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GNA11
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17535809 |
two distinct regions of the Cav3.3 channel are necessary and sufficient for complete M1 receptor-mediated channel inhibition |
| 15863506 |
TPO integrates G(i), but not G(q), stimulation, supports integrin alpha(IIb)beta(3) activation platelet aggregation independently of phospholipase C but requires PI3-kinase and Rap1B |
| 15693018 |
regulation of the PLC pathway through the PTH1R is significantly increased by elevating expression of G(11)alpha in osteoblastic cells. |
| 16611642 |
the ability of MAS to up-regulate AT(1) receptor levels reflects the constitutive capacity of MAS to activate Galpha(q)/Galpha(11) and hence stimulate PKC-dependent phosphorylation of the AT(1) receptor |
| 12759536 |
GNA11 is involved in signalling of gonadotropin-releasing hormone receptor, which negatively regulates cell growth. Down-regulation is suggested to be involved in human breast cancers. |
| 16350855 |
soluble amyloid precursor protein release enhancement induced by muscarinic receptor stimulation was decreased by a G(q/11) minigene construct |
| 16723377 |
G(q/11)-coupled receptors are the principal G protein-coupled receptor subfamily mediating cooperative mitogenic signaling in airway smooth musscle. |
| 12130679 |
the C-terminal domain participates intimately in the efficacy of B1R and B2R G(q/11) coupling by contributing both positive and negative regulatory epitopes. |
| 16365309 |
CB(1) receptors are stabilized in a conformation that enables G(q)11 signaling by the WIN55212-2 cannabinoid agonist, thus shifting the G protein specificity of the receptor |
| 15632174 |
a new signaling pathway by which G alpha(q/11)-coupled receptors specifically induce Rho signaling through a direct interaction of activated G alpha(q/11) subunits with p63RhoGEF. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | alpha-1B-adrenergic receptor | guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | alpha-1B-adrenergic receptor | guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | Beta-2-adrenergic receptor | guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | adrenergic, beta-2-, receptor, surface | Guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | Cholinergic receptor, muscarinic 2 | guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | cholinergic receptor, muscarinic 2 | Guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | Endothelin receptor, type A | guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | endothelin receptor type A | Guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | endothelin receptor type B isoform 1 precursor | Guanine nucleotide binding protein, alpha 11 | - | - | Pubmed |
| HPRD | Guanine nucleotide binding protein, alpha 11 | 5-hydroxytryptamine receptor 2A | - | - | Pubmed |
Recent Publications on GNA11: |  |
Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation.
Neuroglobin (Ngb) is a tissue globin specifically expressed in neurons.... | 17th September, 2009
| Neuroprotection Research Laboratory, Department of Neurology and
| Neuroscience. 2009 Aug 18;162(2):396-403. Epub 2009 May 3.
DOI Direct Link |
Independent regulation of hair and skin color by two G protein-coupled pathways.
Hair color and skin color are frequently coordinated in mammalian species.... | 25th July, 2009
| Department of Medical Genetics, University of British Columbia, Vancouver,
| Pigment Cell Melanoma Res. 2009 Dec;22(6):819-26. Epub 2009 Jul 21.
DOI Direct Link |
RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.
The heterotrimeric G-protein pathway controls numerous cellular processes,... | 7th January, 2009
| Laboratory of Reproductive Medicine, Department of Histology and
| Biol Reprod. 2008 Dec;79(6):1021-9. Epub 2008 Aug 13.
DOI Direct Link |
Cloning, expression pattern, chromosomal localization, and evolution analysis of Porcine gnaq, gna11, and gna14.
The Gq class is one subfamily of the G protein alpha subunits multigene... | 30th August, 2008
| Key Laboratory of Agricultural Animal Genetics, Breeding, and
| Biochem Genet. 2008 Aug;46(7-8):398-405. Epub 2008 Mar 11.
DOI Direct Link |
Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.
Germline knockout of the extracellular Ca2+ -sensing receptor (CaR) leads... | 21st February, 2007
| Pharmakologisches Institut der Universitat Heidelberg, Im Neuenheimer Feld
| Mol Endocrinol. 2007 Jan;21(1):274-80. Epub 2006 Sep 20.
DOI Direct Link |
→View more research publications. |
GNA11 results (if any) from reagent suppliers | 
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GNAQ+ GNA11 antibodies: Signal Transduction > Signaling Pathway ...
GNAQ+ GNA11 antibodies. ... Image Abreview Publication. ab79337 · GNAQ+ GNA11 antibody. IP, WB. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=277132&pt=1&c=2166&ei=&mu=...
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Gα 11 (D-17) Antibody sc-394
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GNA11, 2767, 19p13.3, NM_002067 ...
http://www.scbt.com/datasheet-394-galpha-11-d-17-antibody.ht...
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GNAQ antibody (ab75825) | Abcam
(species key). Dog, Pig, Xl (Due to sequence homology). Specificity. The immunogen has 66% homology with GNA11. Tested applications (see key). ICC/IF, WB
...
http://www.abcam.com/g-protein-alpha-q-11-antibody-ab75825.h...
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Gα i/o/t/z (D-15) Antibody sc-12798
Mouse, Gna11, 14672, 10 C1, P21278, N/A. Mouse, Gna13, 14674, 11 E1, P27601, N/A . Mouse, Gna14, 14675, 19 A, P30677, N/A. Mouse, Gna15, 14676, 10 C1, P30678 ...
http://www.scbt.com/datasheet-12798-galpha-i-o-t-z-d-15-anti...
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Abcam antibodies and reagents product map
... GNAQ antibodies (1) · GNAQ + GNA11 antibodies (1) · GNB1 antibodies (2) · GNB1 proteins and peptides (1) · GNB1L antibodies (1) · GNB2 antibodies (4) ...
http://www.abcam.com/index.html?c=2105...
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Gα q/11 (C-19) Antibody sc-392
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Gna11, 14672, 10 C1, P21278 ...
http://www.scbt.com/datasheet-392-galpha-q-11-c-19-antibody....
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< 다음 5 논문 >
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology. 64: 380-388. PubMed Entry 보기. Masuda, Kazuyuki et al. 2003. ...
http://www.scbt.com/ko/product.php?datasheet=394&page=2&tota...
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