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GGT1


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Symbol:GGT1
Name(s):gamma-glutamyltransferase 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD224, D22S672, D22S732, GGT, GTG, MGC96892, MGC96904, MGC96963
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17652002 Modest elevation of GGT observed in overweight children may be of pathophysiological importance in the long term
17698237 Association between the serum level parameters of adiposity and lipid profile.
17965490 Serum GGT may be an additional marker of arterial stiffness, especially in men, though the relationship with arterial stiffness was very weak.
17895524 The results indicate that "silent" apoptosemia occurs in T1 and T2 diabetic children and suggest elevated GGT in diabetic children could be due to release from apoptotic cells
12835487 The gamma-glutamyl transpeptidase activity in both oligoasthenospermic and azoospermic subjects were significantly lower than in asthenospermic and oligospermic individuals
15528049 Membrane GGT activity-often expressed at high levels in human malignancies-can oxidize extracellular AA and promote its uptake efficiently.
17503391 GGT1 is a biological tumor marker for epithelial ovarian cancers.
17095717 An increase in serum GGT predicts onset of metabolic syndrome, incident CVD, and death suggesting that GGT is a marker of metabolic and cardiovascular risk.
17109502 The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects.
12532447 Gamma-glutamyl transpeptidase gene expression in liver, liver disease, and liver neoplasms.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD53 antigengamma-glutamyltransferase 1--Pubmed
HPRDCD53 antigengamma-glutamyltransferase 1--Pubmed
HPRDgamma-glutamyltransferase 1large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b--Pubmed
HPRDgamma-glutamyltransferase 1large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b--Pubmed

Recent Publications on GGT1:

Pubmed Logo
Characterization of the dwg mutations: dwg and dwg ( Bayer ) are new mutant alleles of the Ggt1 gene.
The dwg and dwg ( Bayer ) are allelic mutations of the mouse that are...
18th September, 2009
Graduate School of Natural Science and Technology, Okayama University, Mamm Genome. 2009 Sep 16.
DOI Direct Link
Molecular changes to HeLa cells on continuous exposure to SN-38, an active metabolite of irinotecan hydrochloride.
It is important to clarify the molecular characteristics of tumor cells...
15th May, 2009
Department of Clinical Pharmacy, Division of Clinical Pharmaceutical Cancer Lett. 2009 Jun 8;278(1):88-96. Epub 2009 Feb 6.
DOI Direct Link
Determination of functional gamma-GTase genes and investigation of the biological activity of proteins in Arabidopsis thaliana at different stages of growth.
The results in the present study emphasize that in Arabidopsis thaliana...
27th January, 2009
Department of Botany, Faculty of Science, Tanta University, 31527 Tanta, Pak J Biol Sci. 2007 Jan 15;10(2):294-301.
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis.
The degradation pathway of glutathione (GSH) in plants is not well...
3rd January, 2009
Department of Genetics, Development, and Cell Biology, Iowa State Plant Physiol. 2008 Nov;148(3):1603-13. Epub 2008 Sep 3.
DOI Direct Link
The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells.
Staurosporine (STP) was shown to induce cell apoptosis through formation...
30th December, 2008
Department of Molecular & Cellular Physiology, Louisiana State University Biochem Pharmacol. 2009 Jan 1;77(1):76-85. Epub 2008 Sep 17.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7598080 Diagnostic assay for source of inflammation
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7291461 Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay

View more patents.

GGT1 results (if any) from reagent suppliers

Google CSE Logo
GGT1 (3E6) Antibody sc-100746
Western blot analysis of GGT1 expression in NIH/3T3 whole cell lysate. sc-100746 . GGT1 (3E6): sc-100746. Immunoperoxidase staining of formalin-fixed, ...
http://www.scbt.com/datasheet-100746-ggt1-3e6-antibody.html...

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M8439 L-Methionine Ajinomoto Amino Acid, EP, JP, USP, suitable for ...
(lit.) solubility, H2O: 50 mg/mL. suitability, suitable for cell culture. suitable for manufacturing use. Gene Information, rat ... Ggt1(116568) ...
https://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=M84...

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GGT Antibody / GGT Antibodies
GGT1/2 (A-14) Antibody, sc-23823, goat IgG, C-terminus (h) ... GGT1/2 (H-170) Antibody, sc-20639, rabbit IgG, 406-569 (h), WB, IP, IF, ELISA, m, r, h ...
http://www.scbt.com/table-ggt.html...

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G8540 L-Glutamine meets USP testing specifications, cell culture ...
(lit.) solubility, H2O: 25 mg/mL. suitability, cell culture tested. meets USP testing specifications. Gene Information, rat ... Ggt1(116568) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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GGT1 (m): 293T Lysate sc-120476
GGT1 (T-20): sc-19798. Western blot analysis of GGT1 expression in non- transfected: sc-117752 (A) and mouse GGT1 transfected: sc-120476 (B) 293T whole
cell ...
http://www.scbt.com/datasheet-120476-ggt1-m-293t-lysate.html...

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G3126 L-Glutamine ReagentPlus®, ≥99% (TLC)
assay, ≥99% (TLC). total impurities, <0.2% free ammonia. ~0.5% Glutamic acid. mp, 185 °C (dec.)(lit.) Gene Information, rat ... Ggt1(116568) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=G312...

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GGT Antibody / GGT Antibodies
GGT1/2 (A-14) Antikörper, sc-23823, goat IgG, C-terminus (h) ... GGT1 (3E6) Antikörper, sc-100746, mouse IgG2a, FL (h), WB, IP, IF, IHC(P), ELISA, m, r, h
...
http://www.scbt.com/de/table-ggt.html...

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