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LAT


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Symbol:LAT
Name(s):linker for activation of T cells
Type:protein-coding
Organism:Homo sapiens
Synonyms:LAT1, pp36
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16464244 mapped the transcriptional start sites for the LAT gene and localized the 5' and 3' boundaries of the proximal promoter
17492476 LAT, ZAP-70, and DNMT1 protein levels in CD4(+) T cells can be associated with systemic lupus erythematosus.
17938199 These data indicate that following the rapid formation of signaling complexes upon T cell receptor stimulation, c-Cbl activity is involved in the internalization and possible downregulation of a subset of activated signaling molecules.
12029091 LAT displacement from lipid rafts is a molecular mechanism by which PUFAs inhibit T cell signaling
16236370 identify a novel post-translational modification of LAT by ubiquitination that is likely to influence LAT protein stability, intracellular localisation and/or recycling
12570875 interaction with open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells
15699071 Data show that the adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation.
16906159 In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL.
15029250 Results reveal the basis for preferential recognition of specific LAT sites by Gads.
15100278 CD3/T cell receptor complex signaling to beta 1 integrins is defective in LAT-deficient Jurkat T cells, and can be restored with expression of wild-type LAT.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD4 antigen precursorlinker for activation of T cells isoform a--Pubmed
HPRDCD4 antigen precursorlinker for activation of T cells isoform a--Pubmed
HPRDCD8 Antigen, alpha polypeptidelinker for activation of T cells isoform a--Pubmed
HPRDCD8 antigen alpha polypeptide isoform 1 precursorLAT--Pubmed
HPRDCD8 antigen alpha polypeptide isoform 1 precursorLinker for activation of T cells--Pubmed
HPRDFc gamma RIlinker for activation of T cells isoform a--Pubmed
HPRDFc fragment of IgG, high affinity Ia, receptorLAT--Pubmed
HPRDCD32linker for activation of T cells isoform a--Pubmed
HPRDFc fragment of IgG, low affinity IIa, receptor forLAT--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1linker for activation of T cells isoform a--Pubmed

Recent Publications on LAT:

Pubmed Logo
ESTIMATION OF SKIN ENTRANCE DOSES (SEDs) FOR COMMON MEDICAL X-RAY DIAGNOSTIC EXAMINATIONS IN INDIA AND PROPOSED DIAGNOSTIC REFERENCE LEVELS (DRLs).
Skin entrance doses (SEDs) were estimated by carrying out measurements of...
30th October, 2009
Radiological Safety Division, Atomic Energy Regulatory Board, Mumbai 400 Radiat Prot Dosimetry. 2009 Oct 28.
DOI Direct Link
Two new species of Sarcophaga s. lat. from Thailand with a key to species (Diptera: Sarcophagidae).
During a distribution survey of flies of medical importance around...
29th October, 2009
Department of Parasitology, Faculty of Medicine, Chiang Mai University, J Med Entomol. 2009 Sep;46(5):986-93.
Cannabinoid receptor type 1 and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.
The aim of this study was to characterize inhibitory mechanisms on T cell...
28th October, 2009
University of Magdeburg, Germany. J Biol Chem. 2009 Oct 26.
DOI Direct Link
Electromyographic analysis of three different types of lat pull-down.
The purpose of this work was to evaluate the activity of the primary motor...
27th October, 2009
Biomedical Engineering Program, COPPE/UFRJ, Rio de Janeiro, Brazil. J Strength Cond Res. 2009 Oct;23(7):2033-8.
DOI Direct Link
Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.
Understanding the mechanisms that coordinate the orientation of cell...
27th October, 2009
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Dev Cell. 2009 Oct;17(4):494-504.
DOI Direct Link

View more research publications.

Press Releases on LAT:

BioPortfolio Logo
Premier Herpes Dating Website, www.TwoCan.com, to Aid in Finding a Cure for Herpes 19th May, 2009 TwoCan.com

TwoCan.com Moves to Full Release and Arranges Donations to Duke University

MONROVIA, Calif., May 19 /PRNewswire/ -- TwoCan.com(TM) announces today

BioNews Results for LAT

: RSS Logo
BioPortfolio Logo
Human Pheromone Sciences Announces Third Quarter Results (Royalties from an expanded license agreement result in quarterly profit and improvement in
Yahoo! Canada:  Nov 14 2009 12:23AM Matching: lat
Amgen Hit With Suit Alleging Kickbacks Over Anemia Drug
Wall Street Journal Online:  Oct 30 2009 9:12PM Matching: lat
Plastic Surgeon Should Be On Cancer Team
WSBTV:  Oct 29 2009 5:10PM Matching: lat
Plastic Surgeon Should Be On Cancer Team
Boston Channel:  Oct 29 2009 2:17PM Matching: lat
Recordati : Positive First Nine Months 2009 Results, Sales And Income Increase
NewsBlaze:  Oct 27 2009 1:05PM Matching: lat
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Fluorine-18-α–Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer

Patents:

Patents logo
US Patent No.Title
7588926 Proteases
7596581 Relevance ranking of spatially coded documents
7596962 Shipping and installation for heating, ventilation, and air conditioning (HVAC)
7597654 Apparatus and methods for moveable exercise benches
7597663 Adjunctive ultrasound processing and display for breast cancer screening

View more patents.

LAT results (if any) from reagent suppliers

Google CSE Logo
LAT Antibody #9166
Immunohistochemical analysis of paraffin-embedded Jurkat cells, using LAT Antibody in the presence of control peptide (left) or antigen-specific peptide
...
http://www.cellsignal.com/products/9166.html...

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LAT Antibody / LAT Antibodies
LAT Antibody / LAT Antibodies. ... LAT specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-lat.html...

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Purified Anti-LAT Antibody - BioLegend
Purified Anti-LAT Antibody - LAT (linker for activation of T-cells) is a 36 kD phospho-tyrosine adaptor protein containing SH2 domains and a CVRC motif.
http://www.biolegend.com/purified-anti-lat-antibody-2532.htm...

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PathScan® Phospho-LAT (Tyr191) Sandwich ELISA Antibody Pair #7937
The LAT mouse capture antibody is coated onto a 96 well microplate overnight in PBS. After blocking, cell lysate is added followed by a phospho-LAT (Tyr191) ...
http://www.cellsignal.com/products/7937.html...

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Purified Anti-LAT Antibody - BioLegend
Purified Anti-LAT Antibody - LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors ...
http://www.biolegend.com/purified-anti-lat-antibody-5226.htm...

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Phospho-LAT (Tyr171) Antibody #3581
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide (KLH-coupled) corresponding to residues around Tyr171 of human
LAT. ...
http://www.cellsignal.com/products/3581.html...

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LAT (Q-20) Antibody sc-7548
See how others have used LAT (Q-20): sc-7548 antibody and or LAT (Q-20) ... Western blot analysis of LAT expression in BYDP whole cell lysates (A,B). ...
http://www.scbt.com/datasheet-7548-lat-q-20-antibody.html...

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