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CXCR3
| Symbol: | CXCR3 | | Name(s): | chemokine (C-X-C motif) receptor 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10, IP10-R, Mig-R, MigR | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18280341 |
CXCR3 <-> ligand-mediated lymphocyte recruitment is involved in cutaneous lichenoid graft-versus-host disease. |
| 16043121 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17560677 |
In chronic hepatitis C, anti-viral treatment induces an increase in CD8+ cells expressing chemokine receptors. Viral control is associated with an increase in CXCR3(high) expressing CD8+ cells during treatment. |
| 18037659 |
In clinically inflamed dental pulp, CXCR3 expression was observed mainly on T-cells. |
| 17615381 |
T cells expressing CCR6, CXCR3, and CXCR6 act coordinately with respective ligands and Th1 inflammatory cytokines in the alveolitic/granuloma phases of the disease. |
| 17947699 |
IKK2 is also involved in the IFN-gamma-stimulated release of the CXCR3 ligands through a novel mechanism that is independent NF-kappaB |
| 17912012 |
CXCR3 was expressed strongly at the acinar cell membrane in chronic pancreatitis as compared to normal |
| 17018607 |
Activation of Ras plays a critical role in modulating the expression of both CXCL10 and CXCR3-B, which may have important consequences in the development of breast tumors through cancer cell proliferation. |
| 17363734 |
CD13 rapidly processed CXCL11, but not CXCL8, to generate truncated CXCL11 forms that had reduced binding, signaling, and chemotactic properties for lymphocytes and CXCR3- or CXCR7-transfected cells. |
| 12270371 |
Gene expression is predictive for the individual response of children with chronic allograft nephropathy to mycophenolate mofetil. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | CXC chemokine receptor type 3 | small inducible cytokine B10 precursor | - | - | Pubmed |
| HPRD | CXC chemokine receptor type 3 | small inducible cytokine B9 precursor | - | - | Pubmed |
| HPRD | Homo sapiens CXC chemokine receptor transcript variant B mRNA, complete cds, alternatively spliced | Chemokine CXC motif ligand 9 | - | - | Pubmed |
| HPRD | Homo sapiens CXC chemokine receptor transcript variant B mRNA, complete cds, alternatively spliced | Interferon-gamma-inducible protein 10 | - | - | Pubmed |
| HPRD | Homo sapiens CXC chemokine receptor transcript variant B mRNA, complete cds, alternatively spliced | small inducible cytokine B11 precursor | - | - | Pubmed |
| HPRD | Homo sapiens CXC chemokine receptor transcript variant B mRNA, complete cds, alternatively spliced | small inducible cytokine B11 precursor | - | - | Pubmed |
| HPRD | Homo sapiens CXC chemokine receptor transcript variant B mRNA, complete cds, alternatively spliced | chemokine ligand 13 | - | - | Pubmed |
| HPRD | Homo sapiens CXC chemokine receptor transcript variant B mRNA, complete cds, alternatively spliced | chemokine ligand 13 | - | - | Pubmed |
Recent Publications on CXCR3: |  |
Upregulation of Stromal cell derived factor-1alpha in Collagen Vascular Diseases - associated interstitial pneumonias (CVDs-IPs).
OBJECTIVE: We speculated that distinct angiogenic profiles are involved in... | 3rd November, 2009
| Department of Thoracic Medicine, Interstitial Lung Disease Unit, Medical
| Pulm Pharmacol Ther. 2009 Oct 27.
DOI Direct Link |
I-TAC is a dominant chemokine in controlling skin intragraft inflammation via recruiting CXCR3(+) cells into the graft.
Chemokines play a critical role in the acute transplant rejection. In... | 31st October, 2009
| Department of Immunology, Institute for Immunobiology, Shanghai Medical
| Cell Immunol. 2009 Sep 11.
DOI Direct Link |
Chemokine receptor blockade with a synthetic nonpeptide compound attenuates cardiac allograft vasculopathy.
BACKGROUND.: Recruitment of recipient mononuclear cells to the donor heart... | 27th October, 2009
| Department of Surgery, Division of Cardiothoracic Surgery, David Geffen
| Transplantation. 2009 Oct 27;88(8):995-1001.
DOI Direct Link |
Expression of CXCL9, CXCL10, and CXCL11, and CXCR3 in the Tear Film and Ocular Surface of Patients with Dry Eye Syndrome.
Purpose: To investigate the expression of CXCL9, CXCL10, CXCL11, and CXCR3... | 24th October, 2009
| Chonnam National University Medical School and Hospital, Department of
| Invest Ophthalmol Vis Sci. 2009 Oct 22.
DOI Direct Link |
Peripheral CXCR3-Associated Chemokines as Biomarkers of Fibrosis in Chronic Hepatitis C Virus Infection.
Background. CXCR3-associated chemokines CXCL9-CXCL11 promote histologic... | 24th October, 2009
| Division of Gastroenterology and Hepatology and Center for the Study of
| J Infect Dis. 2009 Oct 22.
DOI Direct Link |
→View more research publications. |
CXCR3 results (if any) from reagent suppliers | 
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PE Anti-mouse CD183 CXCR3 Antibody Anti-CD183 - BioLegend
PE Anti-mouse CD183 CXCR3 Antibody Anti-CD183 - CD183, also known as CXCR3, is a member of CXC chemokine family characterized by a pair of cysteine residues ...
http://www.biolegend.com/pe-anti-mouse-cd183-cxcr3-antibody-...
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mouse CD183/CXCR3 antibody, Allophycocyanin (APC) conjugate
eBioscience technical data sheet for product 17-1831 Allophycocyanin (APC) anti- mouse CD183 (CXCR3) CXCR3-173 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_17/17-...
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C1366 Anti-CXCR3 antibody produced in rabbit affinity isolated ...
C1366 Anti-CXCR3 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution.
https://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=e...
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Pacific Blue Anti-human CD183 CXCR3 Antibody Anti-CD183 - BioLegend
Pacific Blue Anti-human CD183 CXCR3 Antibody Anti-CD183 - CXCR3 highly expressed by T lymphocytes (Th1),natural killer cells (NK cells), dendritic cells, ...
http://www.biolegend.com/pacific-blue-anti-human-cd183-cxcr3...
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CXCR3 antibody [2Ar1] (ab64714) | Abcam
Mouse monoclonal [2Ar1] to CXCR3. CXCR3 is a receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
http://www.abcam.com/CXCR3-antibody-2Ar1-ab64714.html...
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C6473 Monoclonal Anti-CXCR3 antibody produced in mouse clone ...
C6473 Monoclonal Anti-CXCR3 antibody produced in mouse clone 49801.111, purified immunoglobulin, lyophilized powder.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C647...
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Human CXCR3 MAb (Clone 49801)
myeloma with B cells obtained from a mouse inoculated with human CXCR3- transfected. NS0 mouse myeloma cells. The IgG fraction of ascites fluid was
purified ...
http://www.rndsystems.com/pdf/mab160.pdf...
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