Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18156211 |
sFRP-1 can interact with Wnt receptors Frizzled 4 and 7 on endothelial cells to transduce downstream to cellular machineries requiring Rac-1 activity in cooperation with GSK-3beta |
| 18055457 |
GSK3beta interacts with and phosphorylates the spindle-associated protein Astrin, resulting in targeting Astrin to the spindle microtubules and kinetochores. |
| 17991738 |
GSK3B protects melanoma cells from the apoptotic effects sorafenib, providing a survival signal that minimizes cellular injury. |
| 14729229 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15179015 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15351432 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15719395 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16289845 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16315267 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 16397405 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16428884 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16528748 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16787706 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 16861141 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17160944 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17233643 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17270183 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17357145 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17368486 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17628506 |
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17976739 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18195729 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17717075 |
GnRH treatment mediates the inactivation of glycogen synthase kinase-3, a protein serine/threonine kinase that regulates beta-catenin degradation within the Wnt signaling pathway |
| 17621269 |
Ajuba promoted GSK-3beta-mediated phosphorylation of beta-catenin by reinforcing the association between beta-catenin and GSK-3beta. |
| 17951252 |
modulation of phosphatidylinositol 3-kinase/Akt/GSK3beta signaling cascades can be beneficial for protecting or facilitating recovery from cellular LeTx intoxication in cells that depend on basal MEK1 activity for proliferation. |
| 18167338 |
Glycogen synthase kinase-3beta (GSK-3beta) phosphorylates Cdc25A to promote its proteolysis in early cell-cycle phases. |
| 17908237 |
This indicates that if the majority of tau is phosphorylated at S396/S404, in combination with increased GSK3beta activity, tau aggregation is favored. T |
| 17711861 |
a direct link between GSK-3beta and MLK3 activation in a neuronal cell death pathway and identify MLK3 as a direct downstream target of GSK-3beta. |
| 17486076 |
cyclin D2 expression in normal and malignant hematopoietic cells is regulated by ubiquitin/proteasome-dependent degradation triggered by Thr280 phosphorylation by GSK3beta or p38, which is induced by inhibition of the PI3K pathway |
| 17609434 |
GSK-3 is required for E2-induced ERalpha phosphorylation at Ser-118 and full transcriptional activity of the receptor upon E2 stimulation. |
| 17972518 |
Phosphorylated-GSK3beta-ser9 and EGFR are involved in the histogenesis of different lung carcinomas. |
| 17912008 |
glycogen synthase kinase-3beta (GSK-3beta) was found to regulate NF kappa B activation and the proliferation and survival of pancreatic cancer cells.[review] |
| 17671694 |
pGSK-3beta-ser-9 may confer the cisplatin resistance of ovarian carcinomas through the stabilization of p53 expression |
| 16951223 |
The GSK-3beta nuclear accumulation as a hallmark of poorly differentiated pancreatic adenocarcinoma, and provide new insight into the mechanism by which GSK-3beta regulates NF-kappaB activity in pancreatic cancer. |
| 17681942 |
analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity |
| 17697341 |
observations indicate a role for GSK-3 in accurate chromosome segregation |
| 17483602 |
