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HAS2


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Gene DB Home
Symbol:HAS2
Name(s):hyaluronan synthase 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC126241, MGC126242
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17872502 HAS2 plays an important role in regulating hyaluronan synthesis and human embryonic stem cell differentiation.
17611197 Interleukin-1beta stimulation resulted in induction of HAS1 and HAS2 transcription but did not induce phenotypic differentiation or induce hyaluronan coat assembly
15922739 Antisense inhibition of HAS2 in osteosarcoma cells inhibits hyaluronan retention and tumorigenicity.
16807238 osteopontin-transfected cells express high levels of hyaluronan synthase 2, which is associated with increased HA production and matrix retention and is necessary for tumor cell adhesion to bone marrow endothelial cells and anchorage-independent growth
14636845 Expression of each hyaluronan synthase isoform is regulated differently by growth factors and cytokines in vascular endothelial cells. Expressed in proliferative membranes from proliferative vitreoretinal diseases. May affect progression of diseases.
14752026 Upregulation of HAS2 expression via EP(2) and IP receptors might contribute to the accumulation of HA during human atherosclerosis, thereby mediating proatherosclerotic functions of COX2.
11790779 hyaluronan synthase expression in prostate adenocarcinoma cells
15677552 IL-1beta induction of HAS2 expression involves multiple signaling pathways that act in concert, thus leading to an increase in expression of hyaluronan by jejunum-derived mesenchymal cells
16687630 hyaluronan synthase 2 and TSG-6 have roles in hyaluronan distribution and function in proximal tubular epithelial cells
16786194 The aim of this study was to evaluate how TNF-alpha, IFN-gamma,IL-1beta, and exposition to oxidative stress may modulate HAS activities in normal human skin fibroblasts.

View more information from publications.

Recent Publications on HAS2:

Pubmed Logo
Early requirement of Hyaluronan for tail regeneration in Xenopus tadpoles.
Tail regeneration in Xenopus tadpoles is a favorable model system to...
3rd November, 2009
Center for Aging and Regeneration, Center for Cell Regulation and Development. 2009 Sep;136(17):2987-96.
DOI Direct Link
Mycobacteria exploit host hyaluronan for efficient extracellular replication.
In spite of the importance of hyaluronan in host protection against...
31st October, 2009
Department of Bacteriology, Osaka City University Graduate School of PLoS Pathog. 2009 Oct;5(10):e1000643. Epub 2009 Oct 30.
DOI Direct Link
Novel gene rearrangements in transformed breast cells identified by high-resolution breakpoint analysis of chromosomal aberrations.
Chromosomal copy number alterations and chromosomal rearrangements are...
28th October, 2009
K Unger, Department of Histopathology, Imperial College London, London, Endocr Relat Cancer. 2009 Oct 26.
DOI Direct Link
Increased cAMP levels modulate transforming growth factor(TGF-{beta})/SMAD-induced expression of extracellular matrix components and other key fibroblast effector functions.
cAMP is a key messenger of a variety of hormones and neuropeptides some of...
28th October, 2009
Dept. of Dermatology and Ludwig Boltzmann Institute for Cell Biology and J Biol Chem. 2009 Oct 26.
DOI Direct Link
T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgf{beta}2 expression and endocardial cushion formation.
During early heart development, Tbx2 gene expression is initiated in the...
23rd October, 2009
Department of Bioscience, National Cardiovascular Center Research Proc Natl Acad Sci U S A. 2009 Oct 21.
DOI Direct Link

View more research publications.

Press Releases on HAS2:

BioPortfolio Logo
MEDITECH SHOWCASES CANCER RESEARCH TO INTERNATIONAL AUDIENCE 1st October, 2004 Meditech

MEDITECH SHOWCASES CANCER RESEARCH TO INTERNATIONAL AUDIENCE

Clinical Trials:

Clinical Trials Logo
Safety Study of AMG 386 to Treat HER2-positive Locally Recurrent or Metastatic Breast Cancer

Patents:

Patents logo
US Patent No.Title
5815385 Control of an installation for transmission of high-voltage direct current
6680174 Assay for growth differentiation factor 9
6682904 Specific inhibitors of hyaluronidase 2, and methods of identifying and using same
6833264 Hyaluronan synthase gene and uses therof
6884619 Inhibition of BEHAB cleavage and primary central nervous system (CNS) tumors

View more patents.

HAS2 results (if any) from reagent suppliers

Google CSE Logo
HAS2 (Y-14) Antibody sc-34068
HAS2 siRNA shRNA (h) Lentiviral Particles, sc-45328-V, 200 µl ... Western blot analysis of HAS2 expression in mouse embryo tissue extract. Download ...
http://www.scbt.com/datasheet-34068-has2-y-14-antibody.html...

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Hyaluronan synthase 1 antibody (ab75329) | Abcam
HA is synthesized by membrane-bound HA synthases (HAS1, HAS2 and HAS3) at the inner surface of the plasma membrane. The three HAS genes show distinct ...
http://www.abcam.com/Hyaluronan-synthase-1-antibody-ab75329....

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HAS Antibody / HAS Antibodies
HAS2 (S-15) Antibody, sc-34067, goat IgG, cytoplasmic (h), WB, IF, ELISA, m, r, h, cow. HAS2 (Y-14) Antibody, sc-34068, goat IgG, C-terminal (h), WB, IP, ...
http://www.scbt.com/table-has.html...

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Search Results
Stock# - 007226 Strain name - B6;129P2-Has2/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/007226.html - 29Kb ...
http://www.jax.org/search/Main.jsp?sg=4&qt=retardation&page=...

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HAS2 siRNA (h) sc-45328
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: HAS2 (h)-PR: sc-45328-PR, 20 µl ...
http://www.scbt.com/ja/datasheet-45328-has2-sirna-h.html...

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HAS2 (Y-14) Antibody sc-34068
HAS2 (Y-14) 抗体 sc-34068 HAS2 (Y-14) Antibody sc-34068.
http://www.scbt.com/ja/datasheet-34068-has2-y-14-antibody.ht...

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