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ANXA2


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Symbol:ANXA2
Name(s):annexin A2
Type:protein-coding
Organism:Homo sapiens
Synonyms:ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17999956 the annexin II-S100A10 complex, which regulates exocytosis, forms a ternary complex with TrpRS.
15784727 Observational study of gene-disease association. (HuGE Navigator)
18084608 IRF-1 silencing with siRNA produced upmodulation of the Annexin-II protein in THP-1 cells.
17824845 analysis of the pH-induced membrane binding of annexins A6 and A2-S100A10
17709546 uPA plays a major role in inducing MMP-1 production in activated human monocytes, which is mediated by a plasmin-dependent mechanism involving signaling through the annexin A2 heterotetramer.
17581860 The anx 2-S100A10/CFTR complex is important for CFTR function across epithelia.
17513451 following injury, N-glycosylation events and AII presentation on the cell surface of airway epithelial cells are important mediators in repair
16493010 anti-A2 antibodies contribute to the prothrombotic diathesis in antiphospholipid syndrome
15226372 Experiments using individual subunits identify annexin 2 as a PtdIns(4,5)P(2)-binding entity
16709165 Review discusses a role for annexin 2 in the regulation of ecto-5'-nucleotidase activity, which is dependent upon the stability of the membrane rafts.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAnnexin IIS100A6 protein--Pubmed
HPRDAnnexin IIapolipoprotein H precursor--Pubmed
HPRDAnnexin IIproto-oncogene tyrosine-protein kinase SRC--Pubmed
HPRDAnnexin IIlysophospholipase I--Pubmed
HPRDAnnexin IIphospholipase A1 member A--Pubmed
HPRDannexin A2 isoform 2Lysophospholipase I--Pubmed
HPRDannexin A2 isoform 2PSPLA1--Pubmed
HPRDannexin A2 isoform 2Phospholipase A1 member A--Pubmed
HPRDannexin A2 isoform 2Calcyclin--Pubmed
HPRDannexin A2 isoform 2Calpactin I, light chain--Pubmed

Recent Publications on ANXA2:

Pubmed Logo
Role of annexin A2 in cellular entry of rabbit vesivirus.
The mechanisms of calicivirus attachment and internalization are not well...
31st October, 2009
Departamento de Bioquimica y Biologia Molecular, Instituto Universitario J Gen Virol. 2009 Nov;90(Pt 11):2724-30. Epub 2009 Jul 15.
DOI Direct Link
Proteomics analysis of regenerating amphibian limbs: changes during the onset of regeneration.
During amphibian epimorphic limb regeneration, local injury produces...
20th October, 2009
Indiana University Center for Regenerative Biology and Medicine, Indiana Int J Dev Biol. 2009;53(7):955-69.
DOI Direct Link
The Physiologic Effects of Caloric Restriction Are Reflected in the in Vivo Adipocyte-Enriched Proteome of Overweight/Obese Subjects.
We have applied our recently designed proteomics apparoach to search for...
16th October, 2009
NUTRIM School for Nutrition, Toxicology and Metabolism, Department of J Proteome Res. 2009 Oct 27.
DOI Direct Link
S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.
BACKGROUND: High levels of S100A6 have been associated with poor outcome...
15th October, 2009
Division of Surgery and Oncology, University of Liverpool, Liverpool, UK. Br J Cancer. 2009 Oct 6;101(7):1145-54. Epub 2009 Sep 1.
DOI Direct Link
Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy.
The peribiliary inflammation of cholangiopathy affects the physiological...
14th October, 2009
Division of Gastroenterology, Tohoku University Graduate School of Lab Invest. 2009 Oct 12.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Treatment of Acute Promyelocytic Leukemia With All-Trans Retinoic Acid (ATRA) and Idarubicin (AIDA)

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
6759508 Compositions and methods for the therapy and diagnosis of lung cancer
6867283 Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

ANXA2 results (if any) from reagent suppliers

Google CSE Logo
ANXA2 Antibody (N-term)
Western blot analysis of anti-ANXA2 Antibody (N-term) (Cat.#AP7420a) in mouse lung tissue lysates (35ug/lane). ANXA2(arrow) was detected using the purified
...
http://www.abgent.com/products/catalog_no/AP7420a_ANXA2_Anti...

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Growth Factors/Hormones/Hormone Receptors(758) - GeneTex Inc ...
ANXA2 antibody (annexin A2), GTX100046, Rabbit PAb, WB, 100 μg, USD $269.00, -. ANXA2 antibody (annexin A2), GTX101902, Rabbit ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

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ANXA2 Antibody (C-term)
Western blot analysis of anti-ANXA2 Antibody (C-term) (Cat.#AP7420b) in A2058 cell line lysates (35ug/lane). ANXA2(arrow) was detected using the purified ...
http://www.abgent.com/products/catalog_no/AP7420b_ANXA2_Anti...

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S100A10 antibody (ab50737) | Buy from Abcam
S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target ...
http://www.abcam.com/S100A10-antibody-ab50737.html...

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Annexin II (C-10) Antibody sc-28385
... Protein Accession #, OMIM™ Number. Human, ANXA2, 302, 15q22.2, NM_001002857, NM_001002858, NM_004039 · P07355 · 151740. Mouse, Anxa2, 12306, 9 C, P07356 ...
http://www.scbt.com/datasheet-28385-annexin-ii-c-10-antibody...

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Abgent - Cell and Function Antibodies
AT1148aNEW, ANXA2 monoclonal antibody (M01), ELISA,IF,RNAi-Ab,S-ELISA,WB-Ce ... AT1149aNEW, ANXA2 monoclonal antibody (M02), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

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p-Annexin II (85.Tyr 24) Antibody sc-135753
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ANXA2, 302, 15q22.2, P07355 ...
http://www.scbt.com/datasheet-135753-p-annexin-ii-85-tyr-24-...

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