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DCPS
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15769464 |
crystal structures of DcpS in ligand-free form and in a complex with m7GDP |
| 14523240 |
m7GDP breakdown by DcpS should prevent misincorporation of methylated nucleotides in nucleic acids and could generate a unique indicator allowing the cell to monitor mRNA decay. |
| 16140270 |
Furthermore, we show that a novel human histidine triad protein DCS-1, which is expressed together with NR1 in many tissues, can significantly reduce menadione-induced cytotoxicity in these cells |
| 12198172 |
The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. |
| 15068804 |
Structural and biochemical analysis suggests an autoregulatory mechanism whereby premature decapping mRNA is prevented by blocking the conformational changes that are required to form a closed productive active site capable of cap hydrolysis. |
DCPS results (if any) from reagent suppliers | 
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DcpS Antibody / DcpS Antibodies
DcpS Antibody / DcpS Antibodies. ... DcpS specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-dcps.html...
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References for ProtoArrayо protein microarrays
J Immunol Methods (available online). 5. Singh, J. et al. (2008) DcpS as a therapeutic target for spinal muscular atrophy. ACS Chem Biol 3:711–722. ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/protei...
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DcpS (E-20) Antibody sc-34352
DcpS shRNA (h) Lentiviral Particles, sc-44389-V, 200 µl ... DcpS (E-20): sc- 34352. Western blot analysis of DcpS expression in non-transfected: sc-117752
...
http://www.scbt.com/datasheet-34352-dcps-e-20-antibody.html...
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Repligen Corporation
22 Oct 2009 ... DcpS as a Therapeutic Target for Spinal Muscular Atrophy. ACS Chem Biol. 2008 Nov 21;3(11):711-22.Jasbir Singh, Michael Salcius, ...
http://www.repligen.com/news.php?page_id=29&news_id=108...
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DcpS (H4-32) Antibody sc-130451
DcpS (H4-32): sc-130451. Immunofluorescence staining of methanol-fixed HeLa cells ... Western blot analysis of DcpS expression in HeLa whole cell lysate.
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http://www.scbt.com/datasheet-130451-dcps-h4-32-antibody.htm...
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In vivo testing of D157495, a novel quinazoline compound, for the ...
target, DcpS, whose inhibition results in increasing SMN transcripts and protein both in vitro and in vivo. We have tested the ability of D157495 to enhance ...
http://www.repligen.com/uploads/Didonato_SMA_mouse_model.pdf...
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DcpS siRNA (m) sc-44390
Click here for details. suitable control antibody: DcpS (E-20): sc-34352; sqRT- PCR Primer also available: DcpS (m)-PR: sc-44390-PR, 20 µl ...
http://www.scbt.com/datasheet-44390-dcps-sirna-m.html...
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