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GRP


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Symbol:GRP
Name(s):gastrin-releasing peptide
Type:protein-coding
Organism:Homo sapiens
Synonyms:BN, GRP-10, preproGRP, proGRP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15750618 GRP is a new angiogenic peptide and that its inhibition offers an attractive tool to reduce tumor burden.
12474049 mRNA transcripts are expressed in tumor cells of patients with small cell lung cancer
13679857 Mitogenic effects of GRP in head and neck squamous cells are mediated by activation of the epidermal growth factor receptor.
16641105 results show that TACE undergoes phosphorylation that regulates release of amphiregulin upon GRP treatment; a signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, translocation & phosphorylation is suggested
15899028 BN/GRP and substance P are involved together with cytokines in the neuroimmunomodulation that occurs in the arthritic joint.
16920698 GRP upregulation of ICAM-1 via FAK promotes tumor cell motility and attachment to the extracellular matrix.
14764456 GRP is over-expressed in esophageal squamous cell carcinoma, and its over-expression may play a role in such carcinoma development and growth
15849504 An increase in GRP binding capacity, as a result of GRP-R overexpression, down-regulates PTEN expression. Inhibition of the tumor suppressor gene PTEN may be an important regulatory mechanism involved in GRP-induced cell proliferation in neuroblastomas.
15638385 Measuring serum levels in lung cancer patients may be useful in drug therapy monitoring.
11960700 GRP/GRP-R play a transient and non-critical role in intestinal development

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDDipeptidyl peptidase IVgastrin-releasing peptide isoform 1 preproprotein--Pubmed
HPRDdipeptidylpeptidase IVGastrin releasing polypeptide--Pubmed
HPRDgastrin-releasing peptide isoform 1 preproproteingastrin-releasing peptide receptor--Pubmed
HPRDgastrin-releasing peptide isoform 1 preproproteingastrin-releasing peptide receptor--Pubmed

Recent Publications on GRP:

Pubmed Logo
Androgen-regulated gastrin-releasing peptide receptor expression in androgen-dependent human prostate tumour xenografts.
Human prostate cancer (PC) overexpresses the gastrin-releasing peptide...
31st October, 2009
Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. Int J Cancer. 2009 Oct 28.
DOI Direct Link
High-Voltage Electron Microscopy Reveals Direct Synaptic Inputs from a Spinal Gastrin-Releasing Peptide System to Neurons of the Spinal Nucleus of Bulbocavernosus.
The spinal nucleus of bulbocavernosus (SNB) is a sexually dimorphic motor...
30th October, 2009
Ushimado Marine Laboratory (H.S.), Graduate School of Natural Science and Endocrinology. 2009 Oct 28.
DOI Direct Link
Activation and clinical significance of the unfolded protein response in breast cancer.
Introduction:The tumour microenvironment is hypoglycaemic, hypoxic and...
29th October, 2009
Academic Unit of Surgical Oncology, Department of Oncology, School of Br J Cancer. 2009 Oct 27.
DOI Direct Link
Plant polyphenol intake alters gene expression in canine leukocytes.
BACKGROUND/AIMS: Polyphenol compounds may explain most of the...
22nd October, 2009
Affinity Petcare, Research and Development Department, Barcelona, Spain. J Nutrigenet Nutrigenomics. 2009;2(1):43-52. Epub 2009 Feb 6.
DOI Direct Link
Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment.
Methamphetamine (MA) is an addictive psycho-stimulant and the illicit use...
15th October, 2009
Division of Medical Physiology, University of Stellenbosch, Tygerberg, Metab Brain Dis. 2009 Oct 14.
DOI Direct Link

View more research publications.

Press Releases on GRP:

BioPortfolio Logo
Raptor Pharmaceuticals Appoints Dr. Patrice P. Rioux as Chief Medical Officer 13th April, 2009

NOVATO, California, April 13 /PRNewswire/ -- Raptor Pharmaceuticals Corp. ("Raptor" or the "Company") (OTC Bulletin Board: RPTP) today announced the appointment of Patrice P.

