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PABPC1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17785442 |
Data show that TOB enhances mRNA deadenylation in vivo, and that interaction with PABPC1 is necessary for TOB's deadenylation-enhancing effect. |
| 18230761 |
Nonsense-mediated decay-sensitive mRNA can be stabilized by tethering the cytoplasmic poly(A) binding protein 1, PABPC1, at a premature termination codon-proximal position. |
| 17595167 |
the poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein |
| 11850402 |
Methylated in vivo by CARM1. Methylated region is mapped. |
| 15831480 |
PABP1 associates with paxillin in order to be efficiently transported from the nucleus to the cytoplasm; this event is necessary for cells to remodel their focal adhesions during cell migration. |
| 16782705 |
poly(A)-binding protein 1 (PABP) as a novel BRCA1-interacting protein. |
| 16332685 |
a novel signaling pathway involving MKK-2 and ERK1/2 may down-regulate the activity of PABP and eIF4E by controlling their phosphorylation and compensates for the effect of excess cellular PABP |
| 12565831 |
PABP1 is a potential substrate in MAPKAP kinase 2-induced mRNA stabilization. |
| 11997512 |
Paip1 interacts with poly(A) binding protein through two independent binding motifs. |
| 16716377 |
PABP interacts with HHV-8 K10/10.1 protein in infected primary effusion lymphoma (PEL) cell lines. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Eukaryotic translation initiation factor 4B | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
| HPRD | eukaryotic translation initiation factor 4B | Polyadenylate binding protein 1 | - | - | Pubmed |
| HPRD | eukaryotic translation initiation factor 4 gamma, 1 isoform 1 | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
| HPRD | eukaryotic translation initiation factor 4 gamma, 1 isoform 1 | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
| HPRD | G1 to S phase transition 1 | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
| HPRD | G1 to S phase transition 1 | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
| HPRD | Paxillin | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
| HPRD | paxillin gamma | Polyadenylate binding protein 1 | - | - | Pubmed |
| HPRD | PAN2 polyA specific ribonuclease subunit homolog | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
| HPRD | RACK1 | poly(A) binding protein, cytoplasmic 1 | - | - | Pubmed |
Recent Publications on PABPC1: |  |
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin {beta}
Mammalian mRNAs lose and acquire proteins throughout their life span while... | 4th November, 2009
| Department of Biochemistry and Biophysics and Center for RNA Biology,
| Genes Dev. 2009 Nov 1;23(21):2537-2550.
DOI Direct Link |
Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its sub-cellular distribution.
Human pathogenic viruses manipulate host cell translation machinery to... | 30th October, 2009
| Div. of Neurosurgery, Dept. of Surgery, Duke University Medical Center,
| J Virol. 2009 Oct 28.
DOI Direct Link |
The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of miRNA targets and is required for target release.
GW182 family proteins are essential in animal cells for miRNA-mediated... | 3rd October, 2009
| Max Planck Institute for Developmental Biology, Spemannstrasse 35, D-72076
| Mol Cell Biol. 2009 Sep 21.
DOI Direct Link |
Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.
Mouse spermatogenic cells are known to contain at least two isoforms of... | 26th June, 2009
| Graduate School of Life and Environmental Sciences, University of Tsukuba,
| Biol Reprod. 2009 Mar;80(3):545-54. Epub 2008 Nov 19.
DOI Direct Link |
Functional cloning of genes that suppress oxidative stress-induced cell death: TCTP prevents hydrogen peroxide-induced cell death.
We used retroviral-mediated expression cloning to identify cDNAs that... | 5th May, 2009
| Niigata University of Pharmacy and Applied Life Sciences (NUPALS),
| FEBS Lett. 2009 Apr 17;583(8):1363-7. Epub 2009 Mar 27.
DOI Direct Link |
→View more research publications. |
PABPC1 results (if any) from reagent suppliers | 
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PABPC 1
ImmuQuest Ltd: View Full information for PABPC 1. Alternative Description: PABPC 1. Catalogue Number: IQ216. Also known as: PABP; PAB 1; PABPC2; PABPL1; ...
http://www.immuquest.com/AntibodyDetails.asp?AntibodyID=580...
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IGF2BP1 antibody, IGF2BP1 (insulin-like growth factor 2 mRNA ...
The RNA-binding activity to ARS is stimulated by PABPC1. ... Interacts through the third and fourth KH domains with PABPC1 in a RNA-independent manner. ...
http://www.genwaybio.com/product_info.php?products_id=44208...
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PABP (N-20) Antibody sc-18610
Mouse, Pabpc1, 18458, 15 B3.1, P29341, N/A. Mouse, Pabpc2, 18459, 18 B3, NP_035163, N/A. Mouse, Pabpc4, 230721, 4 D2.2, NP_570951 ...
http://www.scbt.com/datasheet-18610-pabp-n-20-antibody.html...
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SYNCRIP antibody, SYNCRIP (synaptotagmin binding. cytoplasmic RNA ...
Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR, HNRPD and SYNCRIP. Isoform 3 interacts with HNRPR. ...
http://www.genwaybio.com/product_info.php?products_id=44203...
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PABP (H-300) Antibody sc-28834
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PABPC1, 26986, 8q22.3, NM_002568 ...
http://www.scbt.com/datasheet-28834-pabp-h-300-antibody.html...
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P6246 Monoclonal Anti-PABP antibody produced in mouse clone 10E10 ...
immunoprecipitation: suitable. microarray: suitable. isotype, IgG1. Gene Information, human ... PABPC1(26986). shipped in, dry ice. storage temp. −20°C
...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=P624...
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HNRNP C1/C2 antibody, HNRNP C1/C2 [4F4] Antibody, Mouse Monoclonal ...
... HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE,
...
http://www.genwaybio.com/product_info.php?products_id=190171...
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