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ANGPT1


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Gene DB Home
Symbol:ANGPT1
Name(s):angiopoietin 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:AGP1, AGPT, ANG1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18326231 Stromal sublayer of AA patients is characterized by low expression of Ang-1 and VCAM-1 genes and high VEGF expression compared to mean level of healthy donors.
17943167 AML cells are a major source of Ang-1 in leukemic bone marrow, especially in patients with NPM1 mutations, but the local levels are also influenced by stromal cells
17603084 Ang1-transduced osteogenically differentiated mesenchymal stem cells may be suitable for inducing neovascularization in bone tissue engineering applications.
18035072 Observational study of gene-disease association. (HuGE Navigator)
18080866 These results indicate that Ang-1 triggers coordinated responses in endothelial cells designed to inhibit the expression of proapoptotic and antiproliferative genes and up-regulate proproliferative, proangiogenic, and antiapoptotic pathways.
17724803 Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas.
17728252 Activation of Tie1 ectodomain cleavage increases cartilage oligomeric protein angiopoietin 1 activation of Tie2.
17803352 Administration of murine mesenchymal stem cells transfected with human ANGPT1 results in nearly complete reversal of lipopolysaccharide-induced increases in experimental lung inflammation and permeability.
17785951 Decreased expression of Ang-1 may be responsible for blood vessel formation and rapid growth of the colorectal adenocarcinoma.
17562701 Ang-1 prevents vascular permeability by regulating the endothelial cytoskeleton through coordinated and opposite effects on the Rho GTPases Rac1 and RhoA

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BIND-TEK tyrosine kinase, endothelialTie2 interacts with Ang1.-Pubmed
HPRDAngiopoietin1angiopoietin 2 isoform a precursor--Pubmed
HPRDangiopoietin 1Angiopoietin 2--Pubmed
HPRDangiopoietin 1TEK tyrosine kinase, endothelial--Pubmed
HPRDangiopoietin 1TEK tyrosine kinase, endothelial--Pubmed

Recent Publications on ANGPT1:

Pubmed Logo
FIBROBLAST GROWTH FACTOR-2 ENHANCES PROLIFERATION AND DELAYS LOSS OF CHONDROGENIC POTENTIAL IN HUMAN ADULT BONE MARROW-DERIVED MESENCHYMAL STEM CELLS.
We compared human mesenchymal stem cells (hMSCs), expanded long-term with...
22nd October, 2009
Case Western Reserve University, General Medical Sciences: Hematology and Tissue Eng Part A. 2009 Oct 20.
DOI Direct Link
The transport of high amounts of vascular endothelial growth factor by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis.
OBJECTIVES: Altered angiogenesis is a characteristic feature in SSc and...
10th October, 2009
Inserm U889, IFR 66, Bordeaux, France. Rheumatology (Oxford). 2009 Sep;48(9):1036-44. Epub 2009 Jun 23.
DOI Direct Link
Localization of Angiopoietin-1 and Tie2 Immunoreactivity in Rodent Ependyma and Adjacent Blood Vessels Suggests Functional Relationships.
Angiopoietin-1 (Angpt1; previously Ang-1) participates in vascular...
30th September, 2009
Department of Neurology, University of Alabama at Birmingham, Birmingham, J Histochem Cytochem. 2009 Sep 28.
DOI Direct Link
Differential gene expression profiles of whole lesions from patients with oral lichen planus.
BACKGROUND: The molecular biological properties of oral lichen planus...
25th September, 2009
Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat-sen J Oral Pathol Med. 2009 May;38(5):427-33. Epub 2009 Mar 9.
DOI Direct Link
Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes.
AIMS: The aim of the study was to evaluate the histopathology of...
4th September, 2009
Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland. Br J Ophthalmol. 2009 Aug;93(8):1109-15. Epub 2009 Mar 19.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7485418 Aberrantly methylated genes in pancreatic cancer
7442390 Method for enhancing engraftment of cells using mesenchymal progenitor cells
7371384 Compositions and methods of using angiopoietin-like 4 protein antibody
7049072 Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state

View more patents.

ANGPT1 results (if any) from reagent suppliers

Google CSE Logo
Ang-1 (C-19) Antibody sc-6320
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ANGPT1, 284, 8q23.1, NM_001146 ...
http://www.scbt.com/datasheet-6320-ang-1-c-19-antibody.html...

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ELF3 antibody, E74-like factor 3 (ets domain transcription factor ...
Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase ...
http://www.genwaybio.com/product_info.php?products_id=60074...

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Ang-1/4 (C-19) Antibody sc-9360
Mouse, Angpt1, 11600, 15 B3.1, O08538, N/A. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. Ang-1/4 (C-19), sc-9360, 200 µg/ml ...
http://www.scbt.com/datasheet-9360-ang-1-4-c-19-antibody.htm...

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BIOMOL International - Angiopoietin-1 (human, recombinant)
Recombinant human glycosylated angiopoietin-1 (Ang1, Angpt1) comprising amino acids 21-496, with an N-terminal purification tag. Angiopoietin-1 is secreted
...
http://www.biomol.com/?pageId=38&categoryId=1110&productId=3...

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Ang Antibody / Ang Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. Ang (H-98) Antibody, sc-8357, rabbit IgG, 400-498 (h), WB, IP, IF, ELISA, m, r, h ...
http://www.scbt.com/table-ang.html...

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Akt Pathway Products
Extracellular Growth Factors/Cytokines. Gene Symbol. ANGPT1 · FGF8 · LHB · ANG1 · FGF9 · NTF5 · ANGPT2 · FGF10 · PDGFA · ANGPT4 · FGF16 · PDGFB ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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JAK-STAT Signaling Pathway
EPHB4 · IL13RA (CD213A1), TYRO3 · ERBB2 (Her2), INSR (CD220). ERBB4 (Her4), INSRR. Cytokine Proteins. Gene Symbol. ANGPT1 · FGF1 · IL5 · ANGPT2 · FGF2 · IL6
...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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