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GRIN2A


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Symbol:GRIN2A
Name(s):glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Type:protein-coding
Organism:Homo sapiens
Synonyms:NMDAR2A, NR2A
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12082569 Observational study of gene-disease association. (HuGE Navigator)
12724619 Observational study of gene-disease association. (HuGE Navigator)
15742215 Observational study of gene-disease association. (HuGE Navigator)
15774266 Observational study of gene-disease association. (HuGE Navigator)
16266783 Observational study of gene-disease association. (HuGE Navigator)
16476413 Observational study of gene-disease association. (HuGE Navigator)
17011703 Observational study of gene-disease association. (HuGE Navigator)
17569088 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17942280 laser capture microdissection combined with quantitative PCR was used to examine the expression of AMPA (GRIA1-4) and NMDA (GRIN1, 2A and 2B) subunit mRNA levels in Layer II/III and Layer V pyramidal cells in the DLPFC.
18178157 The results of the present study, thus, suggest that blockage of NMDA receptors including the NR2A subunit suppresses MKN45 cell proliferation due to cell cycle arrest at the G(1) phase.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDactinin, alpha 1N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed
HPRDactinin, alpha 1N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed
HPRDSynapse associated protein 97N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed
HPRDdiscs, large homolog 1N-methyl D-aspartate receptor subunit 2A--Pubmed
HPRDChannel associated protein of synapse 110N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed
HPRDchapsyn-110N-methyl D-aspartate receptor subunit 2A--Pubmed
HPRDSynapse associated protein 102N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed
HPRDsynapse-associated protein 102N-methyl D-aspartate receptor subunit 2A--Pubmed
HPRDpostsynaptic density protein 95N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed
HPRDpostsynaptic density protein 95N-methyl-D-aspartate receptor subunit 2A precursor--Pubmed

Recent Publications on GRIN2A:

Pubmed Logo
Primate home range and GRIN2A, a receptor gene involved in neuronal plasticity: implications for the evolution of spatial memory.
N-methyl-D-aspartate (NMDA) glutamate receptors play crucial roles in...
12th September, 2009
Department of Biological Sciences and University Scholars Programme, Genes Brain Behav. 2009 Jun;8(4):435-41. Epub 2009 Feb 11.
DOI Direct Link
Microarray analysis of gene expression profile by treatment of Cinnamomi Ramulus in lipopolysaccharide-stimulated BV-2 cells.
It has been reported that components of Cinnamomi Ramulus (CR) demonstrate...
3rd July, 2009
Department of Applied Eastern Medicine, Graduate School, Kyung Hee Gene. 2009 Aug 15;443(1-2):83-90. Epub 2009 May 5.
DOI Direct Link
Heroin addiction in African Americans: a hypothesis-driven association study.
Heroin addiction is a chronic complex disease with a substantial genetic...
9th June, 2009
The Laboratory of the Biology of Addictive Diseases, The Rockefeller Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
DOI Direct Link
Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.
BACKGROUND: We reviewed systematically the results of genetic studies...
22nd May, 2009
Research unit Cognitive dysfunctions in psychiatric diseases, Razi J Psychiatry Neurosci. 2009 Mar;34(2):88-101.
Genome-wide association study of smoking initiation and current smoking.
For the identification of genes associated with smoking initiation and...
10th April, 2009
Department of Biological Psychology, Center for Neurogenomic and Cognitive Am J Hum Genet. 2009 Mar;84(3):367-79. Epub 2009 Mar 5.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
An Investigation of the Antidepressant Effects of a Low-Trapping Mixed NR2A/2B Antagonist in Treatment-Resistant Major Depression

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

GRIN2A results (if any) from reagent suppliers

Google CSE Logo
Antibodies to Glutamate Receptors
Grin2a(14811), rat, human, mouse, IP, WB, pricing. M265, Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit, affinity isolated antibody ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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G9038 Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in ...
application(s), immunoblotting: 1:3000 using extract of rat brain synaptosomal fraction. microarray: suitable. Gene Information, human ... GRIN2A(2903) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Antibodies to Neurotransmitter Receptors
affinity isolated antibody, human ... GRIN2A(2903) mouse ... Grin2a(14811) rat . .. Grin2a(24409), rat, human, mouse, ARR, WB, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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NMDAε1 (H-54) Antibody sc-9056
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GRIN2A, 2903, 16p13.2, NM_000833 ...
http://www.scbt.com/datasheet-9056-nmdaepsilon1-h-54-antibod...

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NMDA receptor 2B antibody, NMDA receptor 2B Antibody, Rabbit ...
NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), ...
http://www.genwaybio.com/product_info.php?products_id=196191...

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M3262 N-Methyl-D-aspartic acid NMDA ≥98% (TLC), solid
GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907) . rat ... Gria1(50592), Grik1(29559), Grin2a(24409) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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GRIN1 antibody, NMDA, NR1, N1 Antibody, Rabbit Polyclonal Antibody
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); ...
http://www.genwaybio.com/product_info.php?products_id=73746...

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