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HBZ


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Gene DB Home
Symbol:HBZ
Name(s):hemoglobin, zeta
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15755797 The HBZ protein is localized to heterochromatin and capable of repressing JUN activity and viral transcription.
11747442 Chimeric zeta globin exhibits oxygen binding characteristics which fall within the range observed in adult human and human embryonic hemoglobins.
15555579 Hb zeta(2)beta(2)(S) exhibits an O(2) affinity as well as a Hill coefficient, Bohr response, and allosteric properties in vitro that are suboptimally suited for physiological O(2) transport in vivo

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDHemoglobin beta chainzeta globin--Pubmed
HPRDbeta globinHemoglobin zeta--Pubmed
HPRDzeta globinzeta globin--Pubmed

Recent Publications on HBZ:

Pubmed Logo
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription.
Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2)...
23rd October, 2009
Departement des Sciences Biologiques et Centre de recherche BioMed, Blood. 2009 Sep 17;114(12):2427-38. Epub 2009 Jul 14.
DOI Direct Link
The HBZ gene, a key player in HTLV-1 pathogenesis.
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell...
17th October, 2009
Laboratory of Virus Control, Institute for Virus Research, Kyoto Retrovirology. 2009 Aug 3;6:71.
DOI Direct Link
HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes.
Recently, HBZ has been reported to play an important role in the...
2nd September, 2009
Department of Bioregulatory Medicine, Ehime University Graduate School of J Gen Virol. 2009 Aug;90(Pt 8):1806-11. Epub 2009 May 7.
DOI Direct Link
Propensity for HBZ-SP1 isoform of HTLV-I to inhibit c-Jun activity correlates with sequestration of c-Jun into nuclear bodies rather than inhibition of its DNA-binding activity.
HTLV-I bZIP factor (HBZ) contains a C-terminal zipper domain involved in...
1st September, 2009
Universite Montpellier 1, Centre d'etudes d'agents Pathogenes et Virology. 2009 Sep 1;391(2):195-202. Epub 2009 Jul 12.
DOI Direct Link
Dynamic extended folding: modeling the RNA secondary structures during co-transcriptional folding.
For RNA secondary structure prediction, it is an important issue that how...
1st August, 2009
Modern Biological Research Center, Yunnan University, Kunming 650091, J Theor Biol. 2009 Nov 7;261(1):93-9. Epub 2009 Jul 28.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Comparison of Safety and Efficacy of Two Different Drug Eluting Stents Implanted Into Saphenous Vein Grafts

Patents:

Patents logo
US Patent No.Title
4093313 Two-circuit brake system for motor vehicles
5445443 Motorcycle ABS using horizontal and vertical acceleration sensors
5445444 Automatic braking procedure for motor vehicles with an ABS
5618088 Anti-lock control system
6037324 Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor

View more patents.

HBZ results (if any) from reagent suppliers

Google CSE Logo
3C-3E
Monoclonal Anti-HBZ antibody produced in mouse clone 3C4-1D5, purified immunoglobulin, buffered aqueous solution, 3C4-1D5 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

Thumbshot
Hemoglobin ζ siRNA (h) sc-105449
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, HBZ, 3050, 16p13.3, NM_005332 ...
http://www.scbt.com/datasheet-105449-hemoglobin-zeta-sirna-h...

Thumbshot
Many possibilities. One way forward.
GCM1, GFAP, HBB, HBZ, HLXB9, IAPP,. INS, IPF1, ISL1, KRT1, LAMA1, LAMB1,. LAMC1, MYF5, MYOD1, NES, NEUROD1,. NPPA, OLIG-2, PAX4, PAX6, PECAM1, ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/Cell-C...

Thumbshot
Hemoglobin ζ (C-1B3) Antibody sc-101272
... Numéro d'accès d´isoforme d´ARNm, Numéro d'accès de la protéine, Numéro OMIM ™. Humain, HBZ, 3050, 16p13.3, NM_005332 · P02008 ...
http://www.scbt.com/fr/datasheet-101272-hemoglobin-zeta-c-1b...

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Abcam antibodies and reagents product map
... Glycophorin C antibodies (5) · HBZ antibodies (2) · HEBP1 antibodies (1) · HLA DM antibodies (2) · HLA DQ3 antibodies (1) · HLA DR beta antibodies (3) ...
http://www.abcam.com/index.html?c=253...

Thumbshot
Hemoglobin ζ (C-1B3) Antibody sc-101272
... Numero de Accesion de Isoforma (ARNm), Numero de Accesion de la Proteina, Número de pedido: Humano, HBZ, 3050, 16p13.3, NM_005332 · P02008 ...
http://www.scbt.com/es/datasheet-101272-hemoglobin-zeta-c-1b...

Thumbshot
Hemoglobin ζ (C-1B3) Antibody sc-101272
... Numero de acesso de isoformas de RNA mensageiro, Numero de acesso de proteina, OMIM&trande; Numero. Humano, HBZ, 3050, 16p13.3, NM_005332 · P02008
...
http://www.scbt.com/pt/datasheet-101272-hemoglobin-zeta-c-1b...

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