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GNAI1
| Symbol: | GNAI1 | | Name(s): | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | Gi | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18037379 |
Heretotrimeric G protein subunit Galphai is associated with mitochondria. |
| 17646583 |
Selective induction of G alpha inhibiting subunit 1 (Gi alpha1) expression is a novel downstream event in hypertrophic signaling that may be a critical factor leading to cellular electrophysiological remodeling of the Ras transgenic mouse heart. |
| 15863506 |
TPO integrates G(i), but not G(q), stimulation, supports integrin alpha(IIb)beta(3) activation platelet aggregation independently of phospholipase C but requires PI3-kinase and Rap1B |
| 12297512 |
co-stimulation of G(12/13) and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets in a mechanism that involves intracellular calcium |
| 14602724 |
Gi has a role in insulin attenuation of platelet functions by interfering with cAMP suppression along with IRS-1 |
| 17267663 |
These data revealed that PAR1 can be part of a preassembled complex with Galpha(i1) protein, resulting either from a direct interaction between these partners or from their colocalization in specific microdomains. |
| 14576516 |
An age-induced increase in G alpha i may have a role in depressing cardiac function in aged human atria. |
| 15837785 |
G12, Rho, filamin-A, and the actin cytoskeleton are required for amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor |
| 11976690 |
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits |
| 14623889 |
Gi, but not Gq or G12/13, signaling pathways are required for activation of Akt in platelets | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Adenylate cyclase 5 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | adenylate cyclase 5 | G protein, alpha inhibiting 1 | - | - | Pubmed |
| HPRD | alpha-2A-adrenergic receptor | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | alpha-2A-adrenergic receptor | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | CD47 antigen isoform 1 precursor | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | central cannabinoid receptor isoform a | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | central cannabinoid receptor isoform a | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | Corticotropin releasing hormone receptor 1 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
| HPRD | corticotropin releasing hormone receptor 1 | G protein, alpha inhibiting 1 | - | - | Pubmed |
| HPRD | Dopamine receptor D3 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | - | - | Pubmed |
Recent Publications on GNAI1: |  |
Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK.
We have earlier shown that the treatment of A10 vascular smooth muscle... | 18th July, 2009
| Department of Physiology, Groupe de recherche sur le systeme nerveux
| Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1859-67. Epub 2009 Feb
DOI Direct Link |
Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
Downregulation of the sarcoplasmic reticulum calcium ATPase (SERCA2) is... | 10th April, 2009
| Univ. of California, San Diego, Dept. of Pharmacology, 9500 Gilman Dr., La
| Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H728-34. Epub 2009 Jan
DOI Direct Link |
Distinct subsets of hypothalamic genes are modulated by two different thermogenesis-inducing stimuli.
Obesity results from an imbalance between food intake and energy... | 9th September, 2008
| Department of Internal Medicine, State University of Campinas, Sao Paulo,
| Obesity (Silver Spring). 2008 Jun;16(6):1239-47. Epub 2008 Mar 20.
DOI Direct Link |
Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3.
A range of ligands displayed agonism at the long isoform of the human... | 30th May, 2007
| Molecular Pharmacology Group, Division of Biochemistry and Molecular
| Mol Pharmacol. 2007 May;71(5):1349-59. Epub 2007 Feb 7.
DOI Direct Link |
Improving the comparative map of porcine chromosome 9 with respect to human chromosomes 1, 7 and 11.
Conserved segments have been identified by ZOO-FISH between pig chromosome... | 21st June, 2004
| Centre for Advanced Technologies in Animal Genetics and Reproduction,
| Cytogenet Genome Res. 2003;102(1-4):128-32.
DOI Direct Link |
→View more research publications. |
GNAI1 results (if any) from reagent suppliers | 
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Gα i-1 (I-20) Antibody sc-391
Mouse, Gnai1, 14677, 5 A3, NP_034435, N/A. Mouse, Gnai2, 14678, 9 F1, P08752, N/ A. Mouse, Gnai3, 14679, 3 F2.3, Q9DC51 ...
http://www.scbt.com/datasheet-391-galpha-i-1-i-20-antibody.h...
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Abgent - Neurosciences Antibodies
AT2225aNEW, GNAI1 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Re, H. AT2247aNEW, GPR24 monoclonal antibody (M01), ELISA,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/neurosciences...
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