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H2AFX
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18206537 |
Copy number alterations of the H2AFX gene in sporadic breast cancer patients. |
| 17548670 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17851762 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17709392 |
Data suggest that the sequential acetylation and ubiquitination of H2AX by TIP60-UBC13 promote enhanced histone dynamics, which in turn stimulate a DNA damage response. |
| 17925396 |
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage |
| 18001825 |
RNF8 is required for H2AX ubiquitylation after DNA damage. |
| 17548670 |
data support the hypothesis that genetic variation in the H2AFX gene influences genetic susceptibility or resistance to some subtypes of non-Hodgkin lymphoma by contributing to the maintenance of genome stability. |
| 17874213 |
histone H2AX inhibits transcription through phosphorylation and can decrease chromatin movement at DSBs and frequency of misjoining of DNA ends |
| 17327276 |
We propose a model that perturbed gap-filling synthesis following dual incision in NER generates single-strand DNA gaps and hence initiates H2AX phosphorylation. |
| 17634426 |
This is the first report of high ATM-Chk2 kinase activation and its linkage to replication defects in a Bloom syndrome model. | →View more information from publications. |
Recent Publications on H2AFX: |  |
Where did they come from? The origin of endogenous gamma-H2AX foci in tumor cells.
The failure of conventional therapies in glioblastoma (GBM) is largely due... | 31st October, 2009
| National Institutes
| Cell Cycle. 2009 Aug;8(15):2324. Epub 2009 Aug 1.
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gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products.
Differentiation among American cigarettes relies primarily on the use of... | 30th October, 2009
| Vector Tobacco Inc., Public Health, 712 Fifth Avenue, 52nd Floor, New
| Mutat Res. 2009 Aug;678(1):43-52. Epub 2009 Jul 8.
DOI Direct Link |
High throughput evaluation of gamma-H2AX.
The DNA double-strand break (DSB) is the primary lethal lesion after... | 29th October, 2009
| Radiation Oncology Branch, National Cancer Institute, National Cancer
| Radiat Oncol. 2009 Aug 24;4:31.
DOI Direct Link |
Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis.
Maintenance of genome integrity is essential for homeostasis and survival... | 29th October, 2009
| Institute of Cancer Biology and Centre for Genotoxic Stress Research,
| Cell Cycle. 2009 Aug 15;8(16):2592-9. Epub 2009 Aug 21.
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Intercellular communication of cellular stress monitored by gamma-H2AX induction.
When cells are exposed to ionizing radiation (IR), unexposed cells that... | 27th October, 2009
| Laboratory of Molecular Pharmacology, Center for Cancer Research, National
| Carcinogenesis. 2009 Oct;30(10):1686-95. Epub 2009 Aug 3.
DOI Direct Link |
→View more research publications. |
H2AFX results (if any) from reagent suppliers | 
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p-Histone H2A.X (Ser 139) Antibody sc-101696
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, H2AFX, 3014, 11q23.3, NM_002105 ...
http://www.scbt.com/datasheet-101696-p-histone-h2a.x-ser-139...
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Antibody Products - IgG Polyclonal Antibodies - GenWay
X; 3014; H2AFX; 601772; P16104; H2A.X; H2A/X; H2AX;; Histone H2A.x, IgG Polyclonal IF, IP, WB ... Rabbit Anti Human H2AX; 3014; H2AFX; 601772; P16104;
H2A. ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=H...
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H5912 Anti-phospho-Histone H2AX (pSer139) antibody produced in ...
microarray: suitable. Gene Information, human ... H2AFX(3014). mouse ... H2afx( 15270). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en...
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NBS1 antibody, NBS1 [1D7] Antibody, Mouse Monoclonal Antibody
Domain: The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AFX and for relocalization of MRE11/RAD50 complex to the
...
http://www.genwaybio.com/product_info.php?products_id=193314...
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Antibodies to Histone Modifications
H2afx(15270), mouse, human, ARR, WB, pricing. H0412, Anti-phospho-Histone H3 ( pSer10) antibody produced in rabbit, (polyclonal), IgG fraction of antiserum ...
https://www.sigmaaldrich.com/etc/controller/controller-page....
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Abgent - Chromatin and Regulation Antibodies - Chromatin_regulation
AP7131b, Glycerol kinase (GPK2) Antibody (C-term), WB, IHC, E, H. AT2306aNEW, H2AFX monoclonal antibody (M05), ELISA,S-ELISA, H ...
http://www.abgent.com/products/category/nuclear_signaling/ch...
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H2AX Antibody Bethyl Laboratories
Alternate Names, Histone H2AX; Histone H2AFX; Histone H2A.X, Histone H2A/X. Type , Polyclonal. Form, Antigen Affinity Purified. Conjugate, Unconjugated ...
http://www.bethyl.com/go/?product/A300-083A...
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