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GRIN2B


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Symbol:GRIN2B
Name(s):glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC142178, MGC142180, NMDAR2B, NR2B, hNR3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18303265 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
11317224 Observational study of gene-disease association. (HuGE Navigator)
11807413 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
11844890 Observational study of gene-disease association. (HuGE Navigator)
11956967 Observational study of gene-disease association. (HuGE Navigator)
11979061 Observational study of gene-disease association. (HuGE Navigator)
12082569 Observational study of gene-disease association. (HuGE Navigator)
12476325 Observational study of gene-disease association. (HuGE Navigator)
12556902 Observational study of gene-disease association. (HuGE Navigator)
12824739 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAlpha actinin 2N-methyl-D-aspartate receptor subunit 2B precursor--Pubmed
HPRDactinin, alpha 2N-methyl D-aspartate receptor subunit 2B--Pubmed
HPRDCaMK II alpha subunitN-methyl-D-aspartate receptor subunit 2B precursor--Pubmed
HPRDcalcium/calmodulin-dependent protein kinase IIA isoform 1N-methyl D-aspartate receptor subunit 2B--Pubmed
HPRDChannel associated protein of synapse 110N-methyl-D-aspartate receptor subunit 2B precursor--Pubmed
HPRDchapsyn-110N-methyl D-aspartate receptor subunit 2B--Pubmed
HPRDSynapse associated protein 102N-methyl-D-aspartate receptor subunit 2B precursor--Pubmed
HPRDsynapse-associated protein 102N-methyl D-aspartate receptor subunit 2B--Pubmed
HPRDpostsynaptic density protein 95N-methyl-D-aspartate receptor subunit 2B precursor--Pubmed
HPRDpostsynaptic density protein 95N-methyl-D-aspartate receptor subunit 2B precursor--Pubmed

Recent Publications on GRIN2B:

Pubmed Logo
No association of three GRIN2B polymorphisms with lithium response in bipolar patients.
We investigated three polymorphisms in the NMDA receptor 2B subunit gene...
17th July, 2009
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Pharmacol Rep. 2009 May-Jun;61(3):448-52.
Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexia.
A multi-marker haplotype within GRIN2B, a gene coding for a subunit of the...
11th July, 2009
Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 9.
DOI Direct Link
Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease.
We aimed to assess whether allelic variants of dopamine receptor,...
30th June, 2009
Department of Neurology, Inje University Ilsan Paik Hospital, Goyang, Mov Disord. 2009 Sep 15;24(12):1803-10.
DOI Direct Link
Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.
In this preliminary study, 16 psychotropic-naive pediatric patients with...
6th June, 2009
Program in Genetics and Genomic Biology, Hospital for Sick Children, Psychiatry Res. 2009 May 15;172(2):136-9. Epub 2009 Mar 25.
DOI Direct Link
Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population.
N-methyl-d-aspartate (NMDA) receptor plays a crucial role in learning,...
21st April, 2009
Department of Neurology, Xuan Wu Hospital of the Capital Medical Neurosci Lett. 2009 Feb 6;450(3):356-60. Epub 2008 Oct 25.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
The Effects of an NR2B NMDA Antagonist, CP-101,606, in Patients With Parkinson's Disease

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7425614 Neuroprotective therapeutics preventing ERK/MAPK activation through the NMDA receptor
7368264 SLC1A1 marker for anxiety disorder
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

GRIN2B results (if any) from reagent suppliers

Google CSE Logo
Antibodies to Glutamate Receptors
human ... GRIN2B(2904) mouse ... Grin2b(14812), rat, mouse, human, ELISA (i), IHC (f), IP, WB, pricing ... GRIN2B(2904), mouse, human, chicken, Xenopus, rat
...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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NMDA receptor 2B antibody, NMDA receptor 2B Antibody, Rabbit ...
NMDA receptor 2B antibody; NMDA receptor 2B; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B Glutamate receptor ionotropic NMDA2B GRIN2B hNR3 N METHYL
...
http://www.genwaybio.com/product_info.php?products_id=196191...

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M265 Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in ...
immunoprecipitation: 3 μL using 200 μg of rat brain. indirect ELISA: suitable. Gene Information, human ... GRIN2B(2904). rat ... Grin2b(24410) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=M265...

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p-NMDAε2 (Tyr 1336) Antibody sc-135703
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GRIN2B, 2904, 12p13.1, Q13224 ...
http://www.scbt.com/datasheet-135703-p-nmdaepsilon2-tyr-1336...

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M2442 Anti-phospho-N-Methyl D-Aspartate NR2B Subunit (pTyr1472 ...
Gene Information, human ... GRIN2B(2904). rat ... Grin2b(24410). mouse ... Grin2b(14812). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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GRIN1 antibody, NMDA, NR1, N1 Antibody, Rabbit Polyclonal Antibody
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); ...
http://www.genwaybio.com/product_info.php?products_id=73746...

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NMDAR2B antibody [NR2B] (ab28373) | Abcam
GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro- pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by ...
http://www.abcam.com/NMDAR2B-antibody-NR2B-ab28373.html...

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