM_005264, ...
http://www.scbt.com/datasheet-10716-gfralpha-1-h-70-antibody...
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Goat Anti-Mouse IgG (H+L) PE conjugated secondary antibody
Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosince kinase. He Z, M-C Hofmann,
...
http://www.imgenex.com/antibody_details.php?catalog=20103...
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GFR alpha 1 Antibody (IN) GDNF receptor
Additional Names. GFR alpha 1 (IN), GFR alpha 1, GFRa-1, GDNFRa, GDNFRalpha. GFR alpha 1 Antibody. Description. Left: Western blot analysis of GFR alpha 1 ...
http://www.prosci-inc.com/shop/catalog1/GFR-alpha-1-Antibody...
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GDNF Receptor alpha 1 antibody (ab8026) | Abcam
GDNFRa was also termed Ret ligand 1 (RETL1) or TGF b related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRa 1. GFRa 1 binds GDNF specifically ...
http://www.abcam.com/gdnf-receptor-alpha-1-antibody-ab8026.h...
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Polyclonal Antibody to beta Actin
Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation ... GFRA1 (IMG-192), Figs 1B, 5D (siRNA
validated). ...
http://www.imgenex.com/antibody_details.php?catalog=IMG-5142...
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