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GNAI2
| Symbol: | GNAI2 | | Name(s): | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16565233 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15640523 |
the Galphai2 gene promoter is transcriptionally activated through nuclear factor-kappaB and antioxidant response elements |
| 14701866 |
Galphai2 has a role in calcium-sensing receptor-mediated ERK1/2 activation |
| 12088413 |
CXCL12 upregulated T-cell activation, and an alpha(i) G-coupled protein mediated signaling pathway was necessary for stimulation of T cells by CXCL12. |
| 14623802 |
Cholesterol lowering by pravastatin might increase the response of the heart to parasympathetic stimulation and changes in Galpha(i2) expression might serve as a molecular marker for this effect |
| 15126921 |
Abnormal regulation of GNAI2 was studied in cultured skin fibroblasts from insulin-resistant hypertensive individuals. |
| 12359238 |
Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2 |
| 12624107 |
valproic acid-induced expression of Galphai2 is regulated by Sp1 transcription factor |
| 15331550 |
in elderly subjects of similar ages, those with diabetes have 1.7-fold higher levels of Galpha(i2) and twofold higher levels of Gbeta(1). |
| 16565233 |
a GNAI2 -318 C>G SNP impairs transcriptional activity through specific binding of Sp1 and is associated with high SBP in Caucasians from Italy | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | adenosine A1 receptor | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | adenosine A1 receptor | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | alpha-2B-adrenergic receptor | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | alpha-2B-adrenergic receptor | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | complement component 5 receptor 1 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | complement component 5 receptor 1 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | Cholinergic receptor, muscarinic 1 | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | cholinergic receptor, muscarinic 1 | GNAI2 | - | - | Pubmed |
| HPRD | central cannabinoid receptor isoform a | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
| HPRD | central cannabinoid receptor isoform a | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 | - | - | Pubmed |
Recent Publications on GNAI2: |  |
Alterations in myeloid dendritic cell innate immune responses in the Galphai2-deficient mouse model of colitis.
BACKGROUND: The G protein alpha subunit type-2 (Galpha(i)2)-deficient... | 25th July, 2009
| Department of Pathology, Baylor College of Medicine, Houston, Texas 77030,
| Inflamm Bowel Dis. 2009 Feb;15(2):248-60.
DOI Direct Link |
Intestinal mucosal inflammation leads to systemic genotoxicity in mice.
Inflammatory bowel disease, including ulcerative colitis and Crohn's... | 16th July, 2009
| Departments of Molecular Toxicology, University of California at Los
| Cancer Res. 2009 Jun 1;69(11):4827-34.
DOI Direct Link |
GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.
Noonan syndrome (NS OMIM 163950) is a relatively common autosomal dominant... | 25th June, 2009
| Department of Pharmacology, University of Michigan, 1301 MSRB III, Ann
| Med Hypotheses. 2009 Jul;73(1):56-9. Epub 2009 Mar 17.
DOI Direct Link |
B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.
Sphingosine-1-phosphate (S1P) helps mediate lymphocyte egress from lymph... | 10th April, 2009
| B-Cell Molecular Immunology Section, Laboratory of Immunoregulation,
| Immunity. 2009 Mar 20;30(3):434-46. Epub 2009 Feb 19.
DOI Direct Link |
Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations.
BACKGROUND: Mutations of the genes encoding the alpha subunit of the... | 11th March, 2009
| Department of Medicine and Pharmacology, Section of Endocrinology,
| J Endocrinol Invest. 2008 Nov;31(11):946-9.
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→View more research publications. |
GNAI2 results (if any) from reagent suppliers | 
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Gα i/o/t/z (D-15) Antibody sc-12798
Mouse, Gnai2, 14678, 9 F1, P08752, N/A. Mouse, Gnai3, 14679, 3 F2.3, Q9DC51, N/A . Mouse, Gnao1, 14681, 8 C5, P18872, N/A. Mouse, Gnaq, 14682, 19 A, P21279 ...
http://www.scbt.com/datasheet-12798-galpha-i-o-t-z-d-15-anti...
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Panorama® Antibody Array - Signal Transduction
GNAI2. guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. 2771 · GNAI3. guanine nucleotide binding protein (G protein) ...
http://www.sigmaaldrich.com/life-science/cell-biology/protei...
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Gα i-1/2/3 (N-20) Antibody sc-26761
Human, GNAI2, 2771, 3p21.31, NM_002070 · P04899 · 192605. Human, GNAI3, 2773, 1p13.3, NM_006496 · P08754 ... Mouse, Gnai2, 14678, 9 F1, P08752 ...
http://www.scbt.com/datasheet-26761-galpha-i-1-2-3-n-20-anti...
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Gβ (T-20) Antibody sc-378
Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol. Cell. Biol. 26(18): 6870-6879. View PubMed Entry ...
http://www.scbt.com/datasheet-378-gbeta-t-20-antibody.html...
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Gα i-1 (I-20) Antibody sc-391
Mouse, Gnai2, 14678, 9 F1, P08752, N/A. Mouse, Gnai3, 14679, 3 F2.3, Q9DC51, N/A . Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List ...
http://www.scbt.com/datasheet-391-galpha-i-1-i-20-antibody.h...
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