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GTF2B

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Symbol:	GTF2B
Name(s):	general transcription factor IIB
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	TF2B, TFIIB
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
12972613	TFIIB interacts with SP1/SP3 at the SP1 site, besides its association with EAR3 and the TATA-less core promoter region.
14641108	The structural role of Zn2+ binding to the the zinc-ribbon domain of TFIIB was analysed.
12529369	interaction with vitamin D receptor helix H10 residues
12535529	Data show that human TATA box binding protein (TBP) can use a shared surface to interact with two different transcription factor IIB (TFIIB) family members to initiate transcription by different RNA polymerases.
15037660	A TFIIB conformational change is critical for the formation of activator-dependent transcription complexes.
15024075	Results identify a small nonconserved surface of the transcription factor TFIIB zinc ribbon that is required for RNA polymerase II (pol II) transcription in vivo and for different types of basal pol II transcription in vitro.
12791683	lack of role in bending of TATA-binding protein simultaneously with promotoer DNA
16595664	high level of TFIIB can bypass the Mediator requirement for basal transcription and pol II recruitment in nuclear extract
14585974	in addition to its role in regulating TBP binding to a TATA box, the TBP surface is unexpectedly involved in TBP association with all three TFIIB family members
16878124	Together, our results support a mode of preinitiation complex assembly in which TFIIB/RNA polymerase II recruitment to the promoter occurs in vivo.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	Human bax gene, 5' region.	general transcription factor IIB	GTF2B (TFIIB) interacts with the Bax promoter.	-	Pubmed
BIND	E1A binding protein p300	general transcription factor IIB	p300 interacts with TFIIB. This interaction is modelled on a demonstrated interaction between human p300 and TFIIB from an unspecified species.	-	Pubmed
HPRD	TFIIA alpha, p55 isoform 1	general transcription factor IIB	-	-	Pubmed
HPRD	TFIIA alpha, p55 isoform 1	general transcription factor IIB	-	-	Pubmed
HPRD	Transcription initiation factor IIB	TBP-associated factor 1 isoform 1	-	-	Pubmed
HPRD	Transcription initiation factor IIB	TBP-like 1	-	-	Pubmed
HPRD	Transcription initiation factor IIB	nuclear receptor coactivator 3	-	-	Pubmed
HPRD	general transcription factor IIB	TBP like 1	-	-	Pubmed
BIND	general transcription factor IIB	vitamin D receptor	VDR interacts with hTFIIB.	-	Pubmed
HPRD	general transcription factor IIB	TAF9 RNA polymerase II isoform a	-	-	Pubmed

Recent Publications on GTF2B:
Gene expression of AGS cells stimulated with released proteins by Helicobacter pylori. BACKGROUND AND AIM: Interactions between released proteins by Helicobacter...	20th August, 2008	Department of Internal Medicine, Seoul National University Bundang	J Gastroenterol Hepatol. 2008 Apr;23(4):643-51. Epub 2007 Dec 5. DOI Direct Link
Involvement of GTA protein NC2beta in neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation. BACKGROUND: The General Transcription Apparatus (GTA) comprises more than...	14th August, 2008	Dipartimento di Scienze Biomediche, Sezione di Biologia Generale, Biologia	Mol Cancer. 2008 Jun 6;7:52. DOI Direct Link
Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval. Loss of the short arm of chromosome 1 is frequently observed in many tumor...	25th August, 2004	Human Genetics Laboratory, Queensland Institute of Medical Research,	Genes Chromosomes Cancer. 2004 Sep;41(1):56-64. DOI Direct Link

Patents:
US Patent No.	Title
7547687	Therapeutic treatment methods
7482334	Therapeutic treatment methods
7381526	Assays for drug discovery based on microcompetition with a foreign polynucleotide
7323302	Molecular markers

GTF2B results (if any) from reagent suppliers

Antibody Products - IgG Monoclonal Antibodies - GenWay Mouse monoclonal anti-human GTF2B antibody; General transcription factor TFIIB; S300-II; General transcription factor IIB; Transcription initiation factor ... http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=G...
TFIIB (SI-1) Antibody sc-274 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GTF2B, 2959, 1p22.2, NM_001514 ... http://www.scbt.com/datasheet-274-tfiib-si-1-antibody.html...
TFIIB (2F6A3H4) Mouse mAb #4169 TFIIB (also known as GTF2B, TF2B and general transcription factor IIB) is a ubiquitously expressed transcription factor that plays a central role in the ... http://www.cellsignal.com/products/4169.html...
Development of a Novel High Throughput Directional Cloning Platform general transcription factor IIB (GTF2B) heat shock transcription factor 1. HCF- binding transcription factor Zhangfei (ZF). BTF2p44 for transcription factor ... https://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General...

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GTF2B

Gene Information from Publications

Interacting gene products

Recent Publications on GTF2B:

Patents:

GTF2B results (if any) from reagent suppliers