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GPER
| Symbol: | GPER | | Name(s): | G protein-coupled estrogen receptor 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPR30, LERGU, LERGU2, LyGPR, MGC99678 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17878253 |
a relationship between GPR30 expression and age may underlie the observed pubertal decline in the GPR30 level |
| 17638621 |
GPR30 expression is downregulated in infiltrating ductal carcinoma of the breast; GPR30 is preferentially co-expressed with ER and/or PR but is lowly expressed in HER-2/neu(+) tumors |
| 11897506 |
estrogen transactivates the epidermal growth factor receptor (EGFR) to MAP K signaling axis via GPR30;implications for breast cancer biology |
| 12446589 |
results suggest that progestin-induced ERK inactivation is mediated through G protein-coupled receptor 30 |
| 15705806 |
GPR30 is localized to the endoplasmic reticulum where it specifically binds estrogen and estrogen derivatives; GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology |
| 15539556 |
GPR30, an orphan receptor unrelated to nuclear estrogen receptors, has all the binding and signaling characteristics of a membrane estrogen receptor |
| 12193550 |
orphan receptor GPR30 is important for the inhibitory effect of progestin on mammary gland growth |
| 15090535 |
The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol, genistrin and quercetin in breast cancer cells. |
Recent Publications on GPER: |  |
A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia/reperfusion injury.
OBJECTIVE: Several studies have recently demonstrated that G protein... | 3rd November, 2009
| University of California Los Angeles.
| Am J Physiol Heart Circ Physiol. 2009 Oct 30.
DOI Direct Link |
Non-genomic regulation of vascular cell function and growth by estrogen.
Estrogens exert rapid, non-genomic effects, which are mediated by plasma... | 29th October, 2009
| Departement fur Innere Medizin, Klinik und Poliklinik fur Innere Medizin,
| Mol Cell Endocrinol. 2009 Sep 24;308(1-2):9-16. Epub 2009 Mar 25.
DOI Direct Link |
Mechanisms of estrogen signaling and gene expression via GPR30.
The effects of estrogen are widespread throughout the body. Although the... | 29th October, 2009
| Department of Cell Biology & Physiology and Cancer Research and Treatment
| Mol Cell Endocrinol. 2009 Sep 24;308(1-2):32-8. Epub 2009 Apr 15.
DOI Direct Link |
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival.
OBJECTIVE: We showed that 17beta-estradiol (E(2)) favors pancreatic... | 24th October, 2009
| Department of Medicine, Division of Endocrinology, Metabolism and
| Diabetes. 2009 Oct;58(10):2292-302. Epub 2009 Jul 8.
DOI Direct Link |
17Beta-estradiol at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells.
The aim of this study was to identify differential responses to low... | 23rd October, 2009
| Department of Urology, Northwestern University Feinberg School of
| Endocrinology. 2009 Oct;150(10):4594-605. Epub 2009 Jul 16.
DOI Direct Link |
→View more research publications. |
GPER results (if any) from reagent suppliers | 
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GPER - R&D Systems
GPER. Products By Product Type. All Products for this Molecule · Antibodies · Legal; |; Sitemap. United States (change country); |; (800) 343-7475 ...
http://www.rndsystems.com/molecule_detail.aspx?m=4284...
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GPR30 (K-19)-R Antibody sc-48524-R
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GPER, 2852, 7p22.3, NM_001039966, ...
http://www.scbt.com/datasheet-48524-gpr30-k-19-antibody.html...
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June 09 NPR non-priced.indd
GPER. Human. Goat IgG. AF5534. 100 µg. HAX-1. Human. Goat IgG. AF5458. 100 µg. HIC5/TGFB1I1. Human. Goat IgG. AF5626. 100 µg. HMGB3. Human/Mouse. Goat IgG ...
http://www.rndsystems.com/DAM_public/6399.pdf...
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GPR30 (K-19)-R Antibody sc-48524-R
Humain, GPER, 2852, 7p22.3, NM_001039966, NM_001505 · Q99527 · 601805. Souris, Gper, 76854, 5 G2, Q8BMP4, Non disponible ...
http://www.scbt.com/fr/datasheet-48524-gpr30-k-19-antibody.h...
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E2758 β-Estradiol powder, cell culture tested
ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866). rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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GPR30 (K-19)-R Antibody sc-48524-R
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, GPER, 2852, 7p22.3, NM_001039966, ...
http://www.scbt.com/ja/datasheet-48524-gpr30-k-19-antibody.h...
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E1024 Estradiol meets USP testing specifications
ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866). rat ... Afp( 24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=E102...
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