GSK-3beta was dephosphosphorylated at Ser9 & its enzymatic activity increased in palmitate-treated human umbilical vein endothelial cells. GSK-3beta inhibitors & transduction with a catalytically inactive GSK-3beta protected the cells from apoptosis. |
| 17522055 |
3,3'-diindolylmethane -induced cell growth inhibition and apoptosis induction are partly mediated through the regulation of Akt/FOXO3a/GSK-3beta/beta-catenin/AR signaling |
| 17565981 |
GSK3beta facilitates the association of T4 and T4C3, and the presence of caspase-cleaved tau is necessary for the evolution of tau oligomers into Sarkosyl-insoluble inclusions even though it is not extensively phosphorylated |
| 17562708 |
phosphorylation sites in tau from Alzheimer brain show that casein kinase 1delta may have a role, together with glycogen synthase kinase-3beta, in the pathogenesis of Alzheimer disea |
| 17621172 |
Single nucleotide polymorphisms are not asociated with bipolar disorder. |
| 17016438 |
Hypersensitivity of medulloblastoma cells in anchorage-independence is linked to GSK-3beta activity. |
| 12663502 |
role in mouse hepatic carcinogenesis |
| 15132987 |
6-OHDA inhibited phosphorylation of GSK3beta at Ser9, & induced hyperphosphorylation of Tyr216 with little effect on expression. GSK3beta is a critical intermediate in pro-apoptotic signaling cascades that are associated with neurodegenerative diseases. |
| 12969793 |
Overexpression of phospho-GSK-3beta is associated with hepatocellular carcinoma |
| 16365045 |
a direct interaction between LRP6 and GSK3 results in an attenuation of GSK3 activity |
| 12048243 |
reacts with p53 protein after dna damage |
| 15379854 |
A portion of the p53 that is activated in senescent cells is modulated by its association with GSK3beta in the nucleus. |
| 16601113 |
GSK-3beta selectively regulates NFkappaB-mediated inflammatory gene expression of IL-1beta and TNF-alpha by controlling the flow of NFkappaB activity between transcription of inflammatory and survival genes |
| 17438332 |
antiapoptotic effect of GSK3beta in tumor necrosis factor-induced apoptosis is mediated by cytosolic, not nuclear, GSK3beta |
| 12829841 |
manipulation of GSK-3beta activity may be a mechanism by which HHV-8 latency-associated nuclear antigen (LANA) may modify transcriptional activity and contribute to the phenotype of HHV-8 primary effusion lymphoma. |
| 15020233 |
Glycogen synthase kinase-3beta is tyrosine-phosphorylated by mitogen-activated protein kinase kinase 1 in fibroblasts. |
| 16043125 |
Our findings demonstrate an unrecognized role of GSK3beta in tumor cell survival and proliferation other than its predicted role as a tumor suppressor. |
| 17098228 |
The current data suggest that, following exposure to zinc, the sequential activation of Akt and GSK-3beta plays an important role directing hippocampal neural precursor cell death. |
| 12778079 |
Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest and involve this enzyme in vitro. |
| 12387894 |
role in phosphorylating tau protein |
| 17046823 |
GSK-3beta but also DYRK1B modulates cyclin D1 subcellular localization by the phosphorylation of Thr(288). These results suggest that DIF-3 induces degradation of cyclin D1 through the GSK-3beta- and DYRK1B-mediated threonine phosphorylation in HeLa cells |
| 11903055 |
Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion. |
| 15631989 |
Data show that the activity of glycogen synthase kinase-3 (GSK-3) is necessary for the maintenance of the epithelial architecture, and that GSK-3 inhibition stimulates the transcription of Snail. |
| 16645641 |
findings show an increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2 and for GSK-3beta in the brains of Alzheimer disease patients |
| 16987514 |
These results indicate that the protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation induced by KCl and that GSK3 activity regulates SERCA2 levels. |
| 17050006 |
offer a new mechanism of regulation of E2F transcription factor 1 by direct binding of GSK3beta to its transactivation domain |
| 17139249 |
