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HCFC1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17578910 |
HCF-1 was required for recruitment of the histone methyltransferases Set1 and MLL1, leading to histone H3K4 trimethylation and transcriptional activation. |
| 16042417 |
The fibronectin domain of HCF interacts with HCF in the herpes simplex virus VP16-induced transcriptional activating complex, an association requiring a region outside the putative HCF beta-propeller fold |
| 12743030 |
These results suggest that host cell factor-1 (HCF-1) links the regulation of exit from mitosis and the G(1) phase of cell growth, possibly to coordinate the reactivation of gene expression after mitosis. |
| 12235138 |
HCF-1 activity is regulated by HPIP by modulating its subcellular localization |
| 14532282 |
Three proteins found to contain the HCF-binding motif were further analyzed for their ability to use HCF-1 as a coactivator. Krox20 and E2F4 showed a strong requirement for HCF-1 to activate activation transcription, while estrogen receptor-alpha did not. |
| 17612494 |
During the G1-to-S phase transition, HCF-1 recruits the mixed-lineage leukemia (MLL) and Set-1 histone H3 lysine 4 methyltransferases to E2F-responsive promoters and induces histone methylation and transcriptional activation. |
| 12271126 |
HCF-1 contains an activation domain (HCF-1(AD)) required for maximal transactivation by VP16 and its cellular counterpart LZIP. |
| 12670868 |
The results presented in this paper suggest that HCF-1 can broadly regulate transcription, both positively and negatively, through selective modulation of chromatin structure. |
| 15931389 |
Altered expression is associated with therapy failure and death in patients with multiple types of cancer. |
Recent Publications on HCFC1: |  |
Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.
NRC/NCoA6 plays an important role in mediating the effects of ligand-bound... | 15th May, 2009
| Department of Pharmacology, New York University School of Medicine, New
| J Biol Chem. 2009 Mar 20;284(12):7542-52. Epub 2009 Jan 8.
DOI Direct Link |
Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1.
Protein ubiquitination provides an efficient and reversible mechanism to... | 23rd April, 2009
| Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South
| Mol Cell Biol. 2009 Apr;29(8):2181-92. Epub 2009 Feb 2.
DOI Direct Link |
Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension.
Epidermal Growth Factor-Cripto-1/FRL-1/Cryptic (EGF-CFC) proteins,... | 7th February, 2009
| Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory,
| Biochim Biophys Acta. 2008 Dec;1778(12):2671-81. Epub 2008 Oct 1.
DOI Direct Link |
Association of the cellular coactivator HCF-1 with the Golgi apparatus in sensory neurons.
HCF-1 is a cellular transcriptional coactivator that is critical for... | 10th October, 2008
| National Institutes of Health, 4-129, 4 Center Drive, Bethesda, MD 20892,
| J Virol. 2008 Oct;82(19):9555-63. Epub 2008 Jul 30.
DOI Direct Link |
Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.
BACKGROUND: The human herpes simplex virus (HSV) host cell factor HCF-1 is... | 22nd August, 2008
| Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States
| PLoS One. 2007 Nov 28;2(11):e1213.
DOI Direct Link |
→View more research publications. |
HCFC1 results (if any) from reagent suppliers | 
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Zhangfei antibody (ab28700) | Abcam
Zhangfei strongly activates transcription when bound to HCFC1. It suppresses the expression of HSV proteins in cells infected with the virus in a HCFC...
http://www.abcam.com/Zhangfei-antibody-ab28700.html...
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HCF1 Antibody Bethyl Laboratories
Alternate Names, HCF1, HCF-1, HCFC1, HFC1, HF1, host cell factor C1, VCAF. ... Alternate names for HCF1 include host cell factor, HCF, HCFC1, C1 factor, ...
http://www.bethyl.com/go/?product/A301-400A...
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HDAC2 peptide, HDAC2 (Ab-394) Antibody Blocking Peptide peptide
Interacts with ATR, DNMT1, MINT, HDAC7, HDAC10, HCFC1, NRIP1, MJD2A/JHDM3A, SAP30, SETDB1 and SUV39H1. Interacts with the non-histone region of H2AFY. ...
http://www.genwaybio.com/product_info.php?products_id=213340...
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HCF1 (D-20) Antibody sc-13429
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, HCFC1, 3054, Xq28, NM_005334 ...
http://www.scbt.com/ko/datasheet-13429-hcf1-d-20-antibody.ht...
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CFH antibody, FACTOR H Antibody, Mouse Monoclonal Antibody
HCFC1 (host cell factor C1 (VP16-accessory protein)), IgG · HFH4 [MA5-3-19], IgG Native_Protein. FACTOR H, Native_Protein · Translin, Protein ...
http://www.genwaybio.com/product_info.php?products_id=75016...
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HCF1/2 (C-19) Antibody sc-13432
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, HCFC1, 3054, Xq28, NM_005334 · P51610
...
http://www.scbt.com/ja/datasheet-13432-hcf1-2-c-19-antibody....
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EGR2 antibody, EGR2 (early growth response 2 (Krox-20 homolog ...
Subunit: Interacts with HCFC1. Subcellular Location: Nucleus. Disease: Defects in EGR2 are a cause of congenital hypomyelination neuropathy (CHN) ...
http://www.genwaybio.com/product_info.php?products_id=43032...
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