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GSPT1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17700517 |
GSTP1 inhibits the binding of MAP kinase kinase kinase 5 (MAP3K5) to the 14-3-3 protein, a MAP3K5 inhibitor, while a novel role of GSPT1 is revealed in the regulation of apoptosis signal-regulating kinase 1 (ASK1)-mediated apoptosis. |
| 18083835 |
eRF3a is degraded by the proteasome when not associated with eRF1; proteasomal degradation of eRF3a controls translation termination complex formation by adjusting the eRF3a level to that of eRF1. |
| 17562865 |
These results strongly suggest that the G1 arrest and the decrease in translation induced by eRF3a depletion are due to the inhibition of mTOR activity and hence that eRF3a belongs to the regulatory pathway of mTOR activity. |
| 15987717 |
Polyglycine expansions in eukaryotic translation release factor 3 are associated with gastric cancer susceptibility |
| 15908960 |
Human translation termination factor eRF3/GSPT1 is an interacting partner of RNase L. |
| 16452507 |
Further, we describe a novel complex that contains the NMD factors SMG-1 and Upf1, and the translation termination release factors eRF1 and eRF3 (SURF). an association between SURF and the EJC is required for SMG-1-mediated Upf1 phosphorylation and NMD. |
| 12865429 |
GSPT1/eRF3 is proteolytically processed into an IAP-binding protein |
| 15987998 |
eRF3a controls the formation of the termination complex by modulating eRF1 protein stability. |
Recent Publications on GSPT1: |  |
eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development.
It is now widely recognized that translation factors are involved in... | 10th July, 2009
| Escola Superior de Tecnologia da Saude de Lisboa, 1990-096 Lisboa,
| Oncol Rep. 2009 Jun;21(6):1551-8.
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Translation termination and protein folding pathway genes are not correlated in gastric cancer.
BACKGROUND: The eukaryotic release factor 3 (eRF3) has been shown to... | 13th June, 2009
| Escola Superior de Tecnologia da Saude de Lisboa, Lisboa, Portugal.
| Clin Chem Lab Med. 2009;47(4):427-31.
DOI Direct Link |
Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors.
INTRODUCTION: Estrogen receptor (ER)-positive breast cancers are... | 13th November, 2008
| Department of Molecular Oncology, The John Wayne Cancer Institute, Saint
| Breast Cancer Res. 2008;10(3):R46. Epub 2008 May 16.
DOI Direct Link |
G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1.
Apoptosis signal-regulating kinase 1 (ASK1), a member of the... | 13th March, 2008
| College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.
| Oncogene. 2008 Feb 21;27(9):1297-305. Epub 2007 Aug 20.
DOI Direct Link |
Newer potential biomarkers in prostate cancer.
Prostate-specific antigen (PSA) screening has led to a significant rise in... | 31st January, 2008
| Department of Urology, University of Washington School of Medicine
| Rev Urol. 2007 Fall;9(4):207-13.
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→View more research publications. |
GSPT1 results (if any) from reagent suppliers | 
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eRF3/GSPT1 antibodies: Chromatin and Nuclear Signaling > DNA / RNA ...
eRF3/GSPT1 antibodies. ... eRF3/GSPT1 antibody. IP, WB. Rabbit polyclonal. Reacts with: Hu. Predicted: Ms, Rat, CynMk, Rb, Zfsh ...
http://www.abcam.com/index.html?t=123013&pt=1&c=899&ei=&mu=r...
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Anti-eRF3a/GSPT1 (E4781) - Data Sheet
Anti-eRF3a/GSPT1 produced in rabbit, affinity isolated antibody. Product Number E4781. Product Description. Anti-eRF3a/GSPT1 is developed in rabbit using as ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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Antibodies to Nuclear Proteins
E4656, Anti-eRF3a/GSPT1 (N-terminal) antibody produced in rabbit, (polyclonal), IgG fraction of antiserum, human ... GSPT1(2935), human, IP, WB, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....
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Anti-eRF3a/GSPT1 (N-terminal) (E4656) - Data Sheet
to amino acids 99-116 of human eRF3a/GSPT1 ... human eRF3a/GSPT1. Applications include immuno- ... homologues were identified and named eRF3a/GSPT1 ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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All Ribosome | Abcam
eRF3/GSPT1 antibody. IP, WB. Rabbit polyclonal. Reacts with: Hu. Predicted: Ms, Rat, CynMk, Rb, Zfsh. ab30834 · eRF3/GSPT1 peptide ...
http://www.abcam.com/index.html?c=895...
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eRF3a (S-13) Antibody sc-109537
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, GSPT1, 2935,
16p13. ...
http://www.scbt.com/it/datasheet-109537-erf3a-s-13-antibody....
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Abcam antibodies and reagents product map
... eRF1 antibodies (2) · eRF1 proteins and peptides (2) · eRF3/GSPT1 antibodies (2) · eRF3/GSPT1 proteins and peptides (1) · eRF3B/GSPT2 antibodies (1) ...
http://www.abcam.com/index.html?c=250...
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