These results imply that GSK-3beta may function in transporting centrosomal proteins to the centrosome by stabilizing the BICD1 and dynein complex, resulting in the regulation of a focused microtubule organization. |
| 12054501 |
Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction |
| 15719395 |
Results indicate that GSK3B may not play a major role in Japanese schizophrenia. |
| 16007092 |
GSK3 has a role in modulating the inflammatory response and toll-like receptor-mediated cytokine production |
| 16421604 |
GSK3beta is not only a critical regulator of proproliferative signalling but also a promiscuous one as PI3K/Akt pools of GSK3beta are, at least in part, functionally interchangeable with those of the Wnt/beta-catenin pathway |
| 16611631 |
GSK3 alters phosphorylation of CRMP-1, -2, and -4 isoforms |
| 15254796 |
the reduction in brain GSK-3beta is reflected in CSF of schizophrenia patients |
| 16912034 |
analysis of critical variations in the function and regulation of GSK-3alpha and GSK-3beta |
| 17241872 |
GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to the dramatic alteration of cell status between proliferation and differentiation in colon cancer |
| 17389597 |
abnormal activation of glycogen synthase kinase 3beta can reduce neuronal viability and synaptic plasticity via modulating Presenilin 1/N-cadherin/beta-catenin interaction and thus have important implications in the pathophysiology of Alzheimer disease. |
| 16420965 |
Our results demonstrate that the flow cytometry-based method is a convenient tool to analyze the effect of GSK-3beta inhibitors on Tau phosphorylation. This |
| 14744935 |
ER stress induces GSK-3beta binding to p53 in the nucleus and enhances the cytoplasmic localization of the tumor suppressor. |
| 15375789 |
overexpression of human GSK-3beta in skeletal muscle of male mice resulted in impaired glucose tolerance despite raised insulin levels |
| 16076840 |
GSK-3 interacts with and phosphorylates ESRalpha and is involved in the regulation of receptor activity |
| 16107342 |
multiple kinases, including CK2 and GSK3beta, participate in PTEN phosphorylation and GSK3beta may provide feedback regulation of PTEN |
| 14536078 |
multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation |
| 14550568 |
GSK3beta is a potential regulator of platelet function |
| 15026145 |
These results suggest that short-term exposure to TNF-alpha augments insulin effects through protein kinase B-alpha and glycogen synthase kinase-3 beta, whereas long-term exposure causes insulin resistance in HepG2 cells. |
| 15178691 |
GSK3 beta may function as a repressor to suppress AR-mediated transactivation and cell growth |
| 16055726 |
GSK3-dependent phosphorylation of Mdm2 regulates p53 abundance |
| 15963640 |
These data indicate that 14-3-3zeta may not be directly interacting with GSK3beta and tau in the brain, but may indirectly facilitate the interactions by binding to other proteins. |
| 15351432 |
A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. |
| 15456937 |
Results propose a new mechanism by which lithium indirectly inhibits glycogen synthase kinase-3beta via phosphatidylinositol 3 kinase-dependent activation of protein kinase C alpha. |
| 16371352 |
inhibition of GSK-3beta stimulates COX-2 expression in gastric cancer cells |
| 14520463 |
Increased expression of glycogen synthase kinase 3 is associated with ovarian epithelial cell transformation and in tumour progression |
| 16174773 |
GSK3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH |
| 12167628 |
GSK3beta functions at the nodal point of converging signaling pathways in endothelial cells to regulate vessel growth through its control of vascular cell migration and survival. |
| 12871932 |
molecular cross-talk between glycogen synthase kinase-3 beta (GSK-3 beta) and the p105 precursor of the NF-kappa B p50 subunit |
| 12900420 |
glycogen synthase kinase-3beta is suppressed by Akt in prostate cancer cells which leads to the phosphorylation of cAMP-response element-binding protein |