BioNews Results for GRP

: RSS Logo
BioPortfolio Logo
DIARY - US Company Meetings for Thursday Nov 12, 2009
Reuters:  Nov 12 2009 10:05AM Matching: grp
Rohto Pharmaceutical 1H Grp Net Pft Y3.10B Vs Y2.75B Pft Yr Earlier
Wall Street Journal Online:  Nov 10 2009 4:31AM Matching: grp
Reichhold Opens New Manufacturing Plant in Pune, India
Chemie.de:  Nov 6 2009 1:08PM Matching: grp
Rhaglen brechu rhag ffliw moch yn cychwyn
Welsh Assembly Government:  Nov 4 2009 7:38AM Matching: grp
Current Regulatory Environment in Latin America Conference by Drug Information Assn & AMEIFAC; Nov 18-20, 2009
Pharma Live:  Oct 20 2009 1:15AM Matching: grp
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Safety and Immunogenicity Study of Group B Meningococcal Vaccine to Prevent Meningitis.

Patents:

Patents logo
US Patent No.Title
7577687 Systems and methods for synchronizing databases
7588880 Incorporable photoinitiator
7588906 Hydrogels for biomolecule analysis and corresponding method to analyze biomolecules
7589111 C10 cyclopentyl ester substituted taxanes
7589174 GRP94-based compositions and methods of use thereof

View more patents.

GRP results (if any) from reagent suppliers

Google CSE Logo
GRP 78 (N-20) Antibody sc-1050
See how others have used GRP 78 (N-20): sc-1050 antibody and or GRP 78 (N-20) ... Western blot analysis of GRP 78 expression in Jurkat whole cell lysate. ...
http://www.scbt.com/datasheet-1050-grp-78-n-20-antibody.html...

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Anti-Gastrin-Releasing Peptide Receptor Polyclonal Antibody
The PA3-304 immunogen is a synthetic peptide corresponding to residues T(364) N P S V A T F S L I N G N I C H E R Y V(384) of human GRP-R receptor protein.
...
http://www.bioreagents.com/products/productDetails/productDe...

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GRP 94 (SPM249) Antibody sc-56399
GRP 94 shRNA (h) Lentiviral Particles, sc-35523-V, 200 µl ... GRP 94 (SPM249): sc-56399. Western blot analysis of GRP 94 expression in NIH/3T3 (A), ...
http://www.scbt.com/datasheet-56399-grp-94-spm249-antibody.h...

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Gastrin Releasing Peptide (GRP) and Its C-Terminal Bioactive Fragments
Phoenix Pharmaceuticals offers GRP peptides, antibodies, and immunoassay kits.
http://www.phoenixpeptide.com/catalog/pnxfoget.php?id=pnxnew...

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GRP 94 (H-212) Antibody sc-11402
See how others have used GRP 94 (H-212): sc-11402 antibody and or GRP 94 ... Western blot analysis of GRP 94 expression in NIH/3T3 whole cell lysate. ...
http://www.scbt.com/datasheet-11402-grp-94-h-212-antibody.ht...

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GRP peptide, Gastrin Releasing Peptide Porcine peptide
Buy quality GRP peptide (n/a), GRP, Gastrin Releasing Peptide Porcine peptide, ( n/an/a). GRP; Proventricular peptide; Gastrin-releasing peptide (GRP) ...
http://www.genwaybio.com/product_info.php?products_id=83233...

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GRP 75 (H-155) Antibody sc-13967
See how others have used GRP 75 (H-155): sc-13967 antibody and or GRP 75 (H-155) ... Western blot analysis of GRP 75 expression in HeLa (A) and NIH/3T3 (B) ...
http://www.scbt.com/datasheet-13967-grp-75-h-155-antibody.ht...

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