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GSK3B

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Symbol:	GSK3B
Name(s):	glycogen synthase kinase 3 beta
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	-
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18156211	sFRP-1 can interact with Wnt receptors Frizzled 4 and 7 on endothelial cells to transduce downstream to cellular machineries requiring Rac-1 activity in cooperation with GSK-3beta
18055457	GSK3beta interacts with and phosphorylates the spindle-associated protein Astrin, resulting in targeting Astrin to the spindle microtubules and kinetochores.
17991738	GSK3B protects melanoma cells from the apoptotic effects sorafenib, providing a survival signal that minimizes cellular injury.
14729229	Observational study of gene-disease association. (HuGE Navigator)
15179015	Observational study of gene-disease association. (HuGE Navigator)
15351432	Observational study of gene-disease association. (HuGE Navigator)
15719395	Observational study of gene-disease association. (HuGE Navigator)
16289845	Observational study of gene-disease association. (HuGE Navigator)
16315267	Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16397405	Observational study of gene-disease association. (HuGE Navigator)
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	serine/threonine protein kinase	glycogen synthase kinase 3 beta	AKT1 interacts with and phosphorylates GSK3B. This interaction was modelled on a demonstrated interaction between human AKT1 and GSK3B from an unspecified species.	-	Pubmed
HPRD	Human rac protein kinase beta mRNA, and translated products	glycogen synthase kinase 3 beta	-	-	Pubmed
HPRD	Human rac protein kinase beta mRNA, and translated products	glycogen synthase kinase 3 beta	-	-	Pubmed
BIND	B-cell CLL/lymphoma 3	glycogen synthase kinase 3 beta	GSK3-beta interacts with and phosphorylates BCL-3.	-	Pubmed
BIND	catenin, beta 1, 88kDa	glycogen synthase kinase 3 beta	GSK3B (GSK3-Beta) interacts with and phosphorylates CTNNB1 (Beta-catenin).	-	Pubmed
HPRD	Dishevelled 1	glycogen synthase kinase 3 beta	-	-	Pubmed
HPRD	dishevelled 1	Glycogen synthase kinase 3 beta	-	-	Pubmed
HPRD	Glycogen synthase kinase 3 beta	tumor protein p53	-	-	Pubmed
HPRD	Glycogen synthase kinase 3 beta	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	-	Pubmed
HPRD	Glycogen synthase kinase 3 beta	integrin-linked kinase	-	-	Pubmed

Recent Publications on GSK3B:
Expression QTL and regulatory network analysis of microtubule-associated protein tau gene. Numerous studies have shown that the microtubule-associated protein tau...	13th October, 2009	Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong	Parkinsonism Relat Disord. 2009 Aug;15(7):525-31. Epub 2009 Feb 23. DOI Direct Link
Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways. Wnt-signal transduction is critical for development and tissue homeostasis...	6th October, 2009	[1] Division of Molecular Genetics, Netherlands Cancer Institute,	Oncogene. 2009 Oct 5. DOI Direct Link
Validating GSK3 as an in vivo target of lithium action. Lithium is widely used to treat bipolar disorder, but its mechanism of...	17th September, 2009	Department of Medicine, University of Pennsylvania School of Medicine,	Biochem Soc Trans. 2009 Oct;37(Pt 5):1133-8. DOI Direct Link
Knockout mice in understanding the mechanism of action of lithium. Lithium inhibits IMPase (inositol monophosphatase) activity, as well as...	17th September, 2009	Faculty of Health Sciences, Ben Gurion University of the Negev,	Biochem Soc Trans. 2009 Oct;37(Pt 5):1121-5. DOI Direct Link
Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment. Chondrosarcomas are notorious for their resistance to conventional...	12th September, 2009	Department of Pathology and Orthopedic Surgery, Leiden University Medical	Cancer Res. 2009 Aug 1;69(15):6216-22. Epub 2009 Jul 14. DOI Direct Link
→View more research publications.

Clinical Trials:
Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy

Patents:
US Patent No.	Title
6498176	3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
6929916	Protein fragment complementation assays for the detection of biological or drug interactions
6933299	Anilinoquinazolines as protein tyrosine kinase inhibitors
6994848	Lactobacillus paracasei strain GM-080 for treating allergy related diseases
7008953	3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
→View more patents.

GSK3B results (if any) from reagent suppliers

GSK3B Antibody Specific antibody for the gene product of GSK3B, the protein Glycogen synthase kinase 3 beta. Validated for specificity by gene-silencing with siRNA ... http://www.piercenet.com/products/Browse.cfm?fldID=4BB74BF3-...
GSK3B antibody, Glycogen synthase kinase-3 beta Antibody, Chicken ... Buy quality chicken GSK3B antibody (interacts with human mouse rat), anti-GSK3B, Glycogen synthase kinase-3 beta antibody, chicken igy polyclonal antibody, ... http://www.genwaybio.com/product_info.php?products_id=634...
Phospho-GSK3B-S21/29 Antibody Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B; ... #AP3111a) is used in Western blot to detect Phospho-GSK3B-S21/29 in mouse thymus tissue lysate. ... http://www.abgent.com/products/catalog_no/AP3111a_Phospho_GS...
GSK3B antibody, Rabbit anti GSK3b pS9 Antibody, Rabbit Polyclonal ... Buy quality rabbit GSK3B antibody (interacts with n/a), anti-GSK3B, ... Rabbit anti GSK3b pS9; GSK-3 beta; EC 2.7.11.26; Glycogen synthase kinase-3 beta, ... http://www.genwaybio.com/product_info.php?products_id=244379...
GSK3 beta (GSK3B) Antibody (N-term) Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein kinases ... http://www.abgent.com/products/catalog_no/AP8121a_GSK3_beta_...
Peptide-affinity Purified Polyclonal Antibody to GSK3b (Ab-216) This antibody was generated by immunizing rabbits with a synthetic non- phosphopeptide corresponding to human GSK3b around the phosphorylation site of ... http://www.imgenex.com/antibody_details.php?catalog=IMG-9058...
GSK3B Antibody (S21/29) Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B ... AP8121e) is used in Western blot to detect GSK3B in mouse thymus tissue lysate. ... http://www.abgent.com/products/catalog_no/AP8121e_GSK3B_Anti...

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GSK3B

Gene Information from Publications

Interacting gene products

Recent Publications on GSK3B:

Clinical Trials:

Patents:

GSK3B results (if any) from reagent suppliers