| 14985354 |
glycogen synthase kinase-3 beta phosphorylates the androgen receptor, thereby inhibiting androgen receptor-driven transcription |
| 15522877 |
FRAT-2 enhances GSK3 beta-mediated phosphorylation of a primed substrate to a greater extent than an unprimed substrate |
| 12379450 |
Fresh lymphocytes from schizophrenic patients showed no difference in GSK-3 alpha and GSK-3beta mRNA levels, GSK-3beta protein levels, or total GSK-3 (alpha+beta) enzyme activity compared with findings in control subjects. |
| 12566926 |
plays a role in Alzheimer disease and other CNS disorders (REVIEW) |
| 12130654 |
GSK3b binds to and phosphorylates serine493 in glutamate E segment of NEFH |
| 16315267 |
GSK3B polymorphisms alter transcription and splicing and interact with Tau haplotypes to modify disease risk in Parkinson disease |
| 17387146 |
Results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization. |
| 17434145 |
Our results imply that phosphorylation of serine 256 in ataxin-3 by GSK 3beta regulates ataxin-3 aggregation. |
| 12554650 |
Data report the crystal structure of glycogen synthase kinase 3beta (GSK3beta) in complex with a minimal GSK3beta-binding segment of axin, at 2.4 A resolution. |
| 11986994 |
signaling systems determining cell fate appear to be important targets of mood stabilizers, and these may include signaling pathways encompassing GSK3beta, including transcription factors regulated by GSK3beta(REVIEW) |
| 15073173 |
GSK3beta is connected to tau by 14-3-3 and Ser(9)-phosphorylated GSK3beta phosphorylates tau |
| 12376533 |
GSK3b expresion is regulated by reelin |
| 15517997 |
In transgenic mice, GSK3betaS9A resulted in hyperphosphorylation of tau and morphology reminiscent of pretangle-like neurons in cortex and hippocampus. |
| 16257959 |
GSK-3beta directly phosphorylates and activates MARK2/PAR-1 |
| 16543145 |
The results demonstrate that the control of MCL-1 stability by GSK-3 is an important mechanism for the regulation of apoptosis by growth factors, PI3K, and AKT. |
| 16934436 |
These results suggest i) an essential role of PI3K/Akt/GSK-3alpha/beta signaling for a successful replication of VZV and ii) a key function of VZV kinases pORFs 47 and 66 to activate this pathway. |
| 17028556 |
GSK-3B is the missing link between the amyloid and tau-pathology, and position GSK-3B as prominent player in the pathogenesis in Alheimer disease. |
| 17357145 |
GSK3beta may be involved in Bipolar Disorder susceptibility in some individuals. |
| 12147701 |
A-kinase anchoring protein AKAP220 binds to this enzyme and mediates protein kinase A-dependent inhibition of GSK-3beta |
| 14523002 |
role in binding to and promoting action of p53 |
| 14988390 |
Most importantly, knocking down GSK-3beta expression via a small interference RNA-mediated gene silencing approach also reduced R1881-stimulated gene expression, demonstrating the specificity of GSK-3beta involvement. |
| 14988008 |
Clozapine appears to regulate the phosphorylation of GSK3B through Wnt signal pathways involving Dvl upstream but not through the P13K-Akt pathway in human neuroblastoma cells. |
| 16210249 |
These results identify glycogen synthase kinase 3beta and FBW7 as potential cancer therapeutic targets and MYC as a critical substrate in the GSK3beta survival-signaling pathway. |
| 16278684 |
GSK-3, acting through PKCdelta, is a negative regulator of ERK1/2 |
| 12244165 |
GSK-3 beta is inhibited by endothelial cell costimulation, allowing nuclear accumulation of NFAT and prolonging IL-2 synthesis in the presence of cyclosporin A. |
| 12364325 |
inhibition of GSK3beta activity appears to trigger nuclear accumulation of cyclin D1 and cell cycle progression |
| 12584189 |
GSK3 beta functions as a natural activator of MEKK1 |
| 15252116 |
GSK-3beta has a role in cAMP-induced degradation of cyclin D3 |
| 14729229 |
No association was detected between GSK3-beta -50 T/C SNP and the presence of bipolar illness. Homozygotes for the wild variant (T/T) showed an earlier age at onset than carriers of the mutant allele (F=5.53, d.f.=2,182, P=0.0047). |
