BioPortfolio - PDCD4 - programmed cell death 4 (neoplastic transformation inhibitor)

PDCD4

Symbol:

PDCD4

Name(s):

programmed cell death 4 (neoplastic transformation inhibitor)

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

H731, MGC33046, MGC33047

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

17828298

Downregulation of tumor suppressor Pdcd4 promotes colonic neoplastic transformation and tumor invasion

17991735

Programmed Cell Death 4 (PDCD4) is regulated by microrna miR-21 and demonstrate that PDCD4 is a functionally important target for miR-21 in breast cancer cells.

17849461

Loss of programmed cell death 4 expression is associated with colorectal cancer

17297470

These data suggest Pdcd4 as a new negative regulator of intravasation, and qas the invasion-related gene u-PAR. It is the first study to implicate Pdcd4 regulation of gene expression via Sp1/Sp3.

17053147

in response to mitogens, PDCD4 was rapidly phosphorylated by protein kinase S6K1 & then degraded by ubiquitin ligase SCF(betaTRCP); it is proposed that regulated degradation of PDCD4 in response to mitogens allows efficient protein synthesis & cell growth

15082783

Results indicate that not only binding to eIF4A but also prevention of eIF4A binding to the MA-3 domain of eIF4Gc contributes to the mechanism by which Pdcd4 inhibits translation.

16682950

data suggest that PDCD4 is a proapoptotic molecule involved in TGF-beta1-induced apoptosis in human HCC cells, and a possible tumor suppressor in hepatocarcinogenesis

12054647

up-regulated in senescent diploid fibroblasts

15317660

expression of pdcd4 as an indirect suppressor of CDK1/cdc2 is lost in progressed carcinomas of lung, breast, colon, and prostate

16449643

Pdcd4 suppresses tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription.

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