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GSK3B


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Gene DB Home
Symbol:GSK3B
Name(s):glycogen synthase kinase 3 beta
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18156211 sFRP-1 can interact with Wnt receptors Frizzled 4 and 7 on endothelial cells to transduce downstream to cellular machineries requiring Rac-1 activity in cooperation with GSK-3beta
18055457 GSK3beta interacts with and phosphorylates the spindle-associated protein Astrin, resulting in targeting Astrin to the spindle microtubules and kinetochores.
17991738 GSK3B protects melanoma cells from the apoptotic effects sorafenib, providing a survival signal that minimizes cellular injury.
14729229 Observational study of gene-disease association. (HuGE Navigator)
15179015 Observational study of gene-disease association. (HuGE Navigator)
15351432 Observational study of gene-disease association. (HuGE Navigator)
15719395 Observational study of gene-disease association. (HuGE Navigator)
16289845 Observational study of gene-disease association. (HuGE Navigator)
16315267 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16397405 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDserine/threonine protein kinaseglycogen synthase kinase 3 betaAKT1 interacts with and phosphorylates GSK3B. This interaction was modelled on a demonstrated interaction between human AKT1 and GSK3B from an unspecified species.-Pubmed
HPRDHuman rac protein kinase beta mRNA, and translated productsglycogen synthase kinase 3 beta--Pubmed
HPRDHuman rac protein kinase beta mRNA, and translated productsglycogen synthase kinase 3 beta--Pubmed
BINDB-cell CLL/lymphoma 3glycogen synthase kinase 3 betaGSK3-beta interacts with and phosphorylates BCL-3.-Pubmed
BINDcatenin, beta 1, 88kDaglycogen synthase kinase 3 betaGSK3B (GSK3-Beta) interacts with and phosphorylates CTNNB1 (Beta-catenin).-Pubmed
HPRDDishevelled 1glycogen synthase kinase 3 beta--Pubmed
HPRDdishevelled 1Glycogen synthase kinase 3 beta--Pubmed
HPRDGlycogen synthase kinase 3 betatumor protein p53--Pubmed
HPRDGlycogen synthase kinase 3 betanuclear factor of kappa light polypeptide gene enhancer in B-cells 1--Pubmed
HPRDGlycogen synthase kinase 3 betaintegrin-linked kinase--Pubmed

Recent Publications on GSK3B:

Pubmed Logo
Expression QTL and regulatory network analysis of microtubule-associated protein tau gene.
Numerous studies have shown that the microtubule-associated protein tau...
13th October, 2009
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong Parkinsonism Relat Disord. 2009 Aug;15(7):525-31. Epub 2009 Feb 23.
DOI Direct Link
Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
Wnt-signal transduction is critical for development and tissue homeostasis...
6th October, 2009
[1] Division of Molecular Genetics, Netherlands Cancer Institute, Oncogene. 2009 Oct 5.
DOI Direct Link
Validating GSK3 as an in vivo target of lithium action.
Lithium is widely used to treat bipolar disorder, but its mechanism of...
17th September, 2009
Department of Medicine, University of Pennsylvania School of Medicine, Biochem Soc Trans. 2009 Oct;37(Pt 5):1133-8.
DOI Direct Link
Knockout mice in understanding the mechanism of action of lithium.
Lithium inhibits IMPase (inositol monophosphatase) activity, as well as...
17th September, 2009
Faculty of Health Sciences, Ben Gurion University of the Negev, Biochem Soc Trans. 2009 Oct;37(Pt 5):1121-5.
DOI Direct Link
Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment.
Chondrosarcomas are notorious for their resistance to conventional...
12th September, 2009
Department of Pathology and Orthopedic Surgery, Leiden University Medical Cancer Res. 2009 Aug 1;69(15):6216-22. Epub 2009 Jul 14.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy

Patents:

Patents logo
US Patent No.Title
6620818 Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
6933299 Anilinoquinazolines as protein tyrosine kinase inhibitors
6994848 Lactobacillus paracasei strain GM-080 for treating allergy related diseases
7008953 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

GSK3B results (if any) from reagent suppliers

Google CSE Logo
GSK3B Antibody
Specific antibody for the gene product of GSK3B, the protein Glycogen synthase kinase 3 beta. Validated for specificity by gene-silencing with siRNA ...
http://www.piercenet.com/products/Browse.cfm?fldID=4BB74BF3-...

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GSK3B antibody, Rabbit anti GSK3b pS9 Antibody, Rabbit Polyclonal ...
Buy quality rabbit GSK3B antibody (interacts with n/a), anti-GSK3B, ... Rabbit anti GSK3b pS9; GSK-3 beta; EC 2.7.11.26; Glycogen synthase kinase-3 beta, ...
http://www.genwaybio.com/product_info.php?products_id=244379...

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Phospho-GSK3B-S21/29 Antibody
Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B; ... #AP3111a) is used in Western blot to detect Phospho-GSK3B-S21/29 in mouse thymus tissue lysate. ...
http://www.abgent.com/products/catalog_no/AP3111a_Phospho_GS...

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Anti-Glycogen Synthase Kinase-3b (GSK-3b) antibody produced in ...
ANTI-GLYCOGEN SYNTHASE KINASE-3β (GSK-3β),. Developed in Rabbit. Affinity Isolated Antibody. Product Number G7914. Product Description ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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GSK3 beta (GSK3B) Antibody (N-term)
Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B ... #AP8121a) is used in Western blot to detect GSK3B in 293 cell lysate. GSK3 beta (GSK3B) Antibody ...
http://www.abgent.com/products/catalog_no/AP8121a_GSK3_beta_...

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Peptide-affinity Purified Polyclonal Antibody to GSK3b (Ab-216)
GSK3b is a proline directed serine/threonine kinase, originally identified as a result of its role in glycogen metabolism regulation. ...
http://www.imgenex.com/antibody_details.php?catalog=IMG-9058...

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GSK3 beta (GSK3B) Antibody (C-term)
(RIGHT)Formalin-fixed and paraffin-embedded human testis tissue reacted with GSK3B Antibody (C-term) (Cat.#AP8121b), which was peroxidase-conjugated to the
...
http://www.abgent.com/products/catalog_no/AP8121b_GSK3_beta_...

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