BioPortfolio - CD274 - CD274 molecule

CD274

Symbol:

CD274

Name(s):

CD274 molecule

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1, PDCD1LG1, PDL1

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

18322304

Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)

18301333

possible functional relationship between the enhanced incidence of precursor plasmacytoid dendritic cells, their comparatively high relative expression of the coinhibitory molecule PD-L1

14617032

Observational study of gene-disease association. (HuGE Navigator)

17203303

Observational study of gene-disease association. (HuGE Navigator)

17597384

Observational study of gene-disease association. (HuGE Navigator)

17597384

PD-L1 polymorphisms are not associated with susceptibility to rheumatoid arthritis, but 6777 G is associated with the prevalence of rheumatoid nodule in Taiwanese patients.

17942371

results suggest that the PD-1/PD-L1 pathway may play a regulatory role in memory T cell subsets in addition to its association with T-cell exhaustion

17938288

PD-L1-deficient transgenic mice reconstituted with bone marrow from wild-type mice remain susceptible to severe myocarditis, demonstrating the protective effect of PD-L1 on non-bone marrow-derived cells.

17562772

Induction of cells of the T regulatory (Treg) phenotype by B7-H1 may play an important role in the T-cell suppression associated with Helicobacter pylori infection, as well as other infections that result in an up-regulation of B7-H1.

17363736

Inhibition of the MyD88 and TRAF6 adaptor proteins of the TLR pathway blocked not only B7-H1 expression induced by TLR ligands but also that mediated by IFN-gamma

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