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ANGPT2


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Gene DB Home
Symbol:ANGPT2
Name(s):angiopoietin 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:AGPT2, ANG2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17943167 Local Ang-2 release from AML cells is less common than Ang-1 release, but high systemic levels of Ang-2 may affect bone marrow angioregulation.
17704802 Regulates vascular endothelial growth factor expression at the transcriptional level in relation to a decrease in hypoxia-inducible factor 1 alpha (HIF) expression and HIF-DNA-binding activity.
14556828 Observational study of gene-disease association. (HuGE Navigator)
15694966 Observational study of gene-disease association. (HuGE Navigator)
16009172 Observational study of gene-disease association. (HuGE Navigator)
16877277 Observational study of gene-disease association. (HuGE Navigator)
17630849 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17724803 Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas.
17785951 Increased expression of Ang-2 may be responsible for blood vessel formation and rapid growth of the colorectal adenocarcinoma.
17673702 Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAngiopoietin1angiopoietin 2 isoform a precursor--Pubmed
HPRDangiopoietin 1Angiopoietin 2--Pubmed
HPRDangiopoietin 2 isoform a precursorTEK tyrosine kinase, endothelial--Pubmed
HPRDangiopoietin 2 isoform a precursorTEK tyrosine kinase, endothelial--Pubmed
BINDangiopoietin 2 isoform a precursorTEK tyrosine kinase, endothelialTie2 interacts with Ang2.-Pubmed
BINDangiopoietin 2 isoform a precursorTEK tyrosine kinase, endothelialThe receptor binding domain (RBD) of Ang2 interacts with the Tie2 ligand binding domain (LBD). This interaction was modelled on a demonstrated interaction between human Ang2 and Tie2 from an unspecified species.-Pubmed

Recent Publications on ANGPT2:

Pubmed Logo
Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis.
Before metastasis, certain organs have already been influenced by primary...
24th September, 2009
Cancer Biology Laboratory and Beijing Key Laboratory of Protein Cancer Res. 2009 Oct 1;69(19):7529-37. Epub 2009 Sep 22.
DOI Direct Link
Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS.
OBJECTIVE: Angiopoietin-2 (Ang-2) is a potent regulator of vascular...
2nd September, 2009
Department of Environmental Health, Harvard School of Public Health, 665 Intensive Care Med. 2009 Jun;35(6):1024-30. Epub 2009 Mar 7.
DOI Direct Link
Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium.
OBJECTIVE: To evaluate the expression of vascular endothelial growth...
9th July, 2009
Department of Obstetrics and Gynecology, University of Naples Federico II, Fertil Steril. 2009 Jun;91(6):2315-23. Epub 2008 Jul 21.
DOI Direct Link
Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling.
Infantile hemangiomas are characterized by rapid capillary growth during...
20th May, 2009
Department of Pathology, Children's Hospital Boston, Boston, Massachusetts Am J Pathol. 2009 May;174(5):1638-49. Epub 2009 Apr 6.
DOI Direct Link
Angiogenic mediators of the angiopoietin system are highly expressed by CD10-positive lymphoma cells in angioimmunoblastic T-cell lymphoma.
Angioimmunoblastic T-cell lymphoma (AILT) is a malignant disease of...
15th May, 2009
Department of Comprehensive Pathology, Ageing and Developmental Sciences, Br J Haematol. 2009 Mar;144(5):696-704. Epub 2008 Dec 12.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
A Trial Of CVX-060, An Anti-Angiogenic COVX-Body, In Combination With Sunitinib In Patients With Advanced Renal Cell Carcinoma

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7485418 Aberrantly methylated genes in pancreatic cancer
7354725 Kinase peptides and antibodies

ANGPT2 results (if any) from reagent suppliers

Google CSE Logo
Ang-2 (F-18) Antibody sc-7017
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ANGPT2, 285, 8p23.1, NM_001147 ...
http://www.scbt.com/datasheet-7017-ang-2-f-18-antibody.html...

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Antibodies to Vessel Growth Regulators
A0851, Anti-Angiopoietin-2 antibody produced in goat, (polyclonal), affinity isolated antibody, human ... ANGPT2(285), human, ELISA (i), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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03-11-08HUPO.pdf
M-CSF |214pgiml), ANGPT2, IGF1R,. MBP, MMP8 (Ungimi). Note: About 2-fold increase of pro- tein identification by IgY-12 and. Plasma-SuperMix combination
...
http://www.genwaybio.com/images/gw_static/gw_products/gw_pro...

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Further Development of IgY-Immunoaffinity Fractionation – SuperMix ...
M-CSF (214pg/ml), ANGPT2, IGF1R,. MBP, MMP8 (11ng/ml). Note: About 2-fold increase of pro- tein identification by IgY-12 and. Plasma-SuperMix combination
...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General_...

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Akt Pathway Products
Extracellular Growth Factors/Cytokines. Gene Symbol. ANGPT1 · FGF8 · LHB · ANG1 · FGF9 · NTF5 · ANGPT2 · FGF10 · PDGFA · ANGPT4 · FGF16 · PDGFB ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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Cloning - United States Biological - Products
A2293-10B, Angiopoietin 2 (ANGPT2, AGPT2, Ang2) Primer P... A2293-01C, Angiopoietin-1 (ANGPT1, AGP1, AGPT, Ang1, ANG... A4775-50P, Axl, Human, ...
http://www.usbio.net/displayPage.php?Category=Cloning...

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JAK-STAT Signaling Pathway
EPHB4 · IL13RA (CD213A1), TYRO3 · ERBB2 (Her2), INSR (CD220). ERBB4 (Her4), INSRR. Cytokine Proteins. Gene Symbol. ANGPT1 · FGF1 · IL5 · ANGPT2 · FGF2 · IL6
...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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