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HBA2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 11154980 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17996867 |
Our study suggests that the regulation of alpha-URE and beta-LCR on the expression level and developmental switching mode of downstream globin genes is cluster specific. |
| 17715390 |
mechanism by which the human globin genes are activated during erythropoiesis |
| 17920577 |
In alpha-thalassemia, alpha/beta-globin mRNA ratio correlated with the number of functional alpha-globin genes present, whereas in beta-thalassemia, the ratio provided a good indicator of disease severity. |
| 17589844 |
multiple origins of the alpha(CS) and a single origin of the alpha(Pakse) mutations in Southeast Asia |
| 17587614 |
interaction of the Hb Constant Spring EE Bart's disease produces a tetrameric Hb molecule is formed between alpha(CS) and beta(E) chains leading to a hybrid Hb |
| 11836160 |
Hb Pakse differs from Hb CS by having lysine at 142 instead of glutamine. It also seems to lead to an unstable alpha globin mRNA and slighter higher Hb H levels. |
| 12673836 |
Review. The effects of alpha-globin genotype on the pathophysiology of sickle cell anemia, HbSC disease, and sickle beta-thalassemia are studied. |
| 16798639 |
Hb Al-Hammadi Riyadh [codon 75 (GAC-->GTC); alpha75(EF4)Asp-->Val (alpha2)] corresponds to an A-->T transversion in the second exon of the alpha2-globin gene. |
| 12659864 |
Crystallization and X-ray structure of this protein, isolated from blood of beta-thalassemic patients. | →View more information from publications. |
Recent Publications on HBA2: |  |
Signatures of high-altitude adaptation in the major hemoglobin of five species of andean dabbling ducks.
Hypoxia is one of the most important factors affecting survival at high... | 1st October, 2009
| Institute of Arctic Biology, Department of Biology and Wildlife, and
| Am Nat. 2009 Nov;174(5):631-50.
DOI Direct Link |
Hb Southern Italy: coexistence of two missence mutations (the Hb Sun Prairie alpha2 130 Ala > Pro and Hb Caserta alpha2 26 Ala > Thr) in a single HBA2 gene.
OBJECTIVE: To evaluate sensitivity, specificity, and positive and negative... | 11th September, 2009
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| Br J Haematol. 2009 Jun;145(6):843-4. Epub 2009 Mar 31.
DOI Direct Link |
Novel human pathological mutations. Gene symbol: HBA2. Disease: Thalassemia alpha.
BACKGROUND: Hemoglobin (Hb) S-beta(+)-thalassemia is a relatively mild... | 9th September, 2009
| Internal Medicine, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e
| Hum Genet. 2009 Aug;126(2):342.
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Falsely elevated hemoglobin A1c due to S-beta+-thalassemia interference in Bio-Rad Variant II Turbo HbA1c assay.
BACKGROUND: Hemoglobin (Hb) S-beta(+)-thalassemia is a relatively mild... | 25th August, 2009
| Department of Pathology and Laboratory Medicine, Medical University of
| Clin Chim Acta. 2009 Nov;409(1-2):18-20. Epub 2009 Aug 19.
DOI Direct Link |
Genome-wide screen of genes required for caffeine tolerance in fission yeast.
BACKGROUND: An excess of caffeine is cytotoxic to all eukaryotic cell... | 13th August, 2009
| Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra,
| PLoS One. 2009 Aug 12;4(8):e6619.
DOI Direct Link |
→View more research publications. |
HBA2 results (if any) from reagent suppliers | 
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Hemoglobin antibody, Hemoglobin [901] Antibody, Mouse Monoclonal ...
Disease: Defects in HBA1/HBA2 may be a cause of Heinz body anemias [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of Dacie type 1. ...
http://www.genwaybio.com/product_info.php?products_id=193038...
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Hemoglobin α (V-13) Antibody sc-31109
Human, HBA2, 3040, 16p13.3, NM_000517 · P69905 · 141850. Mouse, Hba-a1, 15122, 11 A4, P01942, N/A. Mouse, Hba-a2, 110257, 11 A4, NP_001077424 ...
http://www.scbt.com/datasheet-31109-hemoglobin-alpha-v-13-an...
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Chicken egg yolk antibodies specific for the gamma chain of human ...
... plus Portland) and to a lesser degree with beta globin, Hb A, Hb A2 and adult hemolysate (Hbs A plus A2), but the Abs did not react with alpha globin.
...
http://www.gallusimmunotech.com/Chicken_egg_yolk_antibodies_...
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Hemoglobin α/β/γ (PBH1) Antibody sc-58269
... α/β/γ of human origin by IF and FCM; also recommended for detection of all forms of human hemoglobin, including HbA, HBA2, HBA1C, HbF, HbS, and HbE ...
http://www.scbt.com/datasheet-58269-hemoglobin-alpha-beta-ga...
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Native Proteins - GenWay Biotech Inc.
HBA1; HBA2 - NATIVE BOVINE HEMOGLOBIN; Hemoglobin subunit alpha, Native Protein ELISA, Source: N/A Reactivity: Bovine ...
http://www.genwaybio.com/all_native_proteins.php?fl=H...
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Hemoglobin α siRNA (h) sc-41230
Human, HBA2, 3040, 16p13.3, NM_000517 · P69905 · 141850. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. Hemoglobin α siRNA (h) ...
http://www.scbt.com/datasheet-41230-hemoglobin-alpha-sirna-h...
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From 0 to 50 µg in 2 hours flat. From 0 to 50 µg in 2 hours flat.
30 seconds, 68°C for one minute). Progressive # of primer sets. M1 2 3 4 5 6 7 8 9 1011121314151617181920M. Tsm1-44 bp. Thal-57 bp. Hba2-67 bp. Rgr-74 bp ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf/ex...
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