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HARS


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Gene DB Home
Symbol:HARS
Name(s):histidyl-tRNA synthetase
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ20491, HRS
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17785330 clinical and prognostic profiles of 45 patients displaying anti-histidyl-tRNA synthetase autoantibodies were determined
17665459 A proteolytically sensitive conformation of HisRS exists in the lung, the target tissue associated with this autoantibody response.
12802020 the TSG101 interaction with HRS is a crucial step in endocytic down-regulation of mitogenic signaling and this interaction may have a role in linking the functions of early and late endosomes
12471150 Demonstrating histidyl-tRNA synthetase (Jo-1)-specific T cell responses represents a key step in establishing the hypothesis that Jo-1 drives T cell-mediated autoimmunity in Jo-1+ polymyositis.
12056811 genomic organization of the HARS locus and mapping of transcripts originating from a bi-directional promoter controlling the differential expression of these gene

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDeukaryotic translation elongation factor 1 beta 2histidyl-tRNA synthetaseHRS interacts with EF-1-beta.-Pubmed
HPRDeukaryotic translation elongation factor 1 gammahistidyl-tRNA synthetase--Pubmed
BINDeukaryotic translation elongation factor 1 gammahistidyl-tRNA synthetaseHRS interacts with EF-1-gamma.-Pubmed
HPRDHistidyl-tRNA synthetaseribosomal protein L5--Pubmed
HPRDHistidyl-tRNA synthetasethreonyl-tRNA synthetase--Pubmed
HPRDhistidyl-tRNA synthetaseRibosomal protein L5--Pubmed
HPRDhistidyl-tRNA synthetaseThreonyl tRNA synthetase--Pubmed

Recent Publications on HARS:

Pubmed Logo
Long-term effectiveness and prediction of treatment outcome in cognitive behavioral therapy and sertraline for late-life anxiety disorders.
ABSTRACTBackground: Although anxiety disorders are prevalent in older...
29th October, 2009
Department of Clinical Psychology, Vrije Universiteit, Amsterdam, The Int Psychogeriatr. 2009 Dec;21(6):1148-59.
DOI Direct Link
Xplor 2--an optimized transformation/expression system for recombinant protein production in the yeast Arxula adeninivorans.
Combining ease of genetic manipulation and fermentation with the ability...
29th October, 2009
Leibniz-Institut fur Pflanzengenetik und Kulturpflanzenforschung (IPK), Appl Microbiol Biotechnol. 2009 Sep;84(3):583-94. Epub 2009 Aug 12.
DOI Direct Link
Pheromone-induced olfactory memory in newborn rabbits: Involvement of consolidation and reconsolidation processes.
Mammary pheromone (MP)-induced odor memory is a new model of appetitive...
29th September, 2009
Centre Europeen des Sciences du Gout, UMR CNRS-Universite de Learn Mem. 2009 Jul 22;16(8):470-3. Print 2009.
DOI Direct Link
[Fall prevention: a challenge in the strategy of fracture prevention in the elderly]
Fracture risk depends on density and quality of bone but also on fall...
12th September, 2009
Departement de rehabilitation et geriatrie, Service des maladies osseuses, Rev Med Suisse. 2009 Jun 10;5(207):1318-20, 1322-4.
Approach memory turns to avoidance memory with age.
Ontogenetic modification of an early memory is relatively poorly...
20th August, 2009
Universite Paris-Sud, UMR 8620, Orsay F-91405, France. Behav Brain Res. 2009 Sep 14;202(2):278-84. Epub 2009 Apr 11.
DOI Direct Link

View more research publications.

Press Releases on HARS:

BioPortfolio Logo
Bolder BioTechnology Receives $1.9 Million NIH Grant to Continue Development of Long-Acting Growth Hormone Product 16th December, 2008 Bolder BioTechnology, Inc.

BOULDER, Colo., Dec. 16 /PRNewswire/ -- Bolder BioTechnology, Inc. today announced that it has been awarded a $1.9 million Phase II Small Business Innovation Research (SBIR)

Clinical Trials:

Clinical Trials Logo
Safety and Efficacy Trial of Subcutaneously Administered Serostim® in the Treatment of Human Immunodeficiency Virus-Associated Adipose Redistribution Syndrome (HARS)

Patents:

Patents logo
US Patent No.Title
7314925 Constructs and methods for expression of recombinant HCV envelope proteins
7392392 Forensic digital watermarking with variable orientation and protocols
7392394 Digital watermarking with variable orientation and protocols
7400743 Methods to evaluate images, video and documents
7424131 Authentication of physical and electronic media objects using digital watermarks

View more patents.

HARS results (if any) from reagent suppliers

Google CSE Logo
HARS antibodies: Immunology > Immune System Diseases > Autoimmune ...
HARS antibodies. ... HARS antibody - Aminoterminal end. IHC-P, WB, ELISA. Images . Rabbit polyclonal. Reacts with: Hu. ab50835 · HARS antibody [HARSA6] ...
http://www.abcam.com/index.html?t=204480&pt=1&c=2241&ei=&mu=...

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HARS Antibody / HARS Antibodies
HARS Antibody / HARS Antibodies. ... HARS specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ...
http://www.scbt.com/ko/table-hars.html...

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Abgent - Translation and Regulation Antibodies ...
AT2313aNEW, HAMP monoclonal antibody (M02), ELISA,IHC-P,S-ELISA,WB-Re, H. AP7567a, HARS Antibody (N-term), WB, IHC, E, H. AP7584b, HARS2 Antibody (C-term)
...
http://www.abgent.com/products/category/nuclear_signaling/tr...

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Transcription Regulator Antibodies
HARS Antibody / HARS Antibodies · HAT1 Antibody / HAT1 Antibodies · HBO1 Antibody / HBO1 Antibodies · HBP1 Antibody / HBP1 Antibodies ...
http://www.scbt.com/chapter_transcription_regulator_antibodi...

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Abcam antibodies and reagents product map
... Glucose 6 phosphate isomerase antibodies (5) · Graves disease carrier protein / GDC antibodies (2) · HARS antibodies (5) · HARS proteins and peptides
(1 ...
http://www.abcam.com/index.html?pageconfig=productmap&cl=249...

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HisRS (HARSA6) Antibody sc-81287
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, HARS, 3035, 5q31.3, NM_002109 ...
http://www.scbt.com/datasheet-81287-hisrs-harsa6-antibody.ht...

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Abcam antibodies and reagents product map
... FARSLA antibodies (3) · FARSLB antibodies (1) · Glutamyl Prolyl tRNA synthetase antibodies (3) · HARS antibodies (5) · HARS proteins and peptides (1)
...
http://www.abcam.com/index.html?c=250...

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