| 15940626 |
a unique cooperative interaction possible between 2 critical oncogenic pathways in colorectal tumorigenesis, and pivotal role of GSK-3beta suggested |
| 15555766 |
Total GSK-3 protein was increased in both Alzheimer's disease and in mild cognitive impairment without a compensatory decrease in activity |
| 15993040 |
These findings suggest that glycogen synthase kinase-3beta is involved in hydrogen peroxide-mediated inhibition of Tcf/Lef-dependent transcriptional activity. |
| 16397405 |
A trend was found towards an association for the C allele in the whole group of schizophrenic patients and for the heterozygous T/C genotype of bipolar patients. |
| 16705181 |
Multisite glycogen synthase kinase 3beta (GSK3beta) phosphorylation and ubiquitination by SCFbetaTrCP are required for Gli3 processing. |
| 16757548 |
there is tissue specificity for the regulation of GSK-3 in humans; in skeletal muscle GSK-3 plays a role in control of metabolism and insulin action, whereas the function in adipose tissue is less clear |
| 16982692 |
this study provides, for the first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-dependent manner. |
| 12086949 |
improves insulin action and glucose metabolism in skeletal muscle |
| 14691449 |
CF101 inhibits human colon carcinoma growth in mice via modulation of GSK3B. |
| 14991743 |
APC/GSK-3beta, through beta-catenin, may crossregulate NF-kappaB signaling pathway |
| 16341242 |
GSK-3 is a specific in vivo modulator of hematopoietic stem cell activity |
| 16767496 |
Hypertonic conditions induced with NaCl and other osmolytes were used to stimulate several tumor cell lines, Glycogen Synthase Kinase 3beta (GSK3beta) was rapidly dephosphorylated at serine 9 and its kinase activity was increased. |
| 16984735 |
NT uses PKC-dependent pathways to modulate GSK-3, which may play a role in the NT regulation of intestinal cell growth |
| 17072303 |
The identification of a beta-catenin-T-cell factor-regulated Axin2-GSK3beta-Snail1 axis provides new mechanistic insights into cancer-associated epithelial-mesenchymal transition programmes. |
| 17273789 |
IL-6, via the PI3-kinase/Akt pathway leads to inhibition of the repressive kinases MAPK/pERK and GSK3beta, and this converts inactive HSF-1 to an intermediate DNA-binding form augmenting transcriptional activation in the presence of a second stressor. |
| 17325032 |
direct regulation of hypoxia-inducible factor 1 alpha subunit stability by GSK-3 may influence physiological processes or pathophysiological situations such as metabolic diseases or tumors |
| 16916907 |
We demonstrate, for the first time in human skeletal muscle, that the regulation of Akt and its downstream signalling pathways GSK-3beta, mTOR and Foxo1 are associated with both the skeletal muscle hypertrophy and atrophy processes. |
| 11967263 |
Arg(96) mutant has a dominant-negative effect on GSK-3beta-dependent phosphorylation of beta-catenin and targeting of beta-catenin for degradation requires prior priming through phosphorylation of Ser(45) |
| 12761178 |
first demonstration that glycogen synthase kinase-3beta associates with type 1 protein phosphatase/inhibitor-2 (PP1C/I-2) complex and phosphorylates I-2 at T72 in intact cells |
| 12228224 |
Data show that endoplasmic reticulum stress induced by thapsigargin not only activated the apoptosis effector caspase-3 but also caused a large and prolonged increase in the activity of glycogen synthase kinase-3beta. |
| 14561750 |
activation of Csk and GSK-3beta by Galphaq may contribute to the physiological and pathological effects of Gq-coupled receptors |
| 12182887 |
Glycogen synthase kinase 3 beta influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3beta. |
| 12796505 |
GSK-3 regulates its own phosphorylation status |
| 14518171 |
possible role of GSK-3 beta, a pro-apoptotic factor participating in signal transduction involved in cell survival, is discussed in relation to schizophrenia |
| 15799972 |
