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GSN


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Symbol:GSN
Name(s):gelsolin (amyloidosis, Finnish type)
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp313L0718
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17982131 TP53 mutations are frequent events in bladder cancer progression and gelsolin relates to TP53 status, tumor staging and clinical outcome.
17556051 analysis of distinct sites of interaction that form the calponin: gelsolin complex and two calcium switches that control its activity
16882345 higher expression in MCM2 and gelsolin was significantly associated with poorer prognosis in patients with NSCLC, which suggests that higher tumor proliferation and motility may be important in the prognosis of NSCLC
15922735 Mechanisms of GSN dependent and independent EGF stimulated cell motility were studied in an epithelial cell line.
17254575 gelsolin G5 domain inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC
16008344 The tight interaction between plasma gelsolin and endotoxin/lipopolysaccharide (LPS) affects both gelsolin's actin binding function and some aspects of the effects of LPS on cells.
12270712 explores the structure-function relationship of the gelsolin-PPI interaction
15538717 features of gelsolin amyloidogenic fragments comprised of residues 173-243 and residues 173-202 were investigated
12833632 Gelsolin and plasminogen activator inhibitor-1 have roles as Ap3A-binding proteins
15213223 gelsolin protects cells from butyrate-induced apoptosis

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActin alpha, skeletal muscle 1gelsolin isoform a precursor--Pubmed
HPRDalpha 1 actin precursorGelsolin--Pubmed
HPRDActin betagelsolin isoform a precursor--Pubmed
HPRDbeta actinGelsolin--Pubmed
HPRDActinin alpha 4gelsolin isoform a precursor--Pubmed
HPRDactinin, alpha 4Gelsolin--Pubmed
HPRDAmyloid beta A4 proteingelsolin isoform a precursor--Pubmed
HPRDamyloid beta A4 protein precursor, isoform aGelsolin--Pubmed
HPRDandrogen receptor isoform 1gelsolin isoform a precursor--Pubmed
HPRDandrogen receptor isoform 1gelsolin isoform a precursor--Pubmed

Recent Publications on GSN:

Pubmed Logo
Exclusion of known corneal dystrophy genes in an autosomal dominant pedigree of a unique anterior membrane corneal dystrophy.
PURPOSE: With advances in phenotyping tools and availability of molecular...
29th October, 2009
Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Mol Vis. 2009 Aug 26;15:1700-8.
A critical role for gelsolin in ventilator-induced lung injury.
Mechanical ventilation, an essential life-support modality of patients...
21st October, 2009
Marianthi Simou Lab, Evaggelismos Hospital, University of Athens Medical Am J Respir Cell Mol Biol. 2009 Oct;41(4):426-32. Epub 2009 Feb 6.
DOI Direct Link
[Study on proteomic specificity of unstable angina with qi deficiency and blood stasis syndrome]
OBJECTIVE: To seek the special plasma molecule in unstable angina (UA)...
26th August, 2009
Beijing University of Chinese Medicine, Beijing. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jun;29(6):489-92.
Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart.
PURPOSE: Gelsolin (gsn) is involved in the reorganization of the...
12th August, 2009
Department of Medicine-Cardiology, University of Bonn, Sigmund Freud J Interv Card Electrophysiol. 2009 Oct;26(1):3-10. Epub 2009 Aug 8.
DOI Direct Link
Identification of endogenous reference genes for qRT-PCR analysis in normal matched breast tumor tissues.
Quantitative gene expression measurements from tumor tissue are frequently...
16th July, 2009
Department of Molecular Biology and Genetics, Faculty of Science, Bilkent Oncol Res. 2009;17(8):353-65.

View more research publications.

Press Releases on GSN:

BioPortfolio Logo
Nationally Known Psychotherapist Dr. Robi Ludwig Joins Qualsec's Wholly-Owned Subsidiary VitaminSpice 4th November, 2009 Qualsec

WAYNE, Pa., Nov. 4 /PRNewswire-FirstCall/ -- Qualsec (OTC Bulletin Board: QLSZ; German WKN: A0YCND), which recently acquired VitaminSpice, LLC, announced that Dr Robi Ludwig, Psy.D., a

HSW International Joins in Founding Sharecare, Inc. and Will Provide Technology Development Services To Build Its Web 3.0 Platform 2nd November, 2009 HSW International, Inc.

Sharecare Inc., created by Jeff Arnold and Dr. Mehmet Oz, in partnership with Harpo Productions, HSW International, Sony Pictures Television, and Discovery Communications, is a highly searchable

Dr. Mehmet Oz and Internet Entrepreneur, Jeff Arnold, Announce Sharecare Inc., a Web 3.0 Platform, Organizing and Answering the Questions of Health 2nd November, 2009 Sharecare Inc.

