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LAMA1


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Gene DB Home
Symbol:LAMA1
Name(s):laminin, alpha 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:LAMA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18162078 Real-time PCR showed that ETOH significantly altered the expression of genes involved in cell adhesion. There was an increase in the expression of alpha and beta Laminins 1, beta Integrins 3 and 5, Secreted phosphoprotein1 and Sarcoglycan epsilon.
17618648 analysis of how distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms
17307732 analysis of structure and activities reveal differences in laminin G-like domain interactions that should enable dissection of biological roles of different laminin ligands
15885076 adhesion to laminin-1 through alpha6-integrin represents a protective mechanism for melanocytes to withstand UVB damage
12615822 mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions.
12393739 Laminins with alpha1, alpha4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.
11827968 Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression.
12111806 Alpha 1 laminin was heavily over-expressed in Alzheimer disease frontal cortex, and localized in reactive astrocytes of the grey and white matter, and as punctate deposits in the senile placques of the Alzheimer brain tissue.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAcetylcholinesteraselaminin, alpha 1 precursor--Pubmed
HPRDacetylcholinesterase isoform E4-E5 precursorLaminin, alpha 1--Pubmed
HPRDamyloid beta A4 protein precursor, isoform alaminin, alpha 1 precursor--Pubmed
HPRDFibulin 2laminin, alpha 1 precursor--Pubmed
HPRDfibulin 2 precursorLaminin, alpha 1--Pubmed
HPRDPerlecanlaminin, alpha 1 precursor--Pubmed
HPRDheparan sulfate proteoglycan 2Laminin, alpha 1--Pubmed
HPRDIntegrin alpha 1laminin, alpha 1 precursor--Pubmed
HPRDintegrin, alpha 1 precursorLaminin, alpha 1--Pubmed
HPRDIntegrin alpha 2laminin, alpha 1 precursor--Pubmed

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7129052 Peptides and their utility in modulation of behavior of cells expressing .alpha.3.beta.1 integrins
6955924 Laminin chains: diagnostic uses

View more patents.

LAMA1 results (if any) from reagent suppliers

Google CSE Logo
Antibodies to Extracellular Matrix Proteins
mouse ... Lama1(16772), animal, human, ARR, DB, IF (i), IHC (p), pricing. L4669, Anti-Lysyl Oxidase (C-terminal) antibody produced in rabbit, (polyclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Laminin α-1 (H-300) Antibody sc-5582
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, LAMA1, 284217, 18p11.31, NM_005559 ...
http://www.scbt.com/datasheet-5582-laminin-alpha-1-h-300-ant...

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L9393 Anti-Laminin antibody produced in rabbit affinity isolated ...
microarray: suitable. Gene Information, human ... LAMA1(284217). mouse ... Lama1 (16772). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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ExactaChIP™ Mouse SOX17 Chromatin Immunoprecipitation Kit
Mouse Lama1 Forward Primer (Part 965951) - 50 mL at 20 pmol/mL .... Lama1 promoter, as shown in the Typical Data section on page 7, is: 43 cycles, ...
http://www.rndsystems.com/pdf/ECP1924.pdf...

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BTEB2 (A-16) Antibody sc-12998
Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain. J. Biol. Chem. 279: 9103-9114. View PubMed Entry. Bidder, M. et al. 2002. ...
http://www.scbt.com/datasheet-12998-bteb2-a-16-antibody.html...

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L8271 Monoclonal Anti-Laminin antibody produced in mouse clone LAM ...
LAMA1(284217), LAMA2(3908), LAMB1(3912), LAMB2(3913). shipped in, dry ice. storage temp. −20°C. Safety. WGK Germany, 3. References ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=L827...

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Citations Search
Notes: The pGL3-basic and pGL3-Promoter vectors were used to make constructs with varying lengths of the mouse LAMA1 promoter. Gene fragments up to 6.1 kb
...
http://www.promega.com/citations/default.aspx?citapp=e1761...

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