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Symbol:HK2
Name(s):hexokinase 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp686M1669, HKII, HXK2
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17785433 HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2 and pyruvate dehydrogenase kinase 1.
15710218 Hexokinase II induction may participate in hepatocellular carcinoma progrssion and the blockage of this enzyme may therapeutically be efficacious.
15967114 Glut-1, HK-II, and PCNA expression are related to uptake of 18F-FDG uptake in lung cancer
14747281 SRE binding protein-1c is involved in the effect of insulin on HKII gene transcription.
14672622 Both HIF-1 alpha and HK II protein expressions were co-localized in the cancer cells near necrosis, and the intensity of HIF-1 alpha protein expression was significantly correlated with HK II mRNA expression in both tumors.
11688991 hypoxia-induced gene in pancreatic cancer cell lines
16551620 cyclophilin D suppresses apoptotic cell death via a mitochondrial hexokinase II-dependent mechanism in cancer cells

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDhexokinase 2prostaglandin H2 D-isomeraseHKII interacts with PGDS. This interaction was modeled on a demonstrated interaction between rat HKII and human PGDS.-Pubmed
BINDhexokinase 2insulin-like growth factor binding protein 4HKII interacts with IGFBP-4. This interaction was modeled on a demonstrated interaction between rat HKII and human IGFBP-4.-Pubmed
BINDhexokinase 2zinc finger and BTB domain containing 17HKII interacts with Miz-1. This interaction was modeled on a demonstrated interaction between rat HKII and human Miz-1.-Pubmed

Recent Publications on HK2:

Pubmed Logo
Endostatin, an antiangiogenic protein, is expressed in the unilateral ureteral obstruction mice model.
Background: Extracellular matrix accumulation, epithelial-to-mesenchymal...
25th October, 2008
Nephrology Division, Federal University of Sao Paulo, Sao Paulo - Brazil. J Nephrol. 2008 Sep-Oct;21(5):753-60.
The MIF Receptor CD74 in Diabetic Podocyte Injury.
Although metabolic derangement plays a central role in diabetic...
10th October, 2008
*Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Fundacion Renal J Am Soc Nephrol. 2008 Oct 8.
DOI Direct Link
Development of peptides specifically modulating the activity of KLK2 and KLK3.
The prostate produces several proteases, the most abundant ones being...
27th September, 2008
Department of Clinical Chemistry, Biomedicum Helsinki, University of Biol Chem. 2008 Jun;389(6):633-42.
DOI Direct Link
The interplay between MYC and HIF in the Warburg effect.
c-MYC and the hypoxia-inducible factors (HIFs) are critical factors for...
25th September, 2008
Department of Medicine, Cell Biology, Molecular Biology and Genetics, Ernst Schering Found Symp Proc. 2007;(4):35-53.
Biomarkers associated with breast cancer are associated with obesity.
BACKGROUND: Obesity is linked to the development of postmenopausal breast...
10th September, 2008
Department of Surgery, University of Missouri, One Hospital Drive, Cancer Detect Prev. 2008;32(2):149-55. Epub 2008 Jul 17.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
A Survey to Evaluate the Cardiovascular Risk Status of Subjects With Pre-Diabetes in Hong Kong
Prediabetes;   Cardiovascular Risk Factors

Patents:

Patents logo
US Patent No.Title
7179901 Renal regulatory elements and methods of use thereof
7247473 Motor proteins and methods for their use
7251568 Methods and compositions for regulating bone and cartilage formation
7255997 Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
7258977 Process for typing of HCV isolates

View more patents.

HK2 results (if any) from reagent suppliers

Google CSE Logo
H2165 Anti HK2 416 429 antibody produced in rabbit IgG fraction of ...
H2165 Anti-HK2 (416-429) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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HK2 Antibody (N-term)
"In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme ...
http://www.abgent.com/products/catalog_no/AP8140a...

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HK2 hexokinase 2
HK2; DKFZP686M1669; HKII; HXK2. Other Designations. hexokinase-2, muscle ... H2165, Anti-HK2 (416-429) antibody produced in rabbit IgG fraction of antiserum
...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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HK2 Antibody (N-term) Blocking Peptide
The synthetic peptide sequence used to generate the antibody AP8140d was selected from the N-term region of human HK2 . A 10 to 100 fold molar excess to
...
http://www.abgent.com/products/catalog_no/BP8140d...

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Antibodies to Oxidative Stress Proteins
H2165, Anti-HK2 (416-429) antibody produced in rabbit New, IgG fraction of antiserum, human ... HK2(3099), human, WB. N5288, Anti-NQO1 (C-terminal)
antibody ...
http://www.sigmaaldrich.com/catalog/search/TablePage/1383332...

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HK2 Antibody (Center) Blocking Peptide
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/products/catalog_no/BP8140f...

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KIF2A Antibody AbVantage Pack
Anti-KIF2A Antibody, Anti-KIF-2A Antibody, Anti-HK2 Antibody, Anti-. KIF2 Antibody. AbVantage. TM. Pack. Storage:. 2-8ยบ C. Shelf Life: ...
https://www.bethyl.com/product/pdf/A310-291A.pdf...

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KIF2A Antibody
Anti-KIF2A Antibody, Anti-KIF-2A Antibody, Anti-HK2 Antibody, Anti-KIF2. Antibody. KIF2A Antibody. Produced in Rabbit. Storage: ...
http://www.bethyl.com/product/pdf/A300-913A.pdf...

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Anti-Mouse CD90 (Thy 1) (Activating) Low Endotoxin Functional ...
Rat Anti-Mouse CD90 (Clone HK2.1) recognizes the Thy-1.1 and Thy-1.2 alloantigens of ... Functional Assay: Anti-Mouse CD90 (Thy-1) (clone HK2.1) has
been ...
http://www.leinco.com/Antibody/CD90/PC335/HK2.1...

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Cytoskeleton Antibodies
Primary Description: Mouse Anti-Kallikrein 2 (Hk2) Alternative Description : Glandular kallikrein 2 ... ImmuQuest Ltd: View gallery for Kallikrein 2 (Hk2)
...
http://www.immuquest.com/AntibodyCategoriesList.asp?CatID=3...

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