ATLANTA, Nov. 2 /PRNewswire-FirstCall/ -- WebMD founder and Discovery Communications' Chief of Global Digital Strategy (Nasdaq: DISCA, DISCB, DISCK), Jeff Arnold, and Dr.

VitaminSpice Signs MOU With Seamless Corp. for Sale of VitaminSpice Product Line on the Seamless Websites 30th October, 2009 Qualsec

WAYNE, Pa., Oct. 30 /PRNewswire-FirstCall/ -- Qualsec (OTC Bulletin Board: QLSZ), which recently acquired Vitamin Spice (VitaminSpice.net<

'The Dr. Oz Show' and the National Association of Free Clinics Host One Day Free Public Health Clinic at Houston's Reliant Convention Center on September 26 22nd September, 2009 Sony Pictures Television
-- Those interested in volunteering may signup online at www.regonline.com/tcare.

About "The Dr. Oz Show"

The Dr. Oz Show"

BioNews Results for GSN

: RSS Logo
BioPortfolio Logo
UPDATE 1-Ratiopharm gets at least 10 bids -sources
Reuters:  Nov 11 2009 7:10PM Matching: gsn
UPDATE 1-Ratiopharm gets at least 10 bids -sources
Reuters India:  Nov 11 2009 7:09PM Matching: gsn
At Least 10 Bidders for Ratiopharm
Private Equity HUB:  Nov 11 2009 6:29PM Matching: gsn
At least 10 bids filed in Ratiopharm sale: sources
Reuters:  Nov 11 2009 6:07PM Matching: gsn
At least 10 bids filed in Ratiopharm sale -sources
Reuters:  Nov 11 2009 6:06PM Matching: gsn
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Ascending Single Dose Study of Rhu-pGelsolin in Patients With Decreased Gelsolin Levels

Patents:

Patents logo
US Patent No.Title
7526387 Expression profile algorithm and test for cancer prognosis
7561547 Automatic and seamless vertical roaming between wireless local area network (WLAN) and wireless wide area network (WWAN) while maintaining an active voice or streaming data connection: systems, methods and program products
7563603 PUFA polyketide synthase systems and uses thereof
7563604 PUFA polyketide synthase systems and uses thereof
7563605 PUFA polyketide synthase systems and uses thereof

View more patents.

GSN results (if any) from reagent suppliers

Google CSE Logo
GSN Antibody (C-term)
Western blot analysis of GSN antibody (C-term) (Cat.#AP7326b) in A375, A2058 cell line lysates and mouse lung, bladder tissue lysates (35ug/lane). ...
http://www.abgent.com/products/catalog_no/AP7326b_GSN_Antibo...

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Gelsolin antibody, Gelsolin [GS-2C4] Antibody, Mouse Monoclonal ...
Mouse monoclonal [GS - 2C4] to Gelsolin; 2934; GSN; 105120; P06396; DKFZp313L0718;; Gelsolin, GELS_HUMAN. [ N/A NP_000168.1 P06396 ].
http://www.genwaybio.com/product_info.php?products_id=190365...

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Abgent - Cell and Structure Antibodies - Cell_structure
AT2272a, GSN monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H. AT2320a, HAX1 monoclonal antibody (M04), ELISA,WB-Re,WB-Tr, H ...
http://www.abgent.com/products/category/cell_function/cell_s...

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Gelsolin (C-20) Antibody sc-6405
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GSN, 2934, 9q33.2, NM_000177, ...
http://www.scbt.com/datasheet-6405-gelsolin-c-20-antibody.ht...

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Antibody Products - IgG Monoclonal Antibodies - GenWay
Mouse monoclonal [GS - 2C4] to Gelsolin; 2934; GSN; 105120; P06396; DKFZp313L0718;; Gelsolin, IgG Monoclonal AP, ELISA, IF, WB, Source: Mouse ...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=G...

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Abgent - Cancer Antibodies - Cancer
AP6145a, GROS1 Antibody (C-term), IHC, E, H. AP7469aNEW, GSDMDC1 Antibody (N- term), WB, E, H. AP7326bNEW, GSN Antibody (C-term), WB, E, H ...
http://www.abgent.com/products/category/cell_function/cancer...

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G4896 Monoclonal Anti-Gelsolin antibody produced in mouse clone GS ...
indirect ELISA: suitable. microarray: suitable. isotype, IgG1. Gene Information, human ... GSN(2934). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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