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HBE1


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Gene DB Home
Symbol:HBE1
Name(s):hemoglobin, epsilon 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:HBE
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11132230 Observational study of genotype prevalence. (HuGE Navigator)
11304851 Observational study of genetic testing. (HuGE Navigator)
17548470 The epsilon-globin gene differs in its distance sensitivity to the locus control region from the other beta-like globin genes, which is, at least in part, determined by the transcription factor EKLF.
17003365 The epsilon-globin mRNA is modestly unstable in immature, transcriptionally active erythroid cells, but that this characteristic has relatively little impact on the accumulation of epsilon-globin mRNA at subsequent stages of terminal differentiation.
12659864 Crystallization and X-ray structure of this protein, isolated from blood of beta-thalassemic patients
15449937 The crystal structure of HbE at 1.74 angstrom resolution in R2 state is used to provide probable explanations of the thermal stability and instability of HbE.
15157738 Genomic and phylogenetic footprinting at the epsilon-globin silencer region in human cells
16432873 Mutation screening identified no sequence variations apart from the expected 5'epsilon /HincII polymorphism, suggesting that genomic alterations in the HBE1 gene are most likely incompatible with normal erythropoiesis and proper embryonic development
15114532 HbE carrier status has been shown to confer protection against Plasmodium falciparum malaria
16620781 We discussed these results in the context of intergenic transcription and chromatin opening in the beta-globin gene cluster.

View more information from publications.

Recent Publications on HBE1:

Pubmed Logo
Regulation of Airway MUC5AC Expression by IL-1{beta} and IL-17A; the NF-{kappa}B Paradigm.
Mucin over-production is one of the hallmarks of chronic airway diseases...
21st October, 2009
Center of Comparative Respiratory Biology and Medicine, University of J Immunol. 2009 Oct 19.
DOI Direct Link
Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes.
Phase II enzymes are induced primarily through the common electrophile...
20th October, 2009
School of Natural Science, University of California at Merced, Merced, CA Toxicol Ind Health. 2009 May-Jun;25(4-5):269-78.
DOI Direct Link
Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma.
Multidrug-resistant proteins (MRPs) are members of the ATP-binding...
18th September, 2009
Department of Natural Sciences, University of California at Merced, Free Radic Biol Med. 2009 Jun 15;46(12):1650-7. Epub 2009 Apr 5.
DOI Direct Link
The role of c-Jun phosphorylation in EpRE activation of phase II genes.
The transcription factors that bind to EpRE's play a key role in the...
12th August, 2009
School of Natural Sciences, University of California at Merced, Merced, CA Free Radic Biol Med. 2009 Oct 15;47(8):1172-9. Epub 2009 Aug 7.
DOI Direct Link
A clinically relevant in vitro model for evaluating the effects of aerosolized vesicants.
The chemical warfare vesicant sulfur mustard (HD) is a known toxic agent...
1st April, 2009
Department of Pathology, Uniformed Services University of the Health Toxicol Lett. 2009 Feb 25;185(1):38-44. Epub 2008 Dec 3.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
5408636 System for flushing first and second caches upon detection of a write operation to write protected areas
5424191 Epithelial cell specific differentiation marker
5448742 Method and apparatus for local memory and system bus refreshing with single-port memory controller and rotating arbitration priority
5521291 Conjugates for introducing nucleic acid into higher eucaryotic cells

View more patents.

HBE1 results (if any) from reagent suppliers

Google CSE Logo
Hepatitis B Virus e antigen, antibody
IgG2b for MAbs AC5, HBe1, HBe2, HBe3, HBe5, HBe8, HBe9 and HBe10 IgG3 for MAb HBe6. Applications: Detection of HBeAg. Recommended pairs for sandwich ...
http://www.hytest.fi/product/hepatitis-b-virus-e-antigen,-an...

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Hemoglobin ε siRNA (h) sc-105450
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, HBE1, 3046, 11p15.4, NM_005330 ...
http://www.scbt.com/ko/datasheet-105450-hemoglobin-epsilon-s...

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H7379 Hemoglobin human Hb lyophilized powder
HBA1(3039), HBA2(3040), HBB(3043), HBD(3045), HBE1(3046), HBG1(3047), HBG2(3048) , HBQ1(3049), HBZ(3050). storage temp. 2-8°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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General Product Catalog 2009-2010
3HBe24 HBe1. IgG2b. EIA. Hepatitis B Virus “e” Antigen. 3HBe24 HBe2. IgG2b. EIA. Hepatitis B Virus “e” Antigen. 3HBe24 HBe3. IgG2b. EIA (detection) ...
http://www.hytest.fi/data_sheets/General%20Product%20Catalog...

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Chromosome 11- Santa Cruz Biotechnology, Inc.
HBE1 · 3046, 11p15.4, P02100 · Hemoglobin ε · sc-105450 · NM_005330, n/a. OR51B4 · 79339, 11p15.4, Q9Y5P0 · OR51B4 · sc-96724 · NM_033179, n/a ...
http://www.scbt.com/ja/chromosome.php?number=11&page=4&speci...

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