Thursday November 26 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

GRIA3


Suggest Content
Advertise Here
Gene DB Home
Symbol:GRIA3
Name(s):glutamate receptor, ionotrophic, AMPA 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:GLUR-C, GLUR-K3, GLUR3, GLURC, MRX94
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18163426 Observational study of gene-disease association. (HuGE Navigator)
17989220 study provides the genetic and functional evidence that mutant iGluR3 with altered kinetic properties is associated with moderate cognitive impairment in humans
17202328 cleavage and release to the extracellular milieu of the GluR3B peptide may in principle increase its antigenicity
15144856 This study investigated whether the AMPA receptor subunit content (GluR1, GluR2, GluR2/3) within "vulnerable" vs. "resistant" sectors of the hippocampus is quantitatively altered with increasing Alzheimer Disease neuropathology
15145077 cell loss and up-regulation of glutamate receptor subunits appear early in temporal lobe epilepsy and contribute to the synaptic plasticity that may facilitate the subsequent sprouting of mossy fiber collaterals
12125045 Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.
12682273 T lymphocytes from normal individuals, an alloprimed human T cell clone, and human T leukemia (Jurkat) cells all express high levels of GluR3, identical in sequence with brain GluR3.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDGlutamate receptor, ionotropic, AMPA 3Yamaguchi sarcoma viral oncogene homolog isoform A--Pubmed
HPRDGlutamate receptor, ionotropic, AMPA 3protein phosphatase 1G--Pubmed
HPRDglutamate receptor 3 isoform flop precursorLyn--Pubmed
HPRDglutamate receptor 3 isoform flop precursorPP2C gamma--Pubmed

Recent Publications on GRIA3:

Pubmed Logo
Pharmacogenetics studies in STAR*D: strengths, limitations, and results.
Several lines of evidence support an important genetic contribution to the...
3rd November, 2009
Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Psychiatr Serv. 2009 Nov;60(11):1446-57.
DOI Direct Link
Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.
OBJECTIVES: Suicidal ideation is an uncommon but worrisome symptom than...
10th October, 2009
Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Pharmacogenet Genomics. 2009 Sep;19(9):666-74.
DOI Direct Link
Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.
BACKGROUND: Interferon beta is 1 of 2 first-line treatments for...
21st August, 2009
Centre d'Esclerosi Multiple de Catalunya, Unitat de Neuroimmunologia Arch Neurol. 2009 Aug;66(8):972-8.
DOI Direct Link
Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.
Sexual dysfunction is a major contributor to treatment discontinuation and...
4th August, 2009
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. Neuropsychopharmacology. 2009 Jun;34(7):1819-28. Epub 2009 Mar 18.
DOI Direct Link
Aberrant GRIA3 transcripts with multi-exon duplications in a family with X-linked mental retardation.
Investigation of chromosomal rearrangements in patients with mental...
31st July, 2009
Nancy Universite, EA 4002, Laboratoire de Genetique, Centre Hospitalier Am J Med Genet A. 2009 Jun;149A(6):1280-9.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

GRIA3 results (if any) from reagent suppliers

Google CSE Logo
GluR-3 (N-19) Antibody sc-7613
Human, GRIA3, 2892, Xq25, NM_000828, NM_007325, NM_181894 · P42263 · 305915. Mouse, Gria3, 53623, X A3.3, Q9Z2W9, N/A. Ordering Information ...
http://www.scbt.com/datasheet-7613-glur-3-n-19-antibody.html...

Thumbshot
Ionotropic Glutamate receptor 2 antibody (ab20673) | Abcam
These channels are assembled from 4 related subunits, GLURA (GRIA1), GLURB ( GRIA2), GLURC (GRIA3), GLURD (GRIA4), with the GLURB subunit rendering the ...
http://www.abcam.com/Ionotropic-Glutamate-receptor-2-antibod...

Thumbshot
p-GluR-2/3 (Ser 880/Ser 891) Antibody sc-101689
Mouse, Gria3, 53623, X A3.3, Q9Z2W9, N/A. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. p-GluR-2/3 (Ser 880/Ser 891) ...
http://www.scbt.com/datasheet-101689-p-glur-2-3-ser-880-ser-...

Thumbshot
N183 NBQX disodium salt hydrate ≥98% (HPLC), solid
Gene Information, human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901) ...
https://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=N18...

Thumbshot
C9847 Cyclothiazide
CA1(759), CA4(762), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893). rat ... Gria1(50592). storage temp. 2-8°C. Safety ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

Thumbshot
G119 GYKI 52466 hydrochloride solid
ethanol: 0.4 mg/mL. 0.1 M HCl: 0.68 mg/mL. methanol: 1 mg/mL. H2O: >10 mg/mL. Gene Information, human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

Thumbshot
C239 CNQX disodium salt hydrate ≥98% (HPLC), solid
H2O: >5 mg/mL. Gene Information, human ... ADORA1(134), ADORA2A(135), ADORA2B( 136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

Thumbshot

Search Bioportfolio and other Life Science Sites for GRIA3, or search for GRIA3 on BioPortfolio's antibody search engine.
This page has been viewed 320 times
Recent Search Terms used to find this page:
mouse glutamate receptor ionotropic AMPA 3 alpha | GRIA genecard | AMPA sexual dysfunction | AMPA sexual dysfunction | gria3 schizophrenia | grik2 gria3 association | gria 3 | AMPA receptors on lymphocytes | gabra2 kinetics | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.