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HBG2


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Gene DB Home
Symbol:HBG2
Name(s):hemoglobin, gamma G
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18266208 Observational study of gene-disease association. (HuGE Navigator)
11132233 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16956833 Observational study of gene-disease association. (HuGE Navigator)
15798211 3' flank of the Ggamma-globin gene contains multiple weak pause elements which, combined with the strong polyA signal the gene possesses, are likely to cause gradual termination across the 3' flank.
11827978 Assembly of human hemoglobin (Hb) beta- and gamma-globin chains expressed in a cell-free system with alpha-globin chains to form Hb A and Hb F.
14649320 in an Albanian family, two mutations of the gamma-globin promoter (for both HBG1 and HBG2) are assoicated in trans with a beta thal point mutation, that results in increased levels of HbF
17365007 A determinant linked to the XmnI restriction site which effects Ggamma-globin gene expression (and Hemoglobin F production) is active in beta-Thalassemic (anemic) adults but not in normal infants.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDG-gamma globinG-gamma globin--Pubmed

Recent Publications on HBG2:

Pubmed Logo
Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.
Increased levels of fetal hemoglobin (HbF, alpha(2)gamma(2)) are of no...
8th October, 2009
Division of Gene and Cell Based Therapy, King's College London School of Hum Mol Genet. 2009 Oct 15;18(R2):R216-23.
DOI Direct Link
Multiplex ligation-dependent probe amplification screening of isolated increased HbF levels revealed three cases of novel rearrangements/deletions in the beta-globin gene cluster.
Summary Investigations of naturally occurring mutations, such as the...
8th October, 2009
Department of Laboratory Medicine and Genetics, Samsung Medical Centre, Br J Haematol. 2009 Oct 5.
DOI Direct Link
The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.
Nondeletional hereditary persistence of fetal hemoglobin (nd-HPFH), a rare...
25th July, 2009
Department of Biology, School of Medicine, University of Thessaly, Ann Hematol. 2009 Jun;88(6):549-55. Epub 2008 Dec 3.
DOI Direct Link
Discovering the genetics underlying foetal haemoglobin production in adults.
Sickle cell disease (SCD) and beta thalassaemia, caused by lesions that...
1st July, 2009
King's College London School of Medicine, Molecular Haematology, Division Br J Haematol. 2009 May;145(4):455-67. Epub 2008 Mar 2.
DOI Direct Link
Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin.
High levels of fetal haemoglobin (HbF) are protective in...
27th May, 2009
Division of Gene and Cell Based Therapy, King's College London School of Br J Haematol. 2009 Mar;144(6):954-60. Epub 2008 Dec 20.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
7608395 Systemic lupus erythematosus diagnostic assay
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7291461 Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay

View more patents.

HBG2 results (if any) from reagent suppliers

Google CSE Logo
F hemoglobin antibody, F hemoglobin antibody (FITC) Antibody ...
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver , spleen and bone marrow. Two gamma chains together with two alpha chains ...
http://www.genwaybio.com/product_info.php?products_id=196767...

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Hemoglobin γ (51-7) Antibody sc-21756
Human, HBG2, 3048, 11p15.4, NM_000184 · P69892 · 142250. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. Hemoglobin γ (51-7) ...
http://www.scbt.com/datasheet-21756-hemoglobin-gamma-51-7-an...

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H7379 Hemoglobin human Hb lyophilized powder
HBA1(3039), HBA2(3040), HBB(3043), HBD(3045), HBE1(3046), HBG1(3047), HBG2(3048) , HBQ1(3049), HBZ(3050). storage temp. 2-8°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Hemoglobin γ siRNA (h) sc-37108
Human, HBG2, 3048, 11p15.4, NM_000184 · P69892 · 142250. 주문정보. 제품명, 카탈로그 번호, 단위, 가격, 수량, 관심상품. Hemoglobin γ siRNA (h), sc-37108 ...
http://www.scbt.com/ko/datasheet-37108-hemoglobin-gamma-sirn...

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Hemoglobin γ (51-7) Antibody sc-21756
人类, HBG2, 3048, 11p15.4, NM_000184 · P69892 · 142250. 订购信息. 产品名称, 产品 编号, 规格, 价格, 数量, 欲购列单. Hemoglobin γ (51-7), sc-21756, 200 µg/ml ...
http://www.scbt.com/zh/datasheet-21756-hemoglobin-gamma-51-7...

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Hemoglobin γ (51-7) Antibody sc-21756
Human, HBG2, 3048, 11p15.4, NM_000184 · P69892 · 142250. Informazioni ordini. Nome del prodotto, Codice del prodotto, Unità, Prezzo, Quantità ...
http://www.scbt.com/it/datasheet-21756-hemoglobin-gamma-51-7...

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