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HCK
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17024369 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17893228 |
Nef perturbs the intracellular maturation and the trafficking of nascent Fms, through a unique mechanism that required both the activation of Hck and the aberrant spatial regulation of the active Hck |
| 17668209 |
hematopoietic cell kinase (hct) phosphorylates fems-like tyrosine kinase 3(FLT3) in the JM region and inhibits its maturation |
| 14969582 |
SRC kinases LYN & HCK let engaged b2 integrins form focal-adhesion-like structures needed for stable shear-resistant PMN adhesion. SRC-dependent outside-in signalling is needed for integrin adhesiveness triggered by a classical chemoattractant like IL-8. |
| 12592324 |
The interaction of the Bcr-Abl tyrosine kinase with this protein is mediated by multiple binding domains. |
| 15626739 |
HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and thereby inhibits M-CSF functions in monocytes/macrophages. |
| 15010462 |
Gab2 docking proteins in IL-6-induced proliferation and survival of multiple myeloma cells. |
| 11976726 |
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo |
| 14551197 |
C3G and Hck interact physically and functionally in vivo to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G |
| 16210316 |
data support the existence of multiple active conformations of Src family member Hck kinase that may generate unique downstream signals | →View more information from publications. |
Recent Publications on HCK: |  |
Reengineering the Signaling Properties of a Src Family Kinase.
Src family kinases (SFKs) are modular signaling proteins possessing SH3,... | 16th October, 2009
| Department of Physiology and Biophysics, School of Medicine, Stony Brook
| Biochemistry. 2009 Oct 28.
DOI Direct Link |
Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.
Multiple Src family kinases (SFKs) are present in murine embryonic stem... | 15th October, 2009
| University of Pittsburgh School of Medicine, Department of Microbiology
| Sci Signal. 2009 Oct 13;2(92):ra64.
DOI Direct Link |
Chemical Library Screens Targeting an HIV-1 Accessory Factor/Host Cell Kinase Complex Identify Novel Antiretroviral Compounds.
Nef is an HIV-1 accessory protein essential for AIDS progression and an... | 8th October, 2009
| Department of Microbiology and Molecular Genetics, University of
| ACS Chem Biol. 2009 Oct 27.
DOI Direct Link |
Identification of protein tyrosine kinases with oncogenic potential using a retroviral insertion mutagenesis screen.
Protein tyrosine kinases form a large family of signaling proteins... | 2nd October, 2009
| Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium.
| Haematologica. 2009 Oct;94(10):1440-4.
DOI Direct Link |
Comparison of intravesical botulinum toxin type A injections plus hydrodistention with hydrodistention alone for the treatment of refractory interstitial cystitis/painful bladder syndrome.
OBJECTIVE: To compare the clinical effectiveness of botulinum toxin type A... | 29th September, 2009
| Department of Urology, Buddhist Tzu Chi General Hospital, and Tzu Chi
| BJU Int. 2009 Sep;104(5):657-61. Epub 2009 Mar 30.
DOI Direct Link |
→View more research publications. |
HCK results (if any) from reagent suppliers | 
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