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HABP2


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Symbol:HABP2
Name(s):hyaluronan binding protein 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:FSAP, HABP, HGFAL, PHBP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15486068 Observational study of gene-disease association. (HuGE Navigator)
15543324 Observational study of gene-disease association. (HuGE Navigator)
17003923 Observational study of genotype prevalence. (HuGE Navigator)
17482622 factor VII activating protein (FSAP) was focally accumulated in hypocellular and lipid-rich areas within the necrotic core of atherosclerotic plaques in cornorary arteries
17540775 FSAP is a novel plasma-derived serine protease structurally homologous to tissue-type and urokinase-type plasminogen activators present in bronchoalveolar lavage fluids from patients with acute respiratory distress syndrome.
15486068 The frequency of factor VII-activating protease Marburg I is significantly increased in patients with a history of venous thromboembolism (VTE) or idiopathic VTE compared to healthy controls.
17145954 FSAP has a protective function in the vasculature, and analysis of G534E polymorphism (Marburg I) polymorphism is likely to be clinically relevant in restenosis.
16332249 The identification of polyanion-binding sites will help to define the role of FSAP in the vasculature.
15654766 extracellular RNA, present at sites of cell damage or vascular injury, can serve an important as yet unrecognized cofactor function in haemostasis by inducing (auto-)activation of FSAP through a novel surface-dependent mechanism
17479202 The Marburg I polymorphism of factor VII-activating protease and the risk of venous thromboembolism.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha 1 type IV collagen preproproteinhyaluronan binding protein 2 preproprotein--Pubmed
HPRDalpha 1 type IV collagen preproproteinhyaluronan binding protein 2 preproprotein--Pubmed
HPRDalpha 3 type IV collagen isoform 1, precursorhyaluronan binding protein 2 preproprotein--Pubmed
HPRDalpha 3 type IV collagen isoform 1, precursorhyaluronan binding protein 2 preproprotein--Pubmed
HPRDalpha 4 type IV collagen precursorhyaluronan binding protein 2 preproprotein--Pubmed
HPRDalpha 4 type IV collagen precursorhyaluronan binding protein 2 preproprotein--Pubmed
HPRDCollagen type IV, alpha 5hyaluronan binding protein 2 preproprotein--Pubmed
HPRDalpha 5 type IV collagen isoform 2, precursorHyaluronic acid binding protein 2--Pubmed
HPRDtype IV alpha 6 collagen isoform A precursorHyaluronic acid binding protein 2--Pubmed

Recent Publications on HABP2:

Pubmed Logo
Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells.
BACKGROUND: Platelet-derived growth factor-BB (PDGF-BB) is a profibrotic...
11th August, 2009
Department of Medicine II, Gastroenterology, Justus-Liebig-University Liver Int. 2009 May;29(5):686-91. Epub 2008 Oct 15.
DOI Direct Link
Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions.
Factor VII activating protease (FSAP) is associated with cardiovascular...
3rd July, 2009
Institute for Biochemistry, Medical School, Justus-Liebig-University FEBS Lett. 2009 Jun 18;583(12):1994-8. Epub 2009 May 14.
DOI Direct Link
Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study.
BACKGROUND/OBJECTIVES: Age-related changes in blood coagulation and...
26th June, 2009
Department of Epidemiology, University of Washington, Seattle, WA 98195, J Thromb Haemost. 2009 Sep;7(9):1499-505. Epub 2009 Jun 22.
DOI Direct Link
3-Oxoolean-12-en-27-oic acid isolated from Aceriphyllum rossii induces caspase-8-dependent apoptosis in human promyelocytic leukemia HL-60 cells.
In the present study, we investigated the effects of...
16th April, 2009
College of Pharmacy, Kyung-Hee University, Seoul, Republic of Korea. Biol Pharm Bull. 2009 Jan;32(1):91-8.
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.
Genetic risk factors play an important role for the progression of liver...
2nd April, 2009
Department of Internal Medicine III, University Hospital Aachen, Aachen, Hepatology. 2009 Mar;49(3):775-80.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7442514 Mutants of the factor VII-activating protease and detection methods using specific antibodies
7153679 Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis
6670455 Process for the preparation in pure form of the protease activating blood clotting VII, its proenzyme or a mixture of both proteins by means of affinity chromatography

HABP2 results (if any) from reagent suppliers

Google CSE Logo
HABP2 antibodies: Cardiovascular > Blood > Serum Proteins | Abcam
HABP2 antibodies. ... HABP2 antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. Terms and conditions · Legal · Privacy policy ...
http://www.abcam.com/index.html?t=226850&pt=1&c=488&ei=&mu=r...

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HABP Antibody / HABP Antibodies
HABP2 shRNA Plasmid (m): sc-145887-SH. HABP2 shRNA (m) Lentiviral Particles: sc- 145887-V. HABP4 siRNA (h): sc-92886. HABP4 shRNA Plasmid (h): sc-92886-SH ...
http://www.scbt.com/table-habp.html...

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Abcam antibodies and reagents product map
... Guinea Pig Albumin antibodies (1) · HABP2 antibodies (2) · HGF activator antibodies (5) · HMW Kininogen Heavy Chain antibodies (1) · HRG antibodies (4)
...
http://www.abcam.com/index.html?c=253...

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HABP2 siRNA (m) sc-145887
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: HABP2 ...
http://www.scbt.com/ko/datasheet-145887-habp2-sirna-m.html...

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