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BIN1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18154705 |
Mutated in recessive centronuclear myopathies. |
| 17210688 |
Mammary specific deletion of the Bin1 gene cooperates with ras activation to drive mammary tumor progression. The findings establish a role for Bin1 as a negative modifier of oncogenicity and progression in breast cancer. |
| 17699764 |
Mosaic knockout mice lacking Bin1 exhibit lung and liver cancer, increased inflammation or premalignant lesions in prostate, and more progressive colon cancer. Thus, Bin1 suppresses inflammation and cancer during aging. |
| 17611416 |
hob1+, the fission yeast homolog of Bin1, supports a mechanism of Rad6/Set1-dependent transcriptional repression that may relate to cancer suppression by Bin1. |
| 17676042 |
Results suggest that mutations in BIN1 cause centronuclear myopathy by interfering with remodeling of T tubules and/or endocytic membranes, and that the interaction between BIN1 and DNM2 is necessary for normal muscle function and positioning of nuclei. |
| 17676042 |
Mutations in amphiphysin 2 (BIN1) disrupt its membrane tubulation properties and its interaction with dynamin 2, and cause autosomal recessive centronuclear myopathy |
| 17671430 |
potential relevance of Bin1-Ku interaction to cancer are discussed in light of these findings |
| 17218774 |
Bin1 gene encodes a protein that suppresses neoplastic cell transformation.Bin1 may be a clinical prognostic marker in breast cancer. |
| 14704274 |
role in activating various target genes after induction with the microtubule disrupting agent T113242 |
| 12532338 |
Results document the extent of expression of nuclear Bin1 isoforms, which exhibit cancer suppression and proapoptotic activity in human cells. | →View more information from publications. |
Recent Publications on BIN1: |  |
The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer.
BACKGROUND: One of the putative mechanisms of tumor immune escape is based... | 23rd October, 2009
| State Key Laboratory of Oncology in South China, 651 Dongfeng R E, 510060,
| J Transl Med. 2009 Aug 20;7:71.
DOI Direct Link |
Bin1 SRC homology 3 domain acts as a scaffold for myofiber sarcomere assembly.
In skeletal muscle development, the genes and regulatory factors that... | 22nd October, 2009
| The Sprott Center for Stem Cell Research, Regenerative Medicine Program,
| J Biol Chem. 2009 Oct 2;284(40):27674-86. Epub 2009 Jul 26.
DOI Direct Link |
Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array.
Alterations of DNA methylation patterns have been suggested as biomarkers... | 12th September, 2009
| Laboratory for Prenatal Medicine and Gynecologic Oncology, Women's
| Oncogene. 2009 Aug 20;28(33):2969-78. Epub 2009 Jun 8.
DOI Direct Link |
Bin1 is linked to metastatic potential and chemosensitivity in neuroblastoma.
BACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumor... | 1st August, 2009
| Department of Surgery, Section of Pediatric Surgery, Riley Children's
| Pediatr Blood Cancer. 2009 Sep;53(3):332-7.
DOI Direct Link |
The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage.
The E2F1 transcription factor, which was originally identified as a... | 25th July, 2009
| [1] Division of Cancer Biology, Department of Pathology, School of
| Cell Death Differ. 2009 Jul 24.
DOI Direct Link |
→View more research publications. |
BIN1 results (if any) from reagent suppliers | 
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BIN1 antibody (ab27796) | Abcam
Rabbit polyclonal to BIN1. The identification and analysis of tumor suppressors is of major importance for improved diagnosis and treatment of tumors.
http://www.abcam.com/bin1-antibody-ab27796.html...
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www.hypromatrix.com Hypromatrix, Inc.
Bin 1 is highly homologous to Amphiphysin 2 protein. It is highly expressed in skeletal muscle. ... This antibody specifically recognizes Bin 1 as well as ...
http://www.hypromatrix.com/Products/Primary_Antibody/Bin1.pd...
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BIN1 antibodies: Microbiology > Interspecies Interaction > Host ...
BIN1 antibodies. ... BIN1 antibody [2F11]. IHC-P, IHC-Fr. Mouse monoclonal ... BIN1 antibody [99D]. Flow Cyt, ICC, IP, WB, ELISA, IHC-Fr ...
http://www.abcam.com/index.html?t=58635&pt=1&c=641&ei=&mu=ra...
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BIN Antibody / BIN Antibodies
Unlike Amph2, BIN1 expression is highest in skeletal muscle, and it contains an additional ... BIN1 interacts with the transcription factors c-Myc and MyoD, ...
http://www.scbt.com/table-bin.html...
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Tumor Suppressor Gene Products
B9428, Monoclonal Anti-Bin1 antibody produced in mouse clone 99D, ascites fluid, pricing. C1821, Monoclonal Anti-Pan Cadherin antibody produced in mouse ...
https://www.sigmaaldrich.com/etc/controller/controller-page....
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Amphiphysin II (2F11) Antibody sc-23918
Western blot analysis of Amphiphysin II and BIN1 splice variant of Amphiphysin II expression in IMR-32 (A) and HeLa (B) whole cell lysates. ...
http://www.scbt.com/datasheet-23918-amphiphysin-ii-2f11-anti...
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All Cell Cycle Inhibitors | Abcam
BIN1 antibody [2F11]. IHC-P, IHC-Fr. Mouse monoclonal. Reacts with: Hu. ab10532 · BIN1 antibody [99D]. Flow Cyt, ICC, IP, WB, ELISA, IHC-Fr ...
http://www.abcam.com/index.html?c=3461...
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