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ACACA


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Symbol:ACACA
Name(s):acetyl-Coenzyme A carboxylase alpha
Type:protein-coding
Organism:Homo sapiens
Synonyms:ACAC, ACC, ACC1, ACCA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18056116 AKR1B10 regulates the stability of acetyl-CoA carboxylase-alpha and is a novel regulator of the biosynthesis of fatty acid, an essential component of the cell membrane, in breast cancer cells
15333468 Observational study of genotype prevalence. (HuGE Navigator)
17372234 Observational study of gene-disease association. (HuGE Navigator)
18031993 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17521700 observations provide complete information about the pattern and levels of LKB1 and p-ACC immunostaining in normal tissues and in lung tumors
17631500 the major mechanism of HER2-mediated induction of FASN and ACCalpha in the breast cancer cells used in this study is translational regulation primarily through the mTOR signaling pathway.
14643797 Transcription of ACC-alpha from at least three promoters and the potential to generate ACC-alpha isozymes with differential susceptibilities to phosphorylation indicate that the regulation of fatty acid synthesis in human tissues is likely to be complex
12810950 Human acetyl-CoA carboxylase 1 gene has three promoters and heterogeneity at the 5'-untranslated mRNA region
17372234 a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer
16326698 BRCA1 affects lipogenesis through binding to P-ACCA, suggesting a new mechanism by which BRCA1 may exert a tumor suppressor function

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDacetyl-Coenzyme A carboxylase alphabreast cancer 1, early onset isoform 1BRCA1 interacts with acetyl-CoA carboxylase.-Pubmed
HPRDacetyl-Coenzyme A carboxylase alpha isoform 1breast cancer 1, early onset isoform 1--Pubmed
HPRDacetyl-Coenzyme A carboxylase alpha isoform 1breast cancer 1, early onset isoform 1--Pubmed

Recent Publications on ACACA:

Pubmed Logo
Hepatic Lipid Composition and Stearoyl-Coenzyme A Desaturase 1 mRNA Expression Can Be Estimated from Plasma VLDL Fatty Acid Ratios.
BACKGROUND: Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting...
24th October, 2009
Department of Internal Medicine, Division of Endocrinology, Diabetology, Clin Chem. 2009 Oct 22.
DOI Direct Link
Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.
Acetyl-coenzyme A carboxylase alpha (ACACA) single-nucleotide polymorphism...
23rd October, 2009
Department of Biostatistics, Kansas University Medical School, Kansas Schizophr Res. 2009 Oct 19.
DOI Direct Link
Polymorphism of the pig acetyl-coenzyme A carboxylase alpha gene is associated with fatty acid composition in a Duroc commercial line.
Acetyl-coenzyme A carboxylase alpha (ACACA) catalyses the first committed...
23rd October, 2009
Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Anim Genet. 2009 Aug;40(4):410-7. Epub 2009 Mar 18.
DOI Direct Link
Adipose tissue lipogenic gene networks due to lipid feeding and milk fat depression in lactating cows.
Dietary lipid supplements have been extensively evaluated for their...
25th August, 2009
Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division J Dairy Sci. 2009 Sep;92(9):4290-300.
DOI Direct Link
Peroxisome proliferator-activated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents.
Several long-chain fatty acids (LCFA) are natural ligands of nonruminant...
25th August, 2009
Department of Animal and Avian Sciences, University of Maryland, College J Dairy Sci. 2009 Sep;92(9):4276-89.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6936697 Secreted and transmembrane polypeptides and nucleic acids encoding the same
7026455 Anti-pro 1343 antibodies
7029875 PRO1343 nucleic acids
7033785 PRO1347 nucleic acids
7033786 Pro1340 nucleic acids

View more patents.

ACACA results (if any) from reagent suppliers

Google CSE Logo
ACCα (T-18) Antibody sc-26817
Human, ACACA, 31, 17q12, NM_198834, NM_198836, NM_198837, NM_198838, NM_198839 · Q13085 · 200350. Mouse, Acaca, 107476, 11 C, Q5SWU9 ...
http://www.scbt.com/datasheet-26817-accalpha-t-18-antibody.h...

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BRCA1 peptide, BRCA1 (Ab-1423) Antibody Blocking Peptide peptide
Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Subunit: Part of the BRCA1-associated genome
...
http://www.genwaybio.com/product_info.php?products_id=213396...

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Abgent - Cell and Function Antibodies
AT1017aNEW, ACAA2 monoclonal antibody (M05), ELISA,WB-Ce,WB-Re, H. AT1018aNEW, ACACA monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

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ACC1/ACC-alpha Bethyl Laboratories
... highly expressed in human breast carcinomas. Alternate names for ACC1/ACC- alpha include acetyl-CoA carboxylase 1, biotin carboxylase, ACACA, ACAC, and
ACCA.
http://www.bethyl.com/category/ACC1_ACC-alpha/Antibody/AAAAA...

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Abgent - Phosphorylation Antibodies - Phosphorylation
AT1014aNEW, ABL2 monoclonal antibody (M09), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H. AT1018aNEW, ACACA monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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ACC Antibody / ACC Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. ACCα (D-5) Antibody, sc-137104, mouse IgG2b, 1-76 (h), WB, IP, IF, ELISA, m, r, h ...
http://www.scbt.com/ko/table-acc.html...

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ACCα (T-18) Antibody sc-26817
Humain, ACACA, 31, 17q12, NM_198834, NM_198836, NM_198837, NM_198838, NM_198839 · Q13085 · 200350. Souris, Acaca, 107476, 11 C, Q5SWU9, Non disponible ...
http://www.scbt.com/fr/datasheet-26817-accalpha-t-18-antibod...

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