KCl-induced depolarization causes undulating GSK-3beta phosphorylation/dephosphorylation, which is regulated for the most part by phosphatidylinositol 3-kinase and Akt (phosphorylation) and PP2A and PP2B (dephosphorylation), respectively |
| 14729058 |
GSK3B regulates the cytoskeleton and translocation of Rac1 in keratinocyte lamellipodia. |
| 12603528 |
Messenger RNA of beta-catenin and Tcf-4, but not GSK-3beta, was found to be overexpressed in HCC(hepatocellular carcinoma). |
| 15981102 |
No significant genetic alterations were found. |
| 16198352 |
findings suggest the ERK/MAPK and PI3K pathways may regulate VEGF expression in part through regulating the action of these repressor proteins |
| 16462886 |
Cytokine-dependent GSK-3 phosphorylation in hemopoietic cells proceeds primarily through Protein Kinase B independent pathways. |
| 16571670 |
protection of beta-catenin from ubiquitination and proteasomal degradation induced by glycogen synthase kinase (GSK)-3beta inhibition |
| 16788573 |
Results suggest that glycogen synthase kinase-3beta activity is important for the proliferation of ovarian cancer cells, implicating this kinase as a potential therapeutic target in ovarian cancer. |
| 16882987 |
Cyclic expression of GSK-3beta's active and inactive forms in the endometrium suggests that sex hormones regulate its expression. In vitro experiments demonstrate that progesterone induces phosphorylation of endometrial GSK-3beta. |
| 16987250 |
This study fails to support reduced signaling of the AKT-GSK3beta molecular cascade in schizophrenia. |
| 17052453 |
S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt |
| 17159916 |
Of special interest was the rapid decrease in expression of MITF in melanocytes treated with DKK1, which is concurrent with the decreased activities of beta-catenin and of glucose-synthase kinase 3beta |
| 17283049 |
This is the first demonstration of GSK-3beta as the missing link between UV-induced ATR activation and p21 degradation. |
| 14617795 |
a mechanism involving GSK-3beta activation may be responsible for tumor necrosis factor-related apoptosis-inducing ligand resistance in prostate cancer cells |
| 15609321 |
GSK3 and PKB/Akt have roles in the integrin-mediated regulation of PTHrP, IL-6 and IL-8 in pancreatic cancer |
| 14660640 |
TSH/cAMP-stimulated p70S6 kinase activity and cell proliferation is regulated by Rap1GAP in thyroid cells |
| 15752768 |
In kinase assay, we also showed that CABYR variants act as an ideal substrate for GSK3beta within the extensin-like domain and phosphorylation sites on CABYR were mapped. |
| 16428445 |
GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness. |
| 16551619 |
GSK3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2 |
| 16893889 |
substrate recognition involves interactions with GSK-3beta residues: Phe67, Gln89, and Asn95, which confer a common basis for substrate binding and selectivity, yet allow for substrate diversity |
| 16942622 |
GSK3 activity has little influence over cyclin D1 expression levels during any cell cycle phase. |
| 16981698 |
GSKIP is a naturally occurring protein that is homologous with the GSK3beta interaction domain of Axin and is able to negatively regulate GSK3beta of the Wnt signaling pathway. |
| 17107957 |
R-Ras and ILK have roles upstream of GSK-3beta in the regulation of neuronal polarity |
| 17150190 |
We conclude that hCSCs exhibit mesenchymal features and that Akt/GSK-3beta may be crucial modulators for hCSC maintenance in human heart. |
| 15942663 |
GSK-3beta reactivation is involved in the process through which LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis via death receptor and mitochondria signalling pathways |
| 17475833 |
Unrestrained glycogen synthase kinase 3 beta is responsible for growth factor withdrawal induced activated T cell death. |
| 11495916 |
The intracellular distribution of GSK-3 beta is dynamically regulated by signaling cascades, and apoptotic stimuli cause increased nuclear levels of GSK-3 beta, which facilitates interactions with nuclear